Basics of Chimeric Antigen Receptor CAR Immunotherapy

Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field. Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols Provides unique authority as the editor has worked directly with CARs Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field

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  • Author : Mumtaz Y. Balkhi
  • Publisher : Academic Press
  • Pages : 92 pages
  • ISBN : 0128197471
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBasics of Chimeric Antigen Receptor CAR Immunotherapy

Basics of Chimeric Antigen Receptor (CAR) Immunotherapy

Basics of Chimeric Antigen Receptor (CAR) Immunotherapy
  • Author : Mumtaz Y. Balkhi
  • Publisher : Academic Press
  • Release : 31 July 2019
GET THIS BOOKBasics of Chimeric Antigen Receptor (CAR) Immunotherapy

Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application

Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book

Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book
  • Author : Daniel W. Lee,Nirali N. Shah
  • Publisher : Elsevier Health Sciences
  • Release : 30 November 2019
GET THIS BOOKChimeric Antigen Receptor T-Cell Therapies for Cancer E-Book

From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging

Chimeric Antigen Receptor T Cells

Chimeric Antigen Receptor T Cells
  • Author : Kamilla Swiech,Kelen Cristina Ribeiro Malmegrim,Virgínia Picanço-Castro
  • Publisher : Humana
  • Release : 24 November 2020
GET THIS BOOKChimeric Antigen Receptor T Cells

This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and

Stem Cells – From Hype to Real Hope

Stem Cells – From Hype to Real Hope
  • Author : Khawaja Husnain Haider,Salim Aziz, MD
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 17 December 2018
GET THIS BOOKStem Cells – From Hype to Real Hope

This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells:

Immunotherapy

Immunotherapy
  • Author : Krassimir Metodiev
  • Publisher : BoD – Books on Demand
  • Release : 26 April 2017
GET THIS BOOKImmunotherapy

This is another attempt of InTechOpen to continue the dissemination of international knowledge and experience in the field of immunology. The present book includes a number of modern concepts of specialists and experts in the field of immunotherapy, covering the major topics and analyzing the history, current stage, and future ideas of application of modern immunomodulation. It is always a benefit, but also a compliment, to gather a team of internationally distinguished authors and to motivate them to reveal their

Developments in T Cell Based Cancer Immunotherapies

Developments in T Cell Based Cancer Immunotherapies
  • Author : Paolo A. Ascierto,David F. Stroncek,Ena Wang
  • Publisher : Humana Press
  • Release : 26 November 2015
GET THIS BOOKDevelopments in T Cell Based Cancer Immunotherapies

This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when

Cancer Immunology and Immunotherapy

Cancer Immunology and Immunotherapy
  • Author : Mansoor M. Amiji,Lara Scheherazade Milane
  • Publisher : Academic Press
  • Release : 18 August 2021
GET THIS BOOKCancer Immunology and Immunotherapy

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of

Tumor Microenvironment

Tumor Microenvironment
  • Author : Peter P. Lee,Francesco M. Marincola
  • Publisher : Springer Nature
  • Release : 25 March 2020
GET THIS BOOKTumor Microenvironment

This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for

Cancer Immunotherapy Principles and Practice

Cancer Immunotherapy Principles and Practice
  • Author : Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
  • Publisher : Springer Publishing Company
  • Release : 28 June 2017
GET THIS BOOKCancer Immunotherapy Principles and Practice

Cancer Immunotherapy Principles and Practice, from the Society of Immunotherapy of Cancer (SITC), is the authoritative reference on cancer immunobiology and the immunotherapy treatments that harness the immune system to combat malignant disease. Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy

Global Epidemiology of Cancer

Global Epidemiology of Cancer
  • Author : Jahangir Moini,Nicholas G. Avgeropoulos,Craig Badolato
  • Publisher : John Wiley & Sons
  • Release : 28 March 2022
GET THIS BOOKGlobal Epidemiology of Cancer

GLOBAL EPIDEMIOLOGY OF CANCER Cancer is the second highest cause of death in the United States, and a leading cause of death globally. Our goals are to discuss the global epidemiology of various cancers, with detailed information on their prevalence, incidence, and clinical considerations. Epidemiology is the key to understanding the mortality and morbidity of cancer, and how we can prevent, diagnose, and treat the disease. Prevention of cancer is essential for saving lives. Prevalence and incidence of cancer are

Introduction to Antibody Engineering

Introduction to Antibody Engineering
  • Author : Florian Rüker,Gordana Wozniak-Knopp
  • Publisher : Springer Nature
  • Release : 04 January 2021
GET THIS BOOKIntroduction to Antibody Engineering

This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering”

Immunotherapy of Hepatocellular Carcinoma

Immunotherapy of Hepatocellular Carcinoma
  • Author : Tim F. Greten
  • Publisher : Springer
  • Release : 04 October 2017
GET THIS BOOKImmunotherapy of Hepatocellular Carcinoma

In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of

Cancer Cell Signaling

Cancer Cell Signaling
  • Author : Martha Robles-Flores
  • Publisher : Humana
  • Release : 12 November 2020
GET THIS BOOKCancer Cell Signaling

This fully updated edition provides the most recent advances in cancer cell signaling knowledge combined with some discussion of the current challenges and prospects in cancer therapy. Beginning with an important section on cancer resistance, the main obstacle to effective cancer therapy, the book continues with chapters exploring state-of-the-art methods in epigenetic control of cancer, metastasis promotion, as well as a variety of new technologies in the study of cancer. Written for the highly successful Methods in Molecular Biology series,

The Basics of Cancer Immunotherapy

The Basics of Cancer Immunotherapy
  • Author : Haidong Dong,Svetomir N. Markovic
  • Publisher : Springer
  • Release : 05 January 2018
GET THIS BOOKThe Basics of Cancer Immunotherapy

This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize