Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

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  • Author : David T. Curiel
  • Publisher : Academic Press
  • Pages : 868 pages
  • ISBN : 0128005106
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAdenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
  • Author : David T. Curiel
  • Publisher : Academic Press
  • Release : 10 March 2016
GET THIS BOOKAdenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
  • Author : David T. Curiel,Joanne T. Douglas
  • Publisher : Academic Press
  • Release : 15 May 2002
GET THIS BOOKAdenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of

Cancer Gene Therapy

Cancer Gene Therapy
  • Author : David T. Curiel,Joanne T. Douglas
  • Publisher : Springer Science & Business Media
  • Release : 03 November 2007
GET THIS BOOKCancer Gene Therapy

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail

Current Issues in Molecular Virology

Current Issues in Molecular Virology
  • Author : Victor Romanowski
  • Publisher : BoD – Books on Demand
  • Release : 20 November 2013
GET THIS BOOKCurrent Issues in Molecular Virology

This book is a collection of chapters dealing with examples of RNA and DNA viruses, and issues such as how these gene packages have learnt to take advantage of their hosts, molecular recognition events that hosts may use to counterattack the viruses, and how researchers have developed strategies to use viruses or their parts as tools for different purposes.

Therapeutic Applications of Adenoviruses

Therapeutic Applications of Adenoviruses
  • Author : Philip Ng,Nicola Brunetti-Pierri
  • Publisher : CRC Press
  • Release : 12 December 2016
GET THIS BOOKTherapeutic Applications of Adenoviruses

Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
  • Author : Otto-Wilhelm Merten,Mohamed Al-Rubeai
  • Publisher : Springer Science+Business Media
  • Release : 11 April 2021
GET THIS BOOKViral Vectors for Gene Therapy

The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy
  • Author : Roland W. Herzog,Sergei Zolotukhin
  • Publisher : World Scientific
  • Release : 11 April 2021
GET THIS BOOKA Guide to Human Gene Therapy

Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years

Challenges in Delivery of Therapeutic Genomics and Proteomics

Challenges in Delivery of Therapeutic Genomics and Proteomics
  • Author : Ambikanandan Misra
  • Publisher : Elsevier
  • Release : 09 September 2010
GET THIS BOOKChallenges in Delivery of Therapeutic Genomics and Proteomics

Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of

Gene Therapy for Viral Infections

Gene Therapy for Viral Infections
  • Author : Patrick Arbuthnot
  • Publisher : Academic Press
  • Release : 01 June 2015
GET THIS BOOKGene Therapy for Viral Infections

Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene

Gene Therapy

Gene Therapy
  • Author : Mauro Giacca
  • Publisher : Springer Science & Business Media
  • Release : 01 November 2010
GET THIS BOOKGene Therapy

I entered the gene therapy field in the mid-1990s, being fascinated by the immense potential of genes as drugs for the treatment of human disease. Since then, I have experienced the ups and downs of this discipline, and tried to contribute with my work and that of my laboratory to the development of innovative approaches to the treatment of cardiovascular disorders. During these years, I have had several opp- tunities to speak on gene therapy at lectures and academic

Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies

Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies
  • Author : Daniel Scherman
  • Publisher : World Scientific
  • Release : 10 December 2013
GET THIS BOOKAdvanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies

This unique advanced textbook provides a clear and comprehensive description of the field of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of revolutionary gene therapy strategies. In this advanced textbook, more than 25 leading scientists, world-renowned in their respective fields,

Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders

Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders
  • Author : Nicola Brunetti-Pierri
  • Publisher : Springer
  • Release : 22 May 2017
GET THIS BOOKSafety and Efficacy of Gene-Based Therapeutics for Inherited Disorders

In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers,

Advances in Molecular Retrovirology

Advances in Molecular Retrovirology
  • Author : Shailendra K. Saxena
  • Publisher : BoD – Books on Demand
  • Release : 16 March 2016
GET THIS BOOKAdvances in Molecular Retrovirology

This book gives a comprehensive overview of recent advances in Retrovirology, as well as general concepts of molecular biology of retroviral infections, immunopathology, diagnosis, and prevention, to current clinical recommendations in management of retroviruses, including endogenous retroviruses, highlighting the ongoing issues, recent advances, with future directions in diagnostic approaches and therapeutic strategies.

Viral Vectors

Viral Vectors
  • Author : Michael G. Kaplitt,Arthur D. Loewy
  • Publisher : Academic Press
  • Release : 14 August 1995
GET THIS BOOKViral Vectors

Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells. Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for