Analysis of Complex Disease Association Studies

According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests Extensive list of references including links to tutorial websites Case studies and Tips and Tricks

Produk Detail:

  • Author : Eleftheria Zeggini
  • Publisher : Academic Press
  • Pages : 340 pages
  • ISBN : 9780123751430
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAnalysis of Complex Disease Association Studies

Analysis of Complex Disease Association Studies

Analysis of Complex Disease Association Studies
  • Author : Eleftheria Zeggini,Andrew Morris
  • Publisher : Academic Press
  • Release : 17 November 2010
GET THIS BOOKAnalysis of Complex Disease Association Studies

According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease

Genetic Analysis of Complex Disease

Genetic Analysis of Complex Disease
  • Author : Jonathan L. Haines,Margaret A. Pericak-Vance
  • Publisher : John Wiley & Sons
  • Release : 05 May 2006
GET THIS BOOKGenetic Analysis of Complex Disease

Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease
  • Author : Roger N. Rosenberg
  • Publisher : Lippincott Williams & Wilkins
  • Release : 25 January 2021
GET THIS BOOKThe Molecular and Genetic Basis of Neurologic and Psychiatric Disease

Completely updated for its Fourth Edition, this book is the most comprehensive, current review of the molecular and genetic basis of neurologic and psychiatric diseases. More than 120 leading experts provide a fresh, new assessment of recent molecular, genetic, and genomic advances, offer new insights into disease pathogenesis, describe the newest available therapies, and explore promising areas of therapeutic development. This edition features an updated section on psychiatric disease and expanded, updated chapters on human genomics, gene therapy, and ethical issues.

Rheumatology E-Book

Rheumatology E-Book
  • Author : Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman
  • Publisher : Elsevier Health Sciences
  • Release : 16 June 2014
GET THIS BOOKRheumatology E-Book

Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg’s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell

Genetics of Complex Disease

Genetics of Complex Disease
  • Author : Peter Donaldson,Ann Daly,Luca Ermini,Debra Bevitt
  • Publisher : Garland Science
  • Release : 25 August 2015
GET THIS BOOKGenetics of Complex Disease

Genetics of Complex Disease examines how the identification of genetic variations that increase or reduce the risk of common, genetically complex, diseases can be used to improve our understanding of the pathology of many common diseases; enable better patient management and care; and help with differential diagnosis. It starts with the quest

Handbook of Statistical Genomics

Handbook of Statistical Genomics
  • Author : David J. Balding,Ida Moltke,John Marioni
  • Publisher : John Wiley & Sons
  • Release : 09 July 2019
GET THIS BOOKHandbook of Statistical Genomics

A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies,

Murray and Nadel's Textbook of Respiratory Medicine E-Book

Murray and Nadel's Textbook of Respiratory Medicine E-Book
  • Author : Robert J. Mason,V.Courtney Broaddus,Thomas R Martin,Talmadge E King,Dean Schraufnagel,John F. Murray,Jay A. Nadel
  • Publisher : Elsevier Health Sciences
  • Release : 09 June 2010
GET THIS BOOKMurray and Nadel's Textbook of Respiratory Medicine E-Book

Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease.

Medical Genetics for the Modern Clinician

Medical Genetics for the Modern Clinician
  • Author : Judith A. Westman
  • Publisher : Lippincott Williams & Wilkins
  • Release : 25 January 2021
GET THIS BOOKMedical Genetics for the Modern Clinician

Medical Genetics for the Modern Clinician is a concise, clinically oriented introductory genetics text for medical and allied health students, residents, and clinicians. The book focuses sharply on concepts that are most applicable to clinical practice. Ethics sections in each chapter discuss ethical issues facing today's practitioner, such as counseling, risk assessment, and testing. More than 120 illustrations help students visualize concepts. Each chapter ends with USMLE-style review questions. Appendices include a glossary and a Table of Genes that lists all

Applied Statistical Genetics with R

Applied Statistical Genetics with R
  • Author : Andrea S. Foulkes
  • Publisher : Springer Science & Business Media
  • Release : 28 April 2009
GET THIS BOOKApplied Statistical Genetics with R

Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.

An Introduction to Genetic Epidemiology

An Introduction to Genetic Epidemiology
  • Author : Lyle J. Palmer,George Davey Smith,Paul R. Burton
  • Publisher : Policy Press
  • Release : 31 May 2011
GET THIS BOOKAn Introduction to Genetic Epidemiology

Genetic epidemiology is a field that has acquired a central role in modern biomedical science. This book provides an introduction to genetic epidemiology that begins with a primer in human molecular genetics and then examines the standard methods in population genetics and genetic epidemiology

Genome-wide Association Studies and Genomic Prediction

Genome-wide Association Studies and Genomic Prediction
  • Author : Cedric Gondro,Julius van der Werf,Ben J. Hayes
  • Publisher : Unknown Publisher
  • Release : 25 January 2021
GET THIS BOOKGenome-wide Association Studies and Genomic Prediction

"With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls

An Introduction to Genetic Epidemiology

An Introduction to Genetic Epidemiology
  • Author : Lyle J. Palmer,George Davey Smith,Paul R. Burton
  • Publisher : Policy Press
  • Release : 31 May 2011
GET THIS BOOKAn Introduction to Genetic Epidemiology

Genetic epidemiology is a field that has acquired a central role in modern biomedical science. This book provides an introduction to genetic epidemiology that begins with a primer in human molecular genetics and then examines the standard methods in population genetics and genetic epidemiology

Issues in Life Sciences: Molecular Biology: 2011 Edition

Issues in Life Sciences: Molecular Biology: 2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 09 January 2012
GET THIS BOOKIssues in Life Sciences: Molecular Biology: 2011 Edition

Issues in Life Sciences: Molecular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Molecular Biology. The editors have built Issues in Life Sciences: Molecular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Molecular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences:

Genetics and Genomics of Eye Disease

Genetics and Genomics of Eye Disease
  • Author : Xiaoyi Raymond Gao
  • Publisher : Academic Press
  • Release : 12 September 2019
GET THIS BOOKGenetics and Genomics of Eye Disease

Genetics and Genomics of Eye Disease: Advancing to Precision Medicine thoroughly examines the latest genomics methods for studying eye disease, including complex eye disorders associated with multiple genes. GWAS, WES, WGS, RNA-sequencing, and transcriptome analysis as employed in ocular genomics are discussed in-depth, as are genomics findings tied to early-onset glaucoma, strabismus, age-related macular degeneration, adult-onset glaucoma, diabetic retinopathy, keratoconus, and leber congenital amaurosis, among other diseases. Research and clinical specialists offer guidance on conducting preventative screenings and counseling patients,