Astrocytes and Epilepsy

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Produk Detail:

  • Author : Jacqueline A. Hubbard
  • Publisher : Academic Press
  • Pages : 394 pages
  • ISBN : 0128026243
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAstrocytes and Epilepsy

Astrocytes and Epilepsy

Astrocytes and Epilepsy
  • Author : Jacqueline A. Hubbard,Devin K. Binder
  • Publisher : Academic Press
  • Release : 05 July 2016
GET THIS BOOKAstrocytes and Epilepsy

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of

Crucial Role for Astrocytes in Epilepsy

Crucial Role for Astrocytes in Epilepsy
  • Author : Peter Bedner,Christian Steinhäuser
  • Publisher : Biota Publishing
  • Release : 01 August 2015
GET THIS BOOKCrucial Role for Astrocytes in Epilepsy

This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies that prevent generation of the disorder and improve seizure control in individuals already afflicted. The vast majority of epileptic cases are of idiopathic origin with their underlying mechanisms being unclear.

Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies
  • Author : Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta
  • Publisher : Oxford University Press
  • Release : 01 June 2012
GET THIS BOOKJasper's Basic Mechanisms of the Epilepsies

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these

The Causes of Epilepsy

The Causes of Epilepsy
  • Author : Simon D. Shorvon,Frederick Andermann,Renzo Guerrini
  • Publisher : Cambridge University Press
  • Release : 14 April 2011
GET THIS BOOKThe Causes of Epilepsy

Causation is an aspect of epilepsy neglected in the scientific literature and in the conceptualization of epilepsy at a clinical and experimental level. It was to remedy this deficiency that this book was conceived. The book opens with a draft etiological classification that goes some way to filling the nosological void. The book is divided into four etiological categories: idiopathic, symptomatic, cryptogenic, and provoked epilepsies. Each chapter considers topics in a consistent fashion, dealing with the phenomenon of epilepsy in

Astrocytes

Astrocytes
  • Author : Eliana Scemes,David C. Spray
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKAstrocytes

Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellular connections and surveys the most current findings on astrocyte activity. The first section of the book identifies major astrocyte biomarkers and describes how they define the different connectivity

Epilepsy

Epilepsy
  • Author : Associate Professor of Neurology Neuroscience and Molecular & Human Genetics Jeffrey L Noebels
  • Publisher : Unknown Publisher
  • Release : 01 November 2015
GET THIS BOOKEpilepsy

"Epilepsy affects millions worldwide and represents a variety of disorders characterized by seizures. This book examines the neurobiological bases of these conditions and current research into treatment strategies"--

Seizures and Epilepsy

Seizures and Epilepsy
  • Author : Jerome Engel
  • Publisher : Oxford University Press
  • Release : 31 January 2013
GET THIS BOOKSeizures and Epilepsy

This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.

Inflammation and Epilepsy: New Vistas

Inflammation and Epilepsy: New Vistas
  • Author : Damir Janigro,Astrid Nehlig,Nicola Marchi
  • Publisher : Springer Nature
  • Release : 18 May 2021
GET THIS BOOKInflammation and Epilepsy: New Vistas

This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute

Glial Amino Acid Transporters

Glial Amino Acid Transporters
  • Author : Arturo Ortega,Arne Schousboe
  • Publisher : Springer
  • Release : 21 August 2017
GET THIS BOOKGlial Amino Acid Transporters

This ambitious compendium provides an extensive overview on the "supporting cells" of the vertebrate central nervous system, these being glial cells which far outnumber neurons but are much less understood. Covering multiple aspects of this family of transporters-- from structural properties, to their involvement in signaling and gene expression regulation, this volume presents the most recent research on the roles of glial amino acid transporters as key molecules of brain metabolism and signaling.

The Glutamate/GABA-Glutamine Cycle

The Glutamate/GABA-Glutamine Cycle
  • Author : Arne Schousboe,Ursula Sonnewald
  • Publisher : Springer
  • Release : 25 November 2016
GET THIS BOOKThe Glutamate/GABA-Glutamine Cycle

Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion