Antimalarial Agents

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work towards antimalarial solution, providing practical guidance on current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a focus on biological aspects of malaria, this book highlights the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. The book also includes detailed study of the medicinal chemistry of antimalarial agents and a focus on the design of antimalarial drugs. Drawing on the knowledge of its expert authors and coupling historic research with current findings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs, including academic researchers, medicinal chemists, malaria researchers and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected

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  • Author : Graham L. Patrick
  • Publisher : Elsevier
  • Pages : 622 pages
  • ISBN : 0081012411
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAntimalarial Agents

Antimalarial Agents

Antimalarial Agents
  • Author : Graham L. Patrick
  • Publisher : Elsevier
  • Release : 30 May 2020
GET THIS BOOKAntimalarial Agents

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work towards antimalarial solution, providing practical guidance on current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs

Hepatotoxicity

Hepatotoxicity
  • Author : Hyman J. Zimmerman
  • Publisher : Lippincott Williams & Wilkins
  • Release : 20 October 1999
GET THIS BOOKHepatotoxicity

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an

Saving Lives, Buying Time

Saving Lives, Buying Time
  • Author : Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
  • Publisher : National Academies Press
  • Release : 09 October 2004
GET THIS BOOKSaving Lives, Buying Time

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called “artemisinins†are available, they are unaffordable for the majority of the affected population, even at a

Antimalarial Agents

Antimalarial Agents
  • Author : Poul Thompson
  • Publisher : Elsevier
  • Release : 02 December 2012
GET THIS BOOKAntimalarial Agents

Medicinal Chemistry, Volume 12: Antimalarial Agents: Chemistry and Pharmacology presents the essentials of both biology and chemistry pertinent to the chemotherapy of malaria. This book discusses the nature of the disease, the physiology and biochemistry of the plasmodia, and the mode of action of drugs. Organized into 19 chapters, this volume begins with an overview of the most intensive efforts to develop synthetic antimalarial drugs. This text then examines how drugs are evaluated as well as the specific chemotherapy in malaria. Other

Malaria Control During Mass Population Movements and Natural Disasters

Malaria Control During Mass Population Movements and Natural Disasters
  • Author : Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University,National Research Council,Committee on Population,Roundtable on the Demography of Forced Migration,Holly A. Williams,Peter B. Bloland
  • Publisher : National Academies Press
  • Release : 16 January 2003
GET THIS BOOKMalaria Control During Mass Population Movements and Natural Disasters

Admittedly, the world and the nature of forced migration have changed a great deal over the last two decades. The relevance of data accumulated during that time period can now be called into question. The roundtable and the Program on Forced Migration at the Mailman School of Public Health of Columbia University have commissioned a series of epidemiological reviews on priority public health problems for forced migrants that will update the state of knowledge. Malaria Control During Mass Population Movements

Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice
  • Publisher : National Academies Press
  • Release : 24 March 2020
GET THIS BOOKAssessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts

Guidelines for the Treatment of Malaria

Guidelines for the Treatment of Malaria
  • Author : World Health Organization
  • Publisher : World Health Organization
  • Release : 20 October 2021
GET THIS BOOKGuidelines for the Treatment of Malaria

"The purpose of this document is to provide comprehensible, global, evidence-based guidelines to help formulate policies and protocols for the treatment of malaria. Information is presented on the treatment of uncomplicated malaria, including disease in special groups (young children, pregnant women, people who are HIV positive, travellers from non-malaria endemic regions) and in complex emergency situations and severe malaria."--Publisher's description.

Antimalarial Chemotherapy

Antimalarial Chemotherapy
  • Author : Philip J. Rosenthal
  • Publisher : Springer Science & Business Media
  • Release : 01 April 2001
GET THIS BOOKAntimalarial Chemotherapy

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy:

Treatment and Prevention of Malaria

Treatment and Prevention of Malaria
  • Author : Henry M. Staines,Sanjeev Krishna
  • Publisher : Springer Science & Business Media
  • Release : 05 January 2012
GET THIS BOOKTreatment and Prevention of Malaria

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the

Antimalarial Agents: Advances in Research and Application: 2011 Edition

Antimalarial Agents: Advances in Research and Application: 2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 09 January 2012
GET THIS BOOKAntimalarial Agents: Advances in Research and Application: 2011 Edition

Antimalarial Agents: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Antimalarial Agents in a compact format. The editors have built Antimalarial Agents: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antimalarial Agents in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antimalarial Agents:

CDC Yellow Book 2018: Health Information for International Travel

CDC Yellow Book 2018: Health Information for International Travel
  • Author : Centers for Disease Control and Prevention CDC
  • Publisher : Oxford University Press
  • Release : 17 April 2017
GET THIS BOOKCDC Yellow Book 2018: Health Information for International Travel

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the

Antimalarial Drug II

Antimalarial Drug II
  • Author : Anonim
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKAntimalarial Drug II

The construction of this volume has been guided by two personal convictions. Experience in the field of experimental chemotherapy, both in the pharmaceutical industry and academia, has convinced us that recent quantum technological advances in biochemistry, molecular biology, and immunology will permit and, indeed, necessitate an increasingly greater use of rational drug development in the future than has been the custom up to now. In Part l, therefore, we asked our contributors to provide detailed reviews covering the biology of

Synthesis of New Antimalarial Agents

Synthesis of New Antimalarial Agents
  • Author : F. I. Carroll,John A. Kepler,RESEARCH TRIANGLE INST RESEARCH TRIANGLE PARK NC.
  • Publisher : Unknown Publisher
  • Release : 20 October 1986
GET THIS BOOKSynthesis of New Antimalarial Agents

This study is concerned with the preparation of: a) peroxides based on qinghaosu, b) peptide pro-drug derivatives of primaquine, and c) thymidylate synthetase inhibitors as potentially new antimalarial agents. During this study, thirty (30) target compounds were prepared and submitted for antimalarial evaluation. The thirty compounds included twenty-four (24) qinghaosu analogs, three (3) primaquine derivative and three (3) thymidylate synthetase inhibitors. Twenty-one of the qinghaosu analogs and all three of the thymidylate synthetase inhibitors were evaluated in the malaria in vitro drug screen. All

Malaria

Malaria
  • Author : Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control
  • Publisher : National Academies Press
  • Release : 01 February 1991
GET THIS BOOKMalaria

Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the