Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Produk Detail:

  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Pages : 1108 pages
  • ISBN : 0124159125
  • Rating : 5/5 from 1 reviews
CLICK HERE TO GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders,

Experimental Animal Models of Human Diseases

Experimental Animal Models of Human Diseases
  • Author : Bartholomew Ibeh
  • Publisher : BoD – Books on Demand
  • Release : 23 May 2018
GET THIS BOOKExperimental Animal Models of Human Diseases

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine
  • Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
  • Publisher : National Academies Press
  • Release : 29 May 2018
GET THIS BOOKAdvancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed

Sourcebook of Models for Biomedical Research

Sourcebook of Models for Biomedical Research
  • Author : P. Michael Conn
  • Publisher : Springer Science & Business Media
  • Release : 17 April 2021
GET THIS BOOKSourcebook of Models for Biomedical Research

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Lina Badimon,Laura Casani,Gemma Vilahur
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Experimental approaches to understand the pathophysiology of atherosclerosis and thrombosis involve the combination of both cellular and animal approaches. Animals have been instrumental in biomedical research in order to provide a better understanding on the mechanisms that have already been outlined in in vitro studies. Atherosclerosis studies were firstly carried out in rodents using diet-induced atherosclerosis approaches. However, these diets were un-physiological and the developed lesions were often limited in size, composition, and location largely differing from humans. During the

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Joachim Wistuba,Steffi Werler,Lars Lewejohann
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Klinefelter syndrome (KS) is a frequent (0.2%) sex chromosomal disorder in males presenting with a 47,XXY karyotype. This condition is associated with infertility, hypogonadism, and metabolic and cognitive impairments. As experimental research is restrictive in patients, animal models for KS are needed to explore its molecular and genetic basis. Supernumerary X chromosomes due to meiotic nondisjunctions sporadically also occur in males of other mammalian species and provoke the same or at least some of the features observed in patients. However, as

Cells and Surveys

Cells and Surveys
  • Author : National Research Council,Division of Behavioral and Social Sciences and Education,Committee on Population
  • Publisher : National Academies Press
  • Release : 19 January 2001
GET THIS BOOKCells and Surveys

What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Angela L. Shamchuk,Keith B. Tierney
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Olfactory dysfunction, although caused by many factors including physical damage and genetic abnormalities, is an early stage symptom of several neurodegenerative diseases. Not only is the olfactory system subject to the specific histological abnormalities but patients also lose the capacities to detect, identify, and discriminate among odors. In addition to olfactory deficits, motor dysfunction is another prominent manifestation of these conditions. Recent studies have begun to create zebrafish (Danio rerio) models for neurodegenerative diseases. Despite successful execution, there remains a

Handbook of Models for Human Aging

Handbook of Models for Human Aging
  • Author : P. Michael Conn
  • Publisher : Elsevier
  • Release : 28 April 2011
GET THIS BOOKHandbook of Models for Human Aging

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion

Autoimmune Disease Models

Autoimmune Disease Models
  • Author : Irun R. Cohen,Ariel Miller
  • Publisher : Academic Press
  • Release : 28 June 2014
GET THIS BOOKAutoimmune Disease Models

Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in

Rabbit Biotechnology

Rabbit Biotechnology
  • Author : Louis-Marie Houdebine,Jianglin Fan
  • Publisher : Springer Science & Business Media
  • Release : 24 April 2009
GET THIS BOOKRabbit Biotechnology

Louis-Marie Houdebine and Jianglin Fan The study of biological functions of proteins and their possible roles in the pathogenesis of human diseases requires more and more relevant animal m- els. Although mice including genetically modified mice offer many possibilities, other non-murine species are absolutely required in some circumstances. Rabbit is one of these species, which has been widely used in biomedical studies. This animal is genetically and physiologically closer to humans including cardiov- cular system and metabolism characteristics. Rabbit is

Molecular Pathology of Lung Diseases

Molecular Pathology of Lung Diseases
  • Author : Dani S. Zander,Helmut Popper,Jaishree Jagirdar,Abida Haque,Roberto Barrios
  • Publisher : Springer Science & Business Media
  • Release : 26 May 2010
GET THIS BOOKMolecular Pathology of Lung Diseases

This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Belinda A. Henry,Iain J. Clarke
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Body weight is determined by the balance between energy intake and energy expenditure. Obesity ensues when energy intake exceeds that of energy expenditure. To date, the majority of pharmaco-therapies to control body weight have been directed towards the appetitive limb of this energy balance equation. Very few anti-obesity agents target the manipulation of energy expenditure. The recent unequivocal demonstration that functional brown adipose tissue is present in adult humans has sparked a great deal of interest in developing means to

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Peter Fickert,Marion J. Pollheimer,Christoph H. Österreicher,Michael Trauner
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Cholestatic liver diseases, such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC), represent an important group of liver diseases of the intra- and extrahepatic bile ducts frequently causing end-stage liver disease with significant morbidity and mortality due to limited treatment options. The limitations of the currently available medical therapy largely reflect our deficits in understanding the pathophysiology of cholestatic liver diseases. Therefore, there is an urgent need for reliable, well-defined and easily reproducible animal models to gain insights