Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Produk Detail:

  • Author : Brian J Arey
  • Publisher : Elsevier
  • Pages : 316 pages
  • ISBN : 0124115071
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBiased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics
  • Author : Brian J Arey
  • Publisher : Elsevier
  • Release : 05 June 2014
GET THIS BOOKBiased Signaling in Physiology, Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S.-H. Park
  • Publisher : Academic Press
  • Release : 11 September 2019
GET THIS BOOKGPCRs

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible

Calving Management and Newborn Calf Care

Calving Management and Newborn Calf Care
  • Author : João Simões,George Stilwell
  • Publisher : Springer Nature
  • Release : 28 August 2021
GET THIS BOOKCalving Management and Newborn Calf Care

This comprehensive textbook provides detailed information on calving management in dairy and beef cattle. Enriched with diverse learning opportunities, it conveys the fundamentals of reproductive anatomy and physiology, parturition, birth complications and various obstetrical manoeuvres, as well as dam and calf care. In order to promote best practices in this specialized subject, the book covers all significant points from conception to calving and the perinatal period. Clear chapter structures, a wealth of illustrations and videos, obstetrical case studies, and question-and-answer

New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications

New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications
  • Author : Marc J.M. Abadie,Mariana Pinteala,Alexandru Rotaru
  • Publisher : Springer Nature
  • Release : 26 May 2021
GET THIS BOOKNew Trends in Macromolecular and Supramolecular Chemistry for Biological Applications

This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations.The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to

Pharmacology of G Protein Coupled Receptors

Pharmacology of G Protein Coupled Receptors
  • Author : S. J. Enna
  • Publisher : Academic Press
  • Release : 15 August 2022
GET THIS BOOKPharmacology of G Protein Coupled Receptors

G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological

Pharmacology and Therapeutics of Constitutively Active Receptors

Pharmacology and Therapeutics of Constitutively Active Receptors
  • Author : Ya-Xiong Tao
  • Publisher : Elsevier
  • Release : 11 June 2014
GET THIS BOOKPharmacology and Therapeutics of Constitutively Active Receptors

Volume 70 of Advances in Pharmacology presents the pharmacology and therapeutics of constitutively active receptors. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Advances in Pharmacology provides a rich collection of reviews on timely topics. The series places emphasis on the molecular bases of drug action, both applied and experimental. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and

GPCR Signaling in Cancer

GPCR Signaling in Cancer
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 20 February 2020
GET THIS BOOKGPCR Signaling in Cancer

GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in

Melatonin

Melatonin
  • Author : Cristina Manuela Drăgoi,Alina Crenguţa Nicolae
  • Publisher : BoD – Books on Demand
  • Release : 21 November 2018
GET THIS BOOKMelatonin

Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal

Pain Therapeutics

Pain Therapeutics
  • Author : Charlotte Allerton
  • Publisher : Royal Society of Chemistry
  • Release : 04 November 2013
GET THIS BOOKPain Therapeutics

This book presents a contemporary review of the field of Pain Therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others. Additional discussion highlights the current challenges of

Good Research Practice in Non-Clinical Pharmacology and Biomedicine

Good Research Practice in Non-Clinical Pharmacology and Biomedicine
  • Author : Anton Bespalov,Martin C. Michel,Thomas Steckler
  • Publisher : Springer Nature
  • Release : 01 January 2020
GET THIS BOOKGood Research Practice in Non-Clinical Pharmacology and Biomedicine

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Origins of Sound Change

Origins of Sound Change
  • Author : Alan C. L. Yu
  • Publisher : Oxford University Press
  • Release : 10 January 2013
GET THIS BOOKOrigins of Sound Change

This volume showcases the current state of the art in phonologization research, bringing together work by leading scholars in sound change research from different disciplinary and scholarly traditions.

The Molecular Biology of Arrestins

The Molecular Biology of Arrestins
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 10 June 2013
GET THIS BOOKThe Molecular Biology of Arrestins

This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field. Contributions from leading authorities Informs and updates on all the latest developments in the field

Serotonin

Serotonin
  • Author : Fatima Shad Kaneez
  • Publisher : BoD – Books on Demand
  • Release : 26 July 2017
GET THIS BOOKSerotonin

Serotonin - A Chemical Messenger Between All Types of Living Cells is a very interesting book on the most ancient neurotransmitter, hormone and trophic factor serotonin or 5-hydroxytryptamine (5-HT). This unique chemical is present in all living cells including plants and animals. This book will take us through a serene journey of the evolutionary history of serotonin and its role from man to mollusk. There are many interesting chapters incorporated in this book, including novel approaches for detecting minor metabolites

Principles and Practice of Clinical Trial Medicine

Principles and Practice of Clinical Trial Medicine
  • Author : Richard Chin,Bruce Y Lee
  • Publisher : Elsevier
  • Release : 25 July 2008
GET THIS BOOKPrinciples and Practice of Clinical Trial Medicine

Clinical trials are an important part of medicine and healthcare today, deciding which treatments we use to treat patients. Anyone involved in healthcare today must know the basics of running and interpreting clinical trial data. Written in an easy-to-understand style by authors who have considerable expertise and experience in both academia and industry, Principles and Practice of Clinical Trial Medicine covers all of the basics of clinical trials, from legal and ethical issues to statistics, to patient recruitment and reporting