Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders

Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.

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  • Author : Robert A. McArthur
  • Publisher : Academic Press
  • Pages : 432 pages
  • ISBN : 0080920403
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAnimal and Translational Models for CNS Drug Discovery Reward Deficit Disorders

Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders

Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders
  • Author : Robert A. McArthur,Franco Borsini
  • Publisher : Academic Press
  • Release : 24 February 2009
GET THIS BOOKAnimal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders

Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic

Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders

Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders
  • Author : Robert A. McArthur,Franco Borsini
  • Publisher : Academic Press
  • Release : 17 November 2008
GET THIS BOOKAnimal and Translational Models for CNS Drug Discovery: Psychiatric Disorders

Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders
  • Author : Robert A. McArthur,Franco Borsini
  • Publisher : Academic Press
  • Release : 20 October 2008
GET THIS BOOKAnimal and Translational Models for CNS Drug Discovery: Neurological Disorders

Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer's disease, Parkinson's disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery

Translational Neuroimaging

Translational Neuroimaging
  • Author : Robert A. McArthur
  • Publisher : Academic Press
  • Release : 11 April 2021
GET THIS BOOKTranslational Neuroimaging

With a unique collaborative approach of author teams from industry and academia, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment provides an integrated perspective of small animal and human brain imaging in the development of translational models and biomarkers to understand human neuropsychiatric disorders and to accelerate the development of novel drugs for their treatment. The book provides chapters on methodical issues in human and animal neuroimaging translational research, allowing a beginning researcher or researcher outside of his/

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release : 15 May 2019
GET THIS BOOKAnimal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery covers recent developments in tumor model systems for translational cancer research. Virtually all types of existing and emerging tumor models in use by the research community are discussed. Areas covered include the latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. Chapters on larger animal models, canine models and their use in pre-IND development make this a unique

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development
  • Author : George G. Nomikos,Douglas E. Feltner
  • Publisher : Academic Press
  • Release : 18 June 2019
GET THIS BOOKTranslational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America
  • Author : Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram
  • Publisher : Frontiers Media SA
  • Release : 21 June 2018
GET THIS BOOKHuman and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders,

Blood-Brain Barrier in Drug Discovery

Blood-Brain Barrier in Drug Discovery
  • Author : Li Di,Edward H. Kerns
  • Publisher : John Wiley & Sons
  • Release : 02 February 2015
GET THIS BOOKBlood-Brain Barrier in Drug Discovery

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design

Animal Models of Cognitive Impairment

Animal Models of Cognitive Impairment
  • Author : Edward D. Levin,Jerry J. Buccafusco
  • Publisher : CRC Press
  • Release : 22 June 2006
GET THIS BOOKAnimal Models of Cognitive Impairment

The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning

Translational Pain Research

Translational Pain Research
  • Author : Lawrence Kruger,Alan R Light
  • Publisher : CRC Press
  • Release : 24 November 2009
GET THIS BOOKTranslational Pain Research

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone

Animal Experimentation

Animal Experimentation
  • Author : Kathrin Herrmann,Kimberley Jayne
  • Publisher : Human-Animal Studies
  • Release : 11 April 2021
GET THIS BOOKAnimal Experimentation

Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

Drug Discovery Toxicology

Drug Discovery Toxicology
  • Author : Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy
  • Publisher : John Wiley & Sons
  • Release : 22 March 2016
GET THIS BOOKDrug Discovery Toxicology

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers

Drug Delivery to the Brain

Drug Delivery to the Brain
  • Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
  • Publisher : Springer Science & Business Media
  • Release : 03 December 2013
GET THIS BOOKDrug Delivery to the Brain

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
  • Author : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
  • Publisher : Academic Press
  • Release : 13 March 2015
GET THIS BOOKThe Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity