Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

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  • Author : Asfar Azmi
  • Publisher : Academic Press
  • Pages : 470 pages
  • ISBN : 0128147059
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAnimal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release : 16 April 2019
GET THIS BOOKAnimal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized

Translational Animal Models in Drug Discovery and Development

Translational Animal Models in Drug Discovery and Development
  • Author : Xinkang Wang
  • Publisher : Bentham Science Publishers
  • Release : 03 October 2012
GET THIS BOOKTranslational Animal Models in Drug Discovery and Development

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release : 01 December 2010
GET THIS BOOKTumor Models in Cancer Research

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some

Animal Models for Human Cancer, Volume 69

Animal Models for Human Cancer, Volume 69
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release : 15 August 2016
GET THIS BOOKAnimal Models for Human Cancer, Volume 69

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery
  • Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
  • Publisher : John Wiley & Sons
  • Release : 11 August 2014
GET THIS BOOKIn vivo Models for Drug Discovery

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a

Alternatives to Animal Testing

Alternatives to Animal Testing
  • Author : Hajime Kojima,Troy Seidle,Horst Spielmann
  • Publisher : Springer
  • Release : 27 December 2018
GET THIS BOOKAlternatives to Animal Testing

This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines,

Toxicity Testing in the 21st Century

Toxicity Testing in the 21st Century
  • Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents
  • Publisher : National Academies Press
  • Release : 05 November 2007
GET THIS BOOKToxicity Testing in the 21st Century

Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release : 06 February 2014
GET THIS BOOKImproving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective

Animal Models for Human Cancer

Animal Models for Human Cancer
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger
  • Publisher : John Wiley & Sons
  • Release : 18 May 2016
GET THIS BOOKAnimal Models for Human Cancer

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural

Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy
  • Author : Kenneth K.W. To,William C.S. Cho
  • Publisher : Academic Press
  • Release : 29 July 2020
GET THIS BOOKDrug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Humana Press
  • Release : 02 December 2010
GET THIS BOOKTumor Models in Cancer Research

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some

Clinical Trials in Oncology, Third Edition

Clinical Trials in Oncology, Third Edition
  • Author : Stephanie Green,Jacqueline Benedetti,Angela Smith,John Crowley
  • Publisher : CRC Press
  • Release : 09 May 2012
GET THIS BOOKClinical Trials in Oncology, Third Edition

The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review of methods and issues related to cancer clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. In addition, the book has been restructured to have separate chapters and expanded discussions on general clinical trials issues, and issues specific to Phases I, II, and III. New sections cover innovations

Phenotypic Drug Discovery

Phenotypic Drug Discovery
  • Author : Beverley Isherwood,Angelique Augustin
  • Publisher : Royal Society of Chemistry
  • Release : 10 December 2020
GET THIS BOOKPhenotypic Drug Discovery

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and

Drug Discovery and Development

Drug Discovery and Development
  • Author : Omboon Vallisuta,Suleiman Olimat
  • Publisher : BoD – Books on Demand
  • Release : 03 June 2015
GET THIS BOOKDrug Discovery and Development

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research
  • Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum
  • Publisher : National Academies Press
  • Release : 09 January 2016
GET THIS BOOKThe Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in