Annotating New Genes

In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cover programming guidelines, including a specific case study on the use of C-It for in silico screening. The second half of the book offers a step-by-step guide to experimental validation concepts and procedures, as well as an overview of additional potential applications of this approach in the field of stem cells and tissue regeneration, before a concluding chapter summarises the concepts and theories presented. Focuses not only on screening but also on biological validations Provides details of databases and software (web interface) products for biologists with minimal computation skills Offers a step-by-step outline of the procedure involved

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  • Author : Shizuka Uchida
  • Publisher : Elsevier
  • Pages : 196 pages
  • ISBN : 1908818123
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAnnotating New Genes

Annotating New Genes

Annotating New Genes
  • Author : Shizuka Uchida
  • Publisher : Elsevier
  • Release : 06 August 2012
GET THIS BOOKAnnotating New Genes

In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases

Gene Prediction

Gene Prediction
  • Author : Martin Kollmar
  • Publisher : Humana Press
  • Release : 19 May 2019
GET THIS BOOKGene Prediction

This volume introduces software used for gene prediction with focus on eukaryotic genomes. The chapters in this book describe software and web server usage as applied in common use-cases, and explain ways to simplify re-annotation of long available genome assemblies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary computational requirements, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough,

Sequence — Evolution — Function

Sequence — Evolution — Function
  • Author : Eugene Koonin,Michael Y. Galperin
  • Publisher : Springer Science & Business Media
  • Release : 30 November 2002
GET THIS BOOKSequence — Evolution — Function

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the

Bioinformatics and Functional Genomics

Bioinformatics and Functional Genomics
  • Author : Jonathan Pevsner
  • Publisher : Wiley-Liss
  • Release : 04 November 2003
GET THIS BOOKBioinformatics and Functional Genomics

Analyzing DNA, RNA, and protein sequences in databases -- Access to sequence data and literature -- Pairwise sequence alignment -- Basic Local Alignment Search Tool (BLAST) -- Advanced BLAST searching -- Genomewide analysis of RNA and protein -- Bioinformatic approaches to gene expression -- Gene expression: microarray data analysis -- Protein analysis and proteomics -- Protein structure -- Multiple sequence alignment -- Molecular phylogeny and evolution -- Completed genomes and the tree of life -- Completed genomes: viruses -- Completed

The Gene Ontology Handbook

The Gene Ontology Handbook
  • Author : Christophe Dessimoz,Nives Škunca
  • Publisher : Humana Press
  • Release : 26 November 2016
GET THIS BOOKThe Gene Ontology Handbook

This book is open access under a CC BY 4.0 license. This book provides a practical and self-contained overview of the Gene Ontology (GO), the leading project to organize biological knowledge on genes and their products across genomic resources. Written for biologists and bioinformaticians, it covers the state-of-the-art of how GO annotations are made, how they are evaluated, and what sort of analyses can and cannot be done with the GO. In the spirit of the Methods in Molecular Biology book

Assessing Rare Variation in Complex Traits

Assessing Rare Variation in Complex Traits
  • Author : Eleftheria Zeggini,Andrew Morris
  • Publisher : Springer
  • Release : 13 August 2015
GET THIS BOOKAssessing Rare Variation in Complex Traits

This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. Chapters provide details of state-of-the-art methodology for rare variant detection and calling, imputation and analysis in samples of unrelated individuals and families. The book also covers analytical issues associated with the study of

The Grape Genome

The Grape Genome
  • Author : Dario Cantu,M. Andrew Walker
  • Publisher : Springer Nature
  • Release : 13 November 2019
GET THIS BOOKThe Grape Genome

This book describes the current state of international grape genomics, with a focus on the latest findings, tools and strategies employed in genome sequencing and analysis, and genetic mapping of important agronomic traits. It also discusses how these are having a direct impact on outcomes for grape breeders and the international grape research community. While V. vinifera is a model species, it is not always appreciated that its cultivation usually requires the use of other Vitis species as rootstocks. The

