An Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs

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  • Author : Tomas Koltai
  • Publisher : Academic Press
  • Pages : 574 pages
  • ISBN : 0128190604
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Understanding and Treating Cancer: Targeting pH
  • Author : Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey
  • Publisher : Academic Press
  • Release : 16 January 2020
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve

Prostate Cancer Metabolism

Prostate Cancer Metabolism
  • Author : Tomas Koltai,Stephan J. Reshkin,Fátima Baltazar,Larry Fliegel
  • Publisher : Academic Press
  • Release : 15 July 2021
GET THIS BOOKProstate Cancer Metabolism

Prostate Cancer Metabolism: From Biochemistry to Therapeutics summarizes most of the available treatments used in order to target prostate cancer metabolism. Cancer treatments are often evaluated based on survival rates, with little or no emphasis on the patient's quality of life during the survival time. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits.

Molecular Oncology: Underlying Mechanisms and Translational Advancements

Molecular Oncology: Underlying Mechanisms and Translational Advancements
  • Author : Ammad Ahmad Farooqi,Muhammad Ismail
  • Publisher : Springer
  • Release : 29 March 2017
GET THIS BOOKMolecular Oncology: Underlying Mechanisms and Translational Advancements

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity,

Cancer Treatment

Cancer Treatment
  • Author : Letícia Rangel
  • Publisher : BoD – Books on Demand
  • Release : 09 May 2013
GET THIS BOOKCancer Treatment

Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5:

Oxford Textbook of Oncology

Oxford Textbook of Oncology
  • Author : David J. Kerr
  • Publisher : Oxford University Press
  • Release : 17 April 2021
GET THIS BOOKOxford Textbook of Oncology

Written and edited by internationally recognized leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles