Allosteric Modulation of G Protein coupled Receptors

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  • Author : Lauren Therese May
  • Publisher : Anonim
  • Pages : 430 pages
  • ISBN :
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAllosteric Modulation of G Protein coupled Receptors

Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 02 December 2012
GET THIS BOOKOligomerization and Allosteric Modulation in G-Protein Coupled Receptors

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors
  • Author : Christopher J. Langmead
  • Publisher : Academic Press
  • Release : 01 June 2020
GET THIS BOOKFrom Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction,

The Metabotropic Glutamate Receptors

The Metabotropic Glutamate Receptors
  • Author : P. Jeffrey Conn,Jitendra Patel
  • Publisher : Springer Science & Business Media
  • Release : 09 March 2013
GET THIS BOOKThe Metabotropic Glutamate Receptors

The Metabotropic Glutamate Receptors offers state-of-the-art summaries and reviews of virtually everything known today about metabotropic glutamate receptors (mGluRs), including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. Illuminating the overall role played by this crucial class of receptors in brain function, the book also pinpoints those areas in which there is the greatest continuing need for focused research. Because mGluRs have the potential for participating in virtually all known functions of the central nervous system (CNS),

Protein Allostery in Drug Discovery

Protein Allostery in Drug Discovery
  • Author : Jian Zhang,Ruth Nussinov
  • Publisher : Springer Nature
  • Release : 09 November 2019
GET THIS BOOKProtein Allostery in Drug Discovery

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent

Molecular Pharmacology

Molecular Pharmacology
  • Author : Angel Catala,Usama Ahmad
  • Publisher : BoD – Books on Demand
  • Release : 16 December 2020
GET THIS BOOKMolecular Pharmacology

This book concentrates on recent developments related to the application of original structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology as well as basic pharmacological problems that offer mechanistic insights that are generally significant for the field of pharmacology. Written by experts, chapters cover such topics as drug transport mechanisms and drug–receptor complexes. This volume offers up-to-date, expert reviews of the fast-moving field of molecular pharmacology.

Allosteric Receptor Modulation in Drug Targeting

Allosteric Receptor Modulation in Drug Targeting
  • Author : Norman G. Bowery
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKAllosteric Receptor Modulation in Drug Targeting

Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing th

Allosteric Modulation of G Protein-Coupled Receptors

Allosteric Modulation of G Protein-Coupled Receptors
  • Author : Robert B Laprairie
  • Publisher : Academic Press
  • Release : 15 May 2022
GET THIS BOOKAllosteric Modulation of G Protein-Coupled Receptors

Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) allosteric modulation and presents original research in the area, which collectively provides a comprehensive description of the key issues in GPCR allosteric modulation. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signalling at a site apart from the endogenous

Comprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 03 June 2017
GET THIS BOOKComprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches

Pharmacology of G Protein Coupled Receptors

Pharmacology of G Protein Coupled Receptors
  • Author : S. J. Enna
  • Publisher : Academic Press
  • Release : 30 November 2021
GET THIS BOOKPharmacology of G Protein Coupled Receptors

G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological

G-Protein-Coupled Receptor Dimers

G-Protein-Coupled Receptor Dimers
  • Author : Katharine Herrick-Davis,Graeme Milligan,Giuseppe Di Giovanni
  • Publisher : Springer
  • Release : 31 August 2017
GET THIS BOOKG-Protein-Coupled Receptor Dimers

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information