The Tomato Genome

The Tomato Genome
  • Author : Mathilde Causse,Jim Giovannoni,Mondher Bouzayen,Mohamed Zouine
  • Publisher : Springer
  • Release : 21 November 2016
GET THIS BOOKThe Tomato Genome

This book describes the strategy used for sequencing, assembling and annotating the tomato genome and presents the main characteristics of this sequence with a special focus on repeated sequences and the ancestral polyploidy events. It also includes the chloroplast and mitochondrial genomes. Tomato (Solanum lycopersicum) is a major crop plant as well as a model for fruit development, and the availability of the genome sequence has completely changed the paradigm of the species’ genetics and genomics. The book describes the

The Sports Gene

The Sports Gene
  • Author : David Epstein
  • Publisher : Penguin
  • Release : 01 August 2013
GET THIS BOOKThe Sports Gene

The New York Times bestseller – with a new afterword about early specialization in youth sports – by the author of Range: Why Generalists Triumph in a Specialized World. The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training? In this controversial and engaging exploration

Modern Genome Annotation

Modern Genome Annotation
  • Author : D. Frishman,Alfonso Valencia
  • Publisher : Springer Science & Business Media
  • Release : 02 October 2009
GET THIS BOOKModern Genome Annotation

An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale

Bioinformatics

Bioinformatics
  • Author : Jonathan M. Keith
  • Publisher : Humana
  • Release : 21 June 2018
GET THIS BOOKBioinformatics

This second edition provides updated and expanded chapters covering a broad sampling of useful and current methods in the rapidly developing and expanding field of bioinformatics. Bioinformatics, Volume I: Data, Sequence Analysis, and Evolution, Second Edition is comprised of three sections: Data and Databases, Sequence Analysis, and Phylogenetics and Evolution. The first section details bioinformatics methodologies in the generation of sequence and structural data and its organization into conceptual categories, and databases to facilitate further analyses. The Sequence Analysis section

Computational Genomics with R

Computational Genomics with R
  • Author : Altuna Akalin
  • Publisher : Chapman & Hall/CRC Computational Biology Series
  • Release : 26 November 2020
GET THIS BOOKComputational Genomics with R

Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the

Bioinformatics

Bioinformatics
  • Author : Christine Orengo,David Jones,Janet Thornton
  • Publisher : Taylor & Francis
  • Release : 16 December 2003
GET THIS BOOKBioinformatics

Bioinformatics, the use of computers to address biological questions, has become an essential tool in biological research. It is one of the critical keys needed to unlock the information encoded in the flood of data generated by genome, protein structure, transcriptome and proteome research. Bioinformatics: Genes, Proteins & Computers covers both the more traditional approaches to bioinformatics, including gene and protein sequence analysis and structure prediction, and more recent technologies such as datamining of transcriptomic and proteomic data to provide insights

Genetics, Genomics, and Breeding of Grapes

Genetics, Genomics, and Breeding of Grapes
  • Author : Anne-Francoise Adam-Blondon,Jose-Miguel Martinez-Zapater,Chittaranjan Kole
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKGenetics, Genomics, and Breeding of Grapes

Grapevine is a highly valuable crop worldwide, both from a cultural as well as a commercial point of view. One of its major advantages is that it is well adapted to scarce water conditions. The main object of grapevine breeding is to develop varieties that are resistant to pathogens and at the same time well-adapted to a changing environment. Since the beginning of the 21st century, there has been a concerted effort by the international scientific community to develop genomic

The Kiwifruit Genome

The Kiwifruit Genome
  • Author : Raffaele Testolin,Hong-Wen Huang,Allan Ross Ferguson
  • Publisher : Springer
  • Release : 02 May 2016
GET THIS BOOKThe Kiwifruit Genome

This book describes the basic botanical features of kiwifruit and its wild relatives, reports on the steps that led to its genome sequencing, and discusses the results obtained with the assembly and annotation. The core chapters provide essential insights into the main gene families that characterize this species as a crop, including the genes controlling sugar and starch metabolism, pigment biosynthesis and degradation, the ascorbic-acid pathway, fruit softening and postharvest metabolism, allergens, and resistance to pests and diseases. The book