Annotating New Genes

In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cover programming guidelines, including a specific case study on the use of C-It for in silico screening. The second half of the book offers a step-by-step guide to experimental validation concepts and procedures, as well as an overview of additional potential applications of this approach in the field of stem cells and tissue regeneration, before a concluding chapter summarises the concepts and theories presented. Focuses not only on screening but also on biological validations Provides details of databases and software (web interface) products for biologists with minimal computation skills Offers a step-by-step outline of the procedure involved

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  • Author : Shizuka Uchida
  • Publisher : Elsevier
  • Pages : 196 pages
  • ISBN : 1908818123
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAnnotating New Genes

Annotating New Genes

Annotating New Genes
  • Author : Shizuka Uchida
  • Publisher : Elsevier
  • Release : 06 August 2012
GET THIS BOOKAnnotating New Genes

In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases

Genome Annotation

Genome Annotation
  • Author : Jung Soh,Paul M.K. Gordon,Christoph W. Sensen
  • Publisher : CRC Press
  • Release : 30 August 2012
GET THIS BOOKGenome Annotation

The success of individualized medicine, advanced crops, and new and sustainable energy sources requires thoroughly annotated genomic information and the integration of this information into a coherent model. A thorough overview of this field, Genome Annotation explores automated genome analysis and annotation from its origins to the challenges of next-generation sequencing data analysis. The book initially takes you through the last 16 years since the sequencing of the first complete microbial genome. It explains how current analysis strategies were developed, including

Development of New Tools and Pipelines for Plant Bioinformatics Applications

Development of New Tools and Pipelines for Plant Bioinformatics Applications
  • Author : Omar M. Darwish
  • Publisher : Unknown Publisher
  • Release : 28 November 2021
GET THIS BOOKDevelopment of New Tools and Pipelines for Plant Bioinformatics Applications

Blueberry is an economically and nutritionally important small fruit crop, native to North America. As with many crops, extreme low temperature can affect blueberry crop yield negatively and cause major losses to growers. For this reason, blueberry breeding programs have focused on developing improved cultivars with broader climatic adaptation. To help achieve this goal, the blueberry genomic database (BBGD454) was developed to provide the research community with valuable resources to identify genes that play an important role in flower bud

Next Generation Sequencing

Next Generation Sequencing
  • Author : Jerzy Kulski
  • Publisher : BoD – Books on Demand
  • Release : 14 January 2016
GET THIS BOOKNext Generation Sequencing

Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and

Sequence — Evolution — Function

Sequence — Evolution — Function
  • Author : Eugene V. Koonin,Michael Galperin
  • Publisher : Springer Science & Business Media
  • Release : 29 June 2013
GET THIS BOOKSequence — Evolution — Function

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the

Bioinformatics and Functional Genomics

Bioinformatics and Functional Genomics
  • Author : Jonathan Pevsner
  • Publisher : John Wiley & Sons
  • Release : 04 March 2005
GET THIS BOOKBioinformatics and Functional Genomics

Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key

Gene Prediction

Gene Prediction
  • Author : Martin Kollmar
  • Publisher : Humana Press
  • Release : 19 May 2019
GET THIS BOOKGene Prediction

This volume introduces software used for gene prediction with focus on eukaryotic genomes. The chapters in this book describe software and web server usage as applied in common use-cases, and explain ways to simplify re-annotation of long available genome assemblies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary computational requirements, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough,

An Integrated Approach to Enhancing Functional Annotation of Sequences for Data Analysis of a Transcriptome

An Integrated Approach to Enhancing Functional Annotation of Sequences for Data Analysis of a Transcriptome
  • Author : Matthew Morritt Hindle
  • Publisher : Unknown Publisher
  • Release : 28 November 2021
GET THIS BOOKAn Integrated Approach to Enhancing Functional Annotation of Sequences for Data Analysis of a Transcriptome

Given the ever increasing quantity of sequence data, functional annotation of new gene sequences persists as being a significant challenge for bioinformatics. This is a particular problem for transcriptomics studies in crop plants where large genomes and evolutionarily distant model organisms, means that identifying the function of a given gene used on a microarray, is often a non-trivial task. Information pertinent to gene annotations is spread across technically and semantically heterogeneous biological databases. Combining and exploiting these data in a

The Gene Ontology Handbook

The Gene Ontology Handbook
  • Author : Christophe Dessimoz,Nives Skunca
  • Publisher : Unknown Publisher
  • Release : 08 October 2020
GET THIS BOOKThe Gene Ontology Handbook

This book provides a practical and self-contained overview of the Gene Ontology (GO), the leading project to organize biological knowledge on genes and their products across genomic resources. Written for biologists and bioinformaticians, it covers the state-of-the-art of how GO annotations are made, how they are evaluated, and what sort of analyses can and cannot be done with the GO. In the spirit of the Methods in Molecular Biology book series, there is an emphasis throughout the chapters on providing

IMG ER

IMG ER
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 28 November 2021
GET THIS BOOKIMG ER

A rapidly increasing number of microbial genomes are sequenced by organizations worldwide and are eventually included into various public genome data resources. The quality of the annotations depends largely on the original dataset providers, with erroneous or incomplete annotations often carried over into the public resources and difficult to correct. We have developed an Expert Review (ER) version of the Integrated Microbial Genomes (IMG) system, with the goal of supporting systematic and efficient revision of microbial genome annotations. IMG ER

Computational Genomics with R

Computational Genomics with R
  • Author : Altuna Akalin
  • Publisher : CRC Press
  • Release : 16 December 2020
GET THIS BOOKComputational Genomics with R

Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the

Modern Genome Annotation

Modern Genome Annotation
  • Author : D. Frishman,Alfonso Valencia
  • Publisher : Springer Science & Business Media
  • Release : 02 October 2009
GET THIS BOOKModern Genome Annotation

An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale

The Peanut Genome

The Peanut Genome
  • Author : Rajeev K. Varshney,Manish K. Pandey,Naveen Puppala
  • Publisher : Springer
  • Release : 16 December 2017
GET THIS BOOKThe Peanut Genome

This book presents the current state of the art in peanut genomics, focusing particularly on the latest genomic findings, tools and strategies employed in genome sequencing, transcriptomes and analysis, availability of public and private genomic resources, and ways to maximize the use of this information in peanut breeding programs. Further, it demonstrates how advances in plant genomics can be used to improve crop breeding. The peanut or groundnut (Arachis hypogaea L. Millsp) is a globally important grain legume and oilseed

The Tomato Genome

The Tomato Genome
  • Author : Mathilde Causse,Jim Giovannoni,Mondher Bouzayen,Mohamed Zouine
  • Publisher : Springer
  • Release : 21 November 2016
GET THIS BOOKThe Tomato Genome

This book describes the strategy used for sequencing, assembling and annotating the tomato genome and presents the main characteristics of this sequence with a special focus on repeated sequences and the ancestral polyploidy events. It also includes the chloroplast and mitochondrial genomes. Tomato (Solanum lycopersicum) is a major crop plant as well as a model for fruit development, and the availability of the genome sequence has completely changed the paradigm of the species’ genetics and genomics. The book describes the

Modern Biocatalysis

Modern Biocatalysis
  • Author : Gavin Williams,Mélanie Hall
  • Publisher : Royal Society of Chemistry
  • Release : 31 May 2018
GET THIS BOOKModern Biocatalysis

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics