Astrocytes and Epilepsy

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Produk Detail:

  • Author : Jacqueline A. Hubbard
  • Publisher : Academic Press
  • Pages : 394 pages
  • ISBN : 0128026243
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKAstrocytes and Epilepsy

Astrocytes and Epilepsy

Astrocytes and Epilepsy
  • Author : Jacqueline A. Hubbard,Devin K. Binder
  • Publisher : Academic Press
  • Release : 05 July 2016
GET THIS BOOKAstrocytes and Epilepsy

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of

Crucial Role for Astrocytes in Epilepsy

Crucial Role for Astrocytes in Epilepsy
  • Author : Peter Bedner,Christian Steinhäuser
  • Publisher : Biota Publishing
  • Release : 01 August 2015
GET THIS BOOKCrucial Role for Astrocytes in Epilepsy

This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies that prevent generation of the disorder and improve seizure control in individuals already afflicted. The vast majority of epileptic cases are of idiopathic origin with their underlying mechanisms being unclear.

Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies
  • Author : Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta
  • Publisher : Oxford University Press
  • Release : 01 June 2012
GET THIS BOOKJasper's Basic Mechanisms of the Epilepsies

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these

Astrocytes

Astrocytes
  • Author : Eliana Scemes,David C. Spray
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKAstrocytes

Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellular connections and surveys the most current findings on astrocyte activity. The first section of the book identifies major astrocyte biomarkers and describes how they define the different connectivity

Astrocytes in (Patho)Physiology of the Nervous System

Astrocytes in (Patho)Physiology of the Nervous System
  • Author : Vladimir Parpura,Philip G. Haydon
  • Publisher : Springer Science & Business Media
  • Release : 11 December 2008
GET THIS BOOKAstrocytes in (Patho)Physiology of the Nervous System

Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into

The Causes of Epilepsy

The Causes of Epilepsy
  • Author : Simon D. Shorvon,Frederick Andermann,Renzo Guerrini
  • Publisher : Cambridge University Press
  • Release : 14 April 2011
GET THIS BOOKThe Causes of Epilepsy

Causation is an aspect of epilepsy neglected in the scientific literature and in the conceptualization of epilepsy at a clinical and experimental level. It was to remedy this deficiency that this book was conceived. The book opens with a draft etiological classification that goes some way to filling the nosological void. The book is divided into four etiological categories: idiopathic, symptomatic, cryptogenic, and provoked epilepsies. Each chapter considers topics in a consistent fashion, dealing with the phenomenon of epilepsy in

Homeostatic Control of Brain Function

Homeostatic Control of Brain Function
  • Author : Detlev Boison,Susan A. Masino
  • Publisher : Oxford University Press
  • Release : 01 December 2015
GET THIS BOOKHomeostatic Control of Brain Function

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies

Febrile Seizures

Febrile Seizures
  • Author : Tallie Z. Baram,Shlomo Shinnar
  • Publisher : Academic Press
  • Release : 07 May 2021
GET THIS BOOKFebrile Seizures

Febrile Seizures is written by the most active researchers and clinicians in epilepsy research today. This book presents the latest developments in this field as well as the current state of knowledge in the following: New imaging tools and emerging data, visualizing effects of febrile seizures on the brain; New genetic methodologies; The use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure. First book on febrile seizures in over 20 years! Broad spectrum

Understanding Epilepsy

Understanding Epilepsy
  • Author : Vibhangini S. Wasade,Marianna V. Spanaki
  • Publisher : Cambridge University Press
  • Release : 21 November 2019
GET THIS BOOKUnderstanding Epilepsy

A comprehensive, accessible synthesis of current information on epilepsy for medical trainees and physicians preparing for board certification.

Epilepsy

Epilepsy
  • Author : Associate Professor of Neurology Neuroscience and Molecular & Human Genetics Jeffrey L Noebels
  • Publisher : Unknown Publisher
  • Release : 01 November 2015
GET THIS BOOKEpilepsy

"Epilepsy affects millions worldwide and represents a variety of disorders characterized by seizures. This book examines the neurobiological bases of these conditions and current research into treatment strategies"--

Neuroglia

Neuroglia
  • Author : Helmut Kettenmann,Bruce R. Ransom
  • Publisher : Oxford University Press
  • Release : 07 May 2021
GET THIS BOOKNeuroglia

Graduate students in neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology will find the book indispensable. It is also a vital companion for researchers in these fields as well as clinicians in neurology, neurosurgery, neuropathology, neuro-oncology, physiatry, and psychiatry."--BOOK JACKET.