Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

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  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Pages : 1108 pages
  • ISBN : 0124159125
  • Rating : 5/5 from 1 reviews
CLICK HERE TO GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders,

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 18 October 2021
GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders,

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 20 June 2017
GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information

Experimental Animal Models of Human Diseases

Experimental Animal Models of Human Diseases
  • Author : Bartholomew Ibeh
  • Publisher : BoD – Books on Demand
  • Release : 23 May 2018
GET THIS BOOKExperimental Animal Models of Human Diseases

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine
  • Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
  • Publisher : National Academies Press
  • Release : 29 May 2018
GET THIS BOOKAdvancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed

Mouse Cell Culture

Mouse Cell Culture
  • Author : Ivan Bertoncello
  • Publisher : Humana Press
  • Release : 20 February 2019
GET THIS BOOKMouse Cell Culture

This volume describes cell culture protocols for the maintenance, propagation, manipulation, and analysis of primary explanted cells from various mouse organ systems. After introductory chapters that examine the applicability of mouse models as a discovery tool and describe critical factors and variables that influence cell culture endpoints, protocol chapters explore cell culture methodologies for specific mouse cell types and lineages. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, comprehensive

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Daniel Butzke,Barbara Grune,Josephine Kugler,Michael Oelgeschläger,Andrea Seiler,Dana Sittner,Manfred Liebsch,Andreas Luch
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

The first years of the 21st century have seen an unparalleled progress in biomedical sciences. Several dogmata that haunted scientific debate for decades were easily abandoned, and there is a fundamental shift away from eminence-based toward evidence-based assessment of preclinical models, probing their true value in predicting clinical outcomes of human diseases. Likewise, several new approaches, e.g., stem cell-based, diseases-in-a-dish and organs-on-a-chip and lab-on-a-chip technologies have revitalized the domain of alternatives to animal experimentation. In our review, we portray

Handbook of Models for Human Aging

Handbook of Models for Human Aging
  • Author : P. Michael Conn
  • Publisher : Elsevier
  • Release : 28 April 2011
GET THIS BOOKHandbook of Models for Human Aging

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Judith Axler Turner
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Identifying and selecting the most appropriate animal model is a challenge, but the U.S. Federal Government’s National Institutes of Health, has supported several efforts to make the job of finding disease models easier. These efforts began with support for databases about specific species, and have graduated to support for discipline-specific studies and cross-species resources. This article tracks LAMHDI, the initiative to Link Animal Models to Human DIsease (www.lamhdi.org), which brings together data about five species: flies,

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Robert H. Miller,Sharyl Fyffe-Maricich,Andrew V. Caprariello
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

The most common demyelinating disease of the central nervous system (CNS) in the young adult population is multiple sclerosis (MS). MS is characterized by the focal loss of myelin sheaths in the brain and in the spinal cord of patients that is correlated with elevated activity of the immune system directed toward CNS antigens including myelin. The progression of MS is highly variable, but in many cases, it is characterized by a series of relapsing and remitting attacks that slowly

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Improving the Utility and Translation of Animal Models for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release : 25 April 2013
GET THIS BOOKImproving the Utility and Translation of Animal Models for Nervous System Disorders

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate

Sourcebook of Models for Biomedical Research

Sourcebook of Models for Biomedical Research
  • Author : P. Michael Conn
  • Publisher : Springer Science & Business Media
  • Release : 07 March 2008
GET THIS BOOKSourcebook of Models for Biomedical Research

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Autoimmune Disease Models

Autoimmune Disease Models
  • Author : Irun R. Cohen,Ariel Miller
  • Publisher : Academic Press
  • Release : 28 June 2014
GET THIS BOOKAutoimmune Disease Models

Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Jerrold Tannenbaum
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying these fundamental principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity

Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents

Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents
  • Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Life Sciences,Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents
  • Publisher : National Academies Press
  • Release : 07 August 2006
GET THIS BOOKOvercoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents

The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents