A Practical Guide to Rational Drug Design

This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors’ active compounds or from natural ligands of the targets; how to springboard from competitors’ SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. Discusses various tactics applicable to daily drug design Readers can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops Offers a unique viewpoint on drug discovery research due to the author’s cross-discipline education background Explores the author’s rich experiences in both pharmaceutical and academic settings

Produk Detail:

  • Author : Sun Hongmao
  • Publisher : Woodhead Publishing
  • Pages : 292 pages
  • ISBN : 0081001053
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKA Practical Guide to Rational Drug Design

A Practical Guide to Rational Drug Design

A Practical Guide to Rational Drug Design
  • Author : Sun Hongmao
  • Publisher : Woodhead Publishing
  • Release : 05 October 2015
GET THIS BOOKA Practical Guide to Rational Drug Design

This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors’ active compounds or from natural ligands of the targets; how to springboard from competitors’ SAR knowledge in lead

Rational Drug Design

Rational Drug Design
  • Author : American Chemical Society,Abby L. Parrill,M. Rami Reddy,American Chemical Society. Division of Computers in Chemistry
  • Publisher : Amer Chemical Society
  • Release : 17 April 1999
GET THIS BOOKRational Drug Design

This book provides both an overview of current progress in the field of rational drug design and an update on activites related to applied drug design and the development of new methodology for drug design.

A Practical Guide To Cancer Systems Biology

A Practical Guide To Cancer Systems Biology
  • Author : Juan Hsueh-fen,Huang Hsuan-cheng
  • Publisher : World Scientific
  • Release : 29 November 2017
GET THIS BOOKA Practical Guide To Cancer Systems Biology

Systems biology combines computational and experimental approaches to analyze complex biological systems and focuses on understanding functional activities from a systems-wide perspective. It provides an iterative process of experimental measurements, data analysis, and computational simulation to model biological behavior. This book provides explained protocols for high-throughput experiments and computational analysis procedures central to cancer systems biology research and education. Readers will learn how to generate and analyze high-throughput data, therapeutic target protein structure modeling and docking simulation for drug discovery.

A Practical Guide to Scientific Data Analysis

A Practical Guide to Scientific Data Analysis
  • Author : David J. Livingstone
  • Publisher : John Wiley & Sons
  • Release : 10 December 2009
GET THIS BOOKA Practical Guide to Scientific Data Analysis

Inspired by the author's need for practical guidance in the processes of data analysis, A Practical Guide to Scientific Data Analysis has been written as a statistical companion for the working scientist. This handbook of data analysis with worked examples focuses on the application of mathematical and statistical techniques and the interpretation of their results. Covering the most common statistical methods for examining and exploring relationships in data, the text includes extensive examples from a variety of scientific disciplines. The

Computational Chemistry

Computational Chemistry
  • Author : David Young
  • Publisher : John Wiley & Sons
  • Release : 07 April 2004
GET THIS BOOKComputational Chemistry

A practical, easily accessible guide for bench-top chemists, thisbook focuses on accurately applying computational chemistrytechniques to everyday chemistry problems. Provides nonmathematical explanations of advanced topics incomputational chemistry. Focuses on when and how to apply different computationaltechniques. Addresses computational chemistry connections to biochemicalsystems and polymers. Provides a prioritized list of methods for attacking difficultcomputational chemistry problems, and compares advantages anddisadvantages of various approximation techniques. Describes how the choice of methods of software affectsrequirements for computer memory and processing time.

A Practical Guide to Combinatorial Chemistry

A Practical Guide to Combinatorial Chemistry
  • Author : Anthony W. Czarnik,Sheila Hobbs Dewitt
  • Publisher : Amer Chemical Society
  • Release : 17 April 1997
GET THIS BOOKA Practical Guide to Combinatorial Chemistry

Combinatorial chemistry is the ability to simultaneously synthesize vast numbers of diverse compounds. Its techniques have revolutionized the drug discovery process, and are widely used throughout the biotechnology community. Aimed at a wide audience, this text is a down-to-earth introductionto small molecule combinatorial chemistry. It uses a tutorial approach to provide a detailed survey of solid-phase peptide synthesis and solution-phase synthesis. It also reviews current automated approaches and equipment for both solid- and solution-phase library synthesis.

A Practical Guide to Contemporary Pharmacy Practice

A Practical Guide to Contemporary Pharmacy Practice
  • Author : Judith E. Thompson
  • Publisher : Lippincott Williams & Wilkins
  • Release : 17 April 1998
GET THIS BOOKA Practical Guide to Contemporary Pharmacy Practice

combination of prescription processing, compounding, and calculations, this reference helps students see how to apply basic science concepts to practice. Modern techniques and materials for compounding include sample formulations. Sections on calculations show several different methods for solving a given problem

Structure-based Drug Discovery

Structure-based Drug Discovery
  • Author : Harren Jhoti,Andrew R. Leach
  • Publisher : Springer Science & Business Media
  • Release : 24 May 2007
GET THIS BOOKStructure-based Drug Discovery

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.