Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

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  • Author : Asfar Azmi
  • Publisher : Academic Press
  • Pages : 470 pages
  • ISBN : 0128147059
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAnimal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release : 16 April 2019
GET THIS BOOKAnimal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release : 01 December 2010
GET THIS BOOKTumor Models in Cancer Research

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some

Translational Animal Models in Drug Discovery and Development

Translational Animal Models in Drug Discovery and Development
  • Author : Xinkang Wang
  • Publisher : Bentham Science Publishers
  • Release : 03 October 2012
GET THIS BOOKTranslational Animal Models in Drug Discovery and Development

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach
  • Author : Kakoli Bose,Pradip Chaudhari
  • Publisher : Springer Nature
  • Release : 25 November 2019
GET THIS BOOKUnravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of

Mouse Models for Drug Discovery

Mouse Models for Drug Discovery
  • Author : Gabriele Proetzel,Michael V. Wiles
  • Publisher : Humana
  • Release : 23 August 2016
GET THIS BOOKMouse Models for Drug Discovery

As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of

Animal Models for Human Cancer, Volume 69

Animal Models for Human Cancer, Volume 69
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release : 15 August 2016
GET THIS BOOKAnimal Models for Human Cancer, Volume 69

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery
  • Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
  • Publisher : John Wiley & Sons
  • Release : 11 August 2014
GET THIS BOOKIn vivo Models for Drug Discovery

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a

Genetically Engineered Mice for Cancer Research

Genetically Engineered Mice for Cancer Research
  • Author : Jeffrey E. Green,Thomas Ried
  • Publisher : Springer Science & Business Media
  • Release : 08 December 2011
GET THIS BOOKGenetically Engineered Mice for Cancer Research

Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.

Cancer Models

Cancer Models
  • Author : Michael Breitenbach,Jens Hoffmann
  • Publisher : Frontiers Media SA
  • Release : 05 February 2019
GET THIS BOOKCancer Models

Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases.

Alternatives to Animal Testing

Alternatives to Animal Testing
  • Author : Hajime Kojima,Troy Seidle,Horst Spielmann
  • Publisher : Springer
  • Release : 28 January 2019
GET THIS BOOKAlternatives to Animal Testing

This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines,

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research
  • Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum
  • Publisher : National Academies Press
  • Release : 09 January 2016
GET THIS BOOKThe Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in

Drug Discovery and Development

Drug Discovery and Development
  • Author : Omboon Vallisuta,Suleiman Olimat
  • Publisher : BoD – Books on Demand
  • Release : 03 June 2015
GET THIS BOOKDrug Discovery and Development

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against

Anticancer Drug Development Guide

Anticancer Drug Development Guide
  • Author : Beverly A. Teicher,Paul A. Andrews
  • Publisher : Springer Science & Business Media
  • Release : 01 February 2004
GET THIS BOOKAnticancer Drug Development Guide

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules.

Drug Discovery in Pancreatic Cancer

Drug Discovery in Pancreatic Cancer
  • Author : Haiyong Han,Paul Grippo
  • Publisher : Unknown Publisher
  • Release : 23 January 2021
GET THIS BOOKDrug Discovery in Pancreatic Cancer

Over the past two decades, tremendous advances have been made in the field of cancer drug discovery, particularly in the area of molecular and genetic models and technologies, many of which have been or are beginning to be applied to the drug discovery process for pancreatic cancer. Drug Discovery in Pancreatic Cancer: Models and Techniques offers the latest development in the application of those models and technologies in pancreatic cancer. The authors include experts in their perspective field of research

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders,