Oligomerization and Allosteric Modulation in G Protein Coupled Receptors

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments in the field

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  • Author : Anonim
  • Publisher : Academic Press
  • Pages : 488 pages
  • ISBN : 012394791X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKOligomerization and Allosteric Modulation in G Protein Coupled Receptors

Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 02 December 2012
GET THIS BOOKOligomerization and Allosteric Modulation in G-Protein Coupled Receptors

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 13 May 2020
GET THIS BOOKFrom Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction,

Protein Allostery in Drug Discovery

Protein Allostery in Drug Discovery
  • Author : Jian Zhang,Ruth Nussinov
  • Publisher : Springer Nature
  • Release : 09 November 2019
GET THIS BOOKProtein Allostery in Drug Discovery

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent

Allosteric Receptor Modulation in Drug Targeting

Allosteric Receptor Modulation in Drug Targeting
  • Author : Norman G. Bowery
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKAllosteric Receptor Modulation in Drug Targeting

Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing those already working in the field with specific reference information. This title provides in-depth chapters on basic principles of allosterism and its significance at GABAA, 5HT3, nicotinic, and GABAB receptors,

Allosterism in Drug Discovery

Allosterism in Drug Discovery
  • Author : Dario Doller
  • Publisher : Royal Society of Chemistry
  • Release : 24 November 2016
GET THIS BOOKAllosterism in Drug Discovery

Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery. Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is

The Metabotropic Glutamate Receptors

The Metabotropic Glutamate Receptors
  • Author : P. Jeffrey Conn,Jitendra Patel
  • Publisher : Springer Science & Business Media
  • Release : 09 March 2013
GET THIS BOOKThe Metabotropic Glutamate Receptors

The Metabotropic Glutamate Receptors offers state-of-the-art summaries and reviews of virtually everything known today about metabotropic glutamate receptors (mGluRs), including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. Illuminating the overall role played by this crucial class of receptors in brain function, the book also pinpoints those areas in which there is the greatest continuing need for focused research. Because mGluRs have the potential for participating in virtually all known functions of the central nervous system (CNS),

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S.-H. Park
  • Publisher : Academic Press
  • Release : 11 September 2019
GET THIS BOOKGPCRs

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible

Ligand Design for G Protein-coupled Receptors

Ligand Design for G Protein-coupled Receptors
  • Author : Didier Rognan
  • Publisher : John Wiley & Sons
  • Release : 10 March 2006
GET THIS BOOKLigand Design for G Protein-coupled Receptors

1. G protein-coupled receptors in the human genome -- 2. Why G protein-coupled receptors databases are needed -- 3. A novel drug screening assay for G protein-coupled receptors -- 4. Importance of GPCR dimerization for function : the case of the class C GPCRs -- 5. Molecular mechanisms of GPCR activation -- 6. Allosteric properties and regulation of G protein-coupled receptors -- 7. Chemogenomics approaches to ligand design -- 8. Strategies for the design of pGPCR-targeted libraries -- 9. Ligand-based rational design : virtual screening -- 10. 3-D structure of G protein-coupled

Computational Methods for GPCR Drug Discovery

Computational Methods for GPCR Drug Discovery
  • Author : Alexander Heifetz
  • Publisher : Humana Press
  • Release : 30 August 2018
GET THIS BOOKComputational Methods for GPCR Drug Discovery

This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods

Insights into Receptor Function and New Drug Development Targets

Insights into Receptor Function and New Drug Development Targets
  • Author : P. Michael Conn,Claude Kordon
  • Publisher : Springer Science & Business Media
  • Release : 28 September 2006
GET THIS BOOKInsights into Receptor Function and New Drug Development Targets

This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.

Current Antipsychotics

Current Antipsychotics
  • Author : Gerhard Gross,Mark A. Geyer
  • Publisher : Springer Science & Business Media
  • Release : 05 November 2012
GET THIS BOOKCurrent Antipsychotics

Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and

G Protein-Coupled Receptors

G Protein-Coupled Receptors
  • Author : Sandra Siehler,Graeme Milligan
  • Publisher : Cambridge University Press
  • Release : 30 September 2010
GET THIS BOOKG Protein-Coupled Receptors

Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular