Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

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  • Author : Allan Matte
  • Publisher : Elsevier
  • Pages : 222 pages
  • ISBN : 0081030193
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKApproaches to the Purification Analysis and Characterization of Antibody Based Therapeutics

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics
  • Author : Allan Matte
  • Publisher : Elsevier
  • Release : 07 September 2020
GET THIS BOOKApproaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in

Analytical Characterization of Biotherapeutics

Analytical Characterization of Biotherapeutics
  • Author : Jennie R. Lill,Wendy Sandoval
  • Publisher : John Wiley & Sons
  • Release : 14 August 2017
GET THIS BOOKAnalytical Characterization of Biotherapeutics

The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting

Therapeutic Fc-Fusion Proteins

Therapeutic Fc-Fusion Proteins
  • Author : Steven M. Chamow,Thomas Ryll,Henry B. Lowman,Deborah Farson
  • Publisher : John Wiley & Sons
  • Release : 18 December 2013
GET THIS BOOKTherapeutic Fc-Fusion Proteins

Edited by three pioneers in the field, each with longstanding experience in the biotech industry, and a skilled scientific writer, this is the first book to cover every step in the development and production of immunoglobulin Fc-fusion proteins as therapeutics for human disease: from choosing the right molecular design, to pre-clinical characterization of the purified product, through to batch optimization and quality control for large-scale cGMP production. The whole of the second part is devoted to case studies of Fc-fusion

Analysis of Aggregates and Particles in Protein Pharmaceuticals

Analysis of Aggregates and Particles in Protein Pharmaceuticals
  • Author : Hanns-Christian Mahler,Wim Jiskoot
  • Publisher : John Wiley & Sons
  • Release : 20 December 2011
GET THIS BOOKAnalysis of Aggregates and Particles in Protein Pharmaceuticals

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.

Process Scale Purification of Antibodies

Process Scale Purification of Antibodies
  • Author : Uwe Gottschalk
  • Publisher : John Wiley & Sons
  • Release : 03 April 2017
GET THIS BOOKProcess Scale Purification of Antibodies

Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes

Immunological Approaches to the Diagnosis and Therapy of Breast Cancer

Immunological Approaches to the Diagnosis and Therapy of Breast Cancer
  • Author : G.P. Talwar
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKImmunological Approaches to the Diagnosis and Therapy of Breast Cancer

Once again we have gathered to discover and evaluate advances made in our ability to understand. diagnose and possibly treat breast cancer with the new reagents provided by monoclonal antibody techniques. In the last two years since our first International Workshop on Monoclonal Antibodies and Breast Cancer there has been an enormous surge in the number and quality of applications for these new reagents. Solid achievements have been made in identification and quantitation of estrogen and progesterone receptors. in histopathological

Antibody Production

Antibody Production
  • Author : L. E. Glynn,M. W. Steward
  • Publisher : Wiley
  • Release : 26 February 1981
GET THIS BOOKAntibody Production

A practical guide to the production of antibodies. Describes the biosynthesis of antibody molecules by B lymphocytes and their progeny, the use of genetic markers in the elucidation of mechanisms of antibody synthesis, and of the generation of antibody diversity. Also deals with anomalies in antibody production which result in immunoglobulinopathies, involving qualitative or quantitative abnormalities, or both, in the immunoglobulins.

Monoclonal Antibody Production

Monoclonal Antibody Production
  • Author : National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies
  • Publisher : National Academies Press
  • Release : 06 June 1999
GET THIS BOOKMonoclonal Antibody Production

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The

Antibody Engineering

Antibody Engineering
  • Author : Thomas Böldicke
  • Publisher : BoD – Books on Demand
  • Release : 21 February 2018
GET THIS BOOKAntibody Engineering

Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by

Therapeutic Proteins

Therapeutic Proteins
  • Author : Vladimir Voynov,Justin A. Caravella
  • Publisher : Humana Press
  • Release : 01 May 2016
GET THIS BOOKTherapeutic Proteins

Emphasizing the newest developments in the field, this volume presents detailed methodswith added emphasison therapeutic protein discovery. It features key tips and valuable implementation advice to ensure successful results."

Making and Using Antibodies

Making and Using Antibodies
  • Author : Gary C. Howard,Matthew R. Kaser
  • Publisher : CRC Press
  • Release : 13 December 2006
GET THIS BOOKMaking and Using Antibodies

Antibodies are an indispensable tool in the study of biology and medicine. Making and Using Antibodies: A Practical Handbook presents techniques in a single, comprehensive source for the production and use of antibodies. It enables researchers to immediately access lab-tested, proven protocols. Written and edited by an elite team of scienti

Application of Liquid Chromatography-mass Spectrometry-based Protein and Proteomic Analytical Approaches to Chinese Hamster Ovary Cell Based Industrial Biopharmaceutical Production

Application of Liquid Chromatography-mass Spectrometry-based Protein and Proteomic Analytical Approaches to Chinese Hamster Ovary Cell Based Industrial Biopharmaceutical Production
  • Author : Yuanwei Gao
  • Publisher : Unknown Publisher
  • Release : 30 November 2021
GET THIS BOOKApplication of Liquid Chromatography-mass Spectrometry-based Protein and Proteomic Analytical Approaches to Chinese Hamster Ovary Cell Based Industrial Biopharmaceutical Production

Therapeutic proteins have emerged rapidly over the past several decades, providing effective and innovative medicines for a wide range of previously refractory human diseases. Chinese hamster ovary (CHO) cells have become the predominant choice as the cellular expression system for such therapeutic production in the biopharmaceutical industry. The high throughput of the protein drug production depends on both the efficient upstream process yielding high product titers and proficient downstream purification with high product recovery and effective impurity removal. Numerous efforts

Principles and Reactions of Protein Extraction, Purification, and Characterization

Principles and Reactions of Protein Extraction, Purification, and Characterization
  • Author : Hafiz Ahmed,Hafiz Ahmed PhD
  • Publisher : CRC Press
  • Release : 27 July 2017
GET THIS BOOKPrinciples and Reactions of Protein Extraction, Purification, and Characterization

Principles and Reactions of Protein Extraction, Purification, and Characterization provides the mechanisms and experimental procedures for classic to cutting-edge techniques used in protein extraction, purification, and characterization. The author presents the principles and reactions behind each procedure and uses tables to compare the different