An Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs

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  • Author : Tomas Koltai
  • Publisher : Academic Press
  • Pages : 574 pages
  • ISBN : 0128190604
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Understanding and Treating Cancer: Targeting pH
  • Author : Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey
  • Publisher : Academic Press
  • Release : 16 January 2020
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve

Cancer Treatment

Cancer Treatment
  • Author : Letícia Rangel
  • Publisher : BoD – Books on Demand
  • Release : 09 May 2013
GET THIS BOOKCancer Treatment

Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5:

Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery
  • Author : Bhushan Patwardhan,Rathnam Chaguturu
  • Publisher : Academic Press
  • Release : 03 October 2016
GET THIS BOOKInnovative Approaches in Drug Discovery

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches.

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy
  • Author : Andrea Bonetti,Roberto Leone,Franco Muggia,Stephen B. Howell
  • Publisher : Springer Science & Business Media
  • Release : 09 January 2009
GET THIS BOOKPlatinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous

Severe Combined Immunodeficiency: New Insights for the Healthcare Professional: 2011 Edition

Severe Combined Immunodeficiency: New Insights for the Healthcare Professional: 2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 09 January 2012
GET THIS BOOKSevere Combined Immunodeficiency: New Insights for the Healthcare Professional: 2011 Edition

Severe Combined Immunodeficiency: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Severe Combined Immunodeficiency in a compact format. The editors have built Severe Combined Immunodeficiency: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Severe Combined Immunodeficiency in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and

Nano Drug Delivery Strategies for the Treatment of Cancers

Nano Drug Delivery Strategies for the Treatment of Cancers
  • Author : Awesh K. Yadav,Umesh Gupta,Rajeev Sharma
  • Publisher : Academic Press
  • Release : 03 September 2020
GET THIS BOOKNano Drug Delivery Strategies for the Treatment of Cancers

Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and

Treatment of Chronic Pain by Medical Approaches

Treatment of Chronic Pain by Medical Approaches
  • Author : Timothy R. Deer,Michael S. Leong,Vitaly Gordin
  • Publisher : Springer
  • Release : 08 December 2014
GET THIS BOOKTreatment of Chronic Pain by Medical Approaches

From reviews of Deer, eds., Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches: "Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches is a major textbook... [I]t should be a part of all departmental libraries and in the reference collection of pain fellows and pain practitioners. In fact, this text could be to pain as Miller is to general anesthesia." Journal of Neurosurgical Anesthesiology Edited by master clinician-experts appointed by the American Academy of

pH-Interfering Agents as Chemosensitizers in Cancer Therapy

pH-Interfering Agents as Chemosensitizers in Cancer Therapy
  • Author : Claudiu Supuran,Simone Carradori
  • Publisher : Academic Press
  • Release : 15 September 2020
GET THIS BOOKpH-Interfering Agents as Chemosensitizers in Cancer Therapy

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of

Molecular Oncology: Underlying Mechanisms and Translational Advancements

Molecular Oncology: Underlying Mechanisms and Translational Advancements
  • Author : Ammad Ahmad Farooqi,Muhammad Ismail
  • Publisher : Springer
  • Release : 29 March 2017
GET THIS BOOKMolecular Oncology: Underlying Mechanisms and Translational Advancements

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity,

NMR Metabolomics in Cancer Research

NMR Metabolomics in Cancer Research
  • Author : Miroslava Čuperlović-Culf
  • Publisher : Elsevier
  • Release : 17 December 2012
GET THIS BOOKNMR Metabolomics in Cancer Research

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics

Cancer Stem Cells

Cancer Stem Cells
  • Author : Lucie Laplane
  • Publisher : Harvard University Press
  • Release : 06 June 2016
GET THIS BOOKCancer Stem Cells

A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.