Between the Lines of Genetic Code

Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care. Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases. Systematically integrates methods of defining and detecting gene interactions to provide an overview of the field Critically analyzes current methods and tools to aid researchers in integrating gene interaction studies Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future

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  • Author : Leonid Padyukov
  • Publisher : Academic Press
  • Pages : 232 pages
  • ISBN : 0123973023
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBetween the Lines of Genetic Code

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Leonid Padyukov
  • Publisher : Academic Press
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Klementy Shchetynsky,Leonid Padyukov
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

Functional analysis of genetic variants in association with human complex diseases remains a challenge for modern research. Discovery of gene–gene interactions may represent an additional tool for identifying specific polymorphisms involved in disease development. It not only identifies new candidate genes for mechanistic studies, but also suggests biological relations in the function of these genes with certain variants in developing disease. We describe a few examples of the studies where a link between statistical evidence of gene–gene interaction

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Jesper Tegnér,Francesco Marabita,David Gomez-Cabrero
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

Following the success of genome-wide association studies, it is now important to unravel interactions between genes as well as between genes and environment. Here we discuss how to interpret higher order statistical interactions in terms of underlying biological processes purportedly generating such dependencies. In this chapter, we specifically review how biological networks, such as those generated from systems biological approaches, could possibly facilitate the interpretation of observed interactions in the development of complex phenotypes, e.g., complex diseases. We conclude

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Robert G Cooper,Hector Chinoy,Ingrid E. Lundberg
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

The idiopathic inflammatory myopathies (IIMs) represent a complex spectrum of overlapping connective tissue diseases which have skeletal muscle involvement as one of their major components. While recent immunogenetic research has shown that myositis-specific and myositis-associated autoantibodies (MSAs/MAAs) are clearly associated with and thus define many clinical IIM subsets, future research is needed to clarify whether these antibodies (Abs) are just a secondary epiphenomenon, i.e., representing surrogate markers for underlying human leukocyte antigen (HLA) genes and or genotypes, or

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Leonid Padyukov,Lars Alfredsson
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

Rheumatoid arthritis (RA) is a chronic autoimmune disease with poorly understood etiology. Over the years, many genetic risk factors and some environmental risk factors were discovered to be important for RA. Genetic variants from the HLA-DRB1 locus, the shared epitope alleles, in different populations show a relatively strong and consistent effect on risk of RA. Non-HLA genetic risk factors have only a moderate effect. Gene–gene and gene–environment interactions were suspected to be important with regard to the risk

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Marylyn D. Ritchie
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

Gene–gene interactions are a critical component of the genetic architecture of complex, human traits. Unfortunately, the detection and characterization of interactions is a challenge. This is due to a number of factors including the combinatorial explosion of possible interactions in large-scale genomic data, limited power in small sample sizes, and potential difficulty interpreting or validating the resulting interaction models. A number of data mining methods have been developed to deal with one or more of these challenges. In this

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Bo Ding
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

Genome-wide interaction studies is an extremely challenging problem in statistics, in which conventional methods are often inadequate in terms of both power and computational efficiency. An exhaustive search for genome-wide gene–gene interactions becomes feasible with modern cluster computing run on graphics processing units. However, the large number of tests accompanying the search raises a serious multiple testing problem. A way to overcome these limits is to apply a filtering step prior to the combinatorial method and to analyze only

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Ingrid Kockum,Lars Alfredsson,Tomas Olsson
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

Multiple sclerosis (MS) is a multifactorial disease where both environmental and genetic risk factors play a role. More than 50 genetic polymorphisms have been identified in association with MS mostly by mapping close to genes involved in immunoregulation. Several environmental factors have been associated with risk for developing MS, including smoking, obesity, EBV infections, and lack of sun exposure. Interactions between major genetic risk factors and environmental exposures have been observed making it possible to begin to form groups of risk

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Igor Sandalov,Leonid Padyukov
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

We introduce new quantitative characteristics of the population using an analogy to the system of multi-spin molecules: the disease fields, which may depend on interactions, and the susceptibility to disease as derivative of genetic vector’s (GV’s) frequency of cases with respect to these fields. The genetic vector’s approach (GVA) is applied to statistical analysis of the interaction of two SNP haplotype of HTR2A and shared epitope (SE) alleles in relation to development of rheumatoid arthritis (RA).

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Camilla Bengtsson,Henrik Källberg
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

Many diseases are believed to occur as a result of interactions between genes and environment. In epidemiology, there are several study designs, such as cohort and case-control studies, that can be used to analyze biological interaction. In this chapter, we discuss crucial issues in the design stage of epidemiologic studies, how different measures of disease occurrence and measures of associations are calculated, and how systematic and random errors might hamper the accuracy of the results. By properly addressing these issues,

Between the Lines of Genetic Code

Between the Lines of Genetic Code
  • Author : Henrik Källberg,Camilla Bengtsson
  • Publisher : Elsevier Inc. Chapters
  • Release : 28 September 2013
GET THIS BOOKBetween the Lines of Genetic Code

This chapter deals with estimation of interaction through different statistical models. Interaction is classified into two different classes, antagonistic and synergistic effects. An antagonistic effect is said to be present if the combination of two factors decrease the measure of interest as compared to the expected sum of the single effect of each factor. Synergistic effect is present if the combination of two factors increases the measure of interest more than the expected sum based on each factor. Furthermore, this

Mapping and Sequencing the Human Genome

Mapping and Sequencing the Human Genome
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
  • Publisher : National Academies Press
  • Release : 01 January 1988
GET THIS BOOKMapping and Sequencing the Human Genome

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a

The Genetics of Cancer

The Genetics of Cancer
  • Author : B.A. Ponder,M.J. Waring
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKThe Genetics of Cancer

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development.