Biochemistry of Collagens Laminins and Elastin

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides an updated comprehensive introduction to collagen and structural proteins Gives insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes seven new chapters, including one on how collagen biomarkers are used in clinical research to support drug development and in precision medicine Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function, and durability

Produk Detail:

  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Pages : 434 pages
  • ISBN : 0128170697
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBiochemistry of Collagens Laminins and Elastin

Biochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins and Elastin
  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Release : 28 May 2019
GET THIS BOOKBiochemistry of Collagens, Laminins and Elastin

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally

Biochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins and Elastin
  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Release : 15 August 2016
GET THIS BOOKBiochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes

Collagen

Collagen
  • Author : Marcel E. Nimni
  • Publisher : CRC Press
  • Release : 18 January 2018
GET THIS BOOKCollagen

This series was conceived with the idea of integrating current aspects of ongoing research in the collagen field. The book consists of a spectrum of papers which discus divers aspects such as X-ray structure, the thermodynamics and mechanism of fibrillogenesis, and the use of collagen as a biomaterial for the manufacturing of many implantable, sometimes lifesaving, devises.

The Extracellular Matrix Factsbook

The Extracellular Matrix Factsbook
  • Author : Shirley Ayad,Ray Boot-Handford,Martin Humphries,Karl Kadler,Adrian Shuttleworth
  • Publisher : Elsevier
  • Release : 27 March 1998
GET THIS BOOKThe Extracellular Matrix Factsbook

The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references. Key Features * Compiled by members of one of the foremost centers of matrix biochemistry in the world * Contains over 30 new entries, with all previous entries

Progress in Heritable Soft Connective Tissue Diseases

Progress in Heritable Soft Connective Tissue Diseases
  • Author : Jaroslava Halper
  • Publisher : Springer Science & Business Media
  • Release : 18 January 2014
GET THIS BOOKProgress in Heritable Soft Connective Tissue Diseases

This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and

The Extracellular Matrix: an Overview

The Extracellular Matrix: an Overview
  • Author : Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release : 16 February 2011
GET THIS BOOKThe Extracellular Matrix: an Overview

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept

Methods in Extracellular Matrix Biology

Methods in Extracellular Matrix Biology
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 05 January 2018
GET THIS BOOKMethods in Extracellular Matrix Biology

Methods in Extra Cellular Matrix, Volume 142, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections devoted to Elastin, Quantification of collagen and elastin, Fibrillins, Lysyl oxidase, Fibulins, Matrilins, Hyaluronic Acid, Small leucine-rich proteoglycans, Syndecans, Fibronectin, SPARC, Thrombospondins, Tenascins, Collagen IV, Multi-photon analysis of ECM, Cell-derived extracellular matrices, Laminins, Fibrillar Collagens, Imaging ECM in developing embryos, Analysis

Cell Biology of Extracellular Matrix

Cell Biology of Extracellular Matrix
  • Author : E.D. Hay
  • Publisher : Springer Science & Business Media
  • Release : 11 November 2013
GET THIS BOOKCell Biology of Extracellular Matrix

In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For

Composition and Function of the Extracellular Matrix in the Human Body

Composition and Function of the Extracellular Matrix in the Human Body
  • Author : Francesco Travascio
  • Publisher : BoD – Books on Demand
  • Release : 15 June 2016
GET THIS BOOKComposition and Function of the Extracellular Matrix in the Human Body

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book

Muscle and Meat Biochemistry

Muscle and Meat Biochemistry
  • Author : A.M. Pearson
  • Publisher : Elsevier
  • Release : 02 December 2012
GET THIS BOOKMuscle and Meat Biochemistry

Muscle and Meat Biochemistry teaches the different concepts and topics under the eponymous subject. The book covers the gross and detailed composition and structure of muscles and the relationship of the nervous system with the muscular system; muscle cell differentiation and growth; proteins of the thick filament; and the molecular structure and enzymatic activity of myosin. The text also discusses the proteins found in the thin filament - actin, troponin, and myosin; skeletal muscle growth; protein metabolism; and fiber types.

Extracellular Matrix Degradation

Extracellular Matrix Degradation
  • Author : William C. Parks,Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release : 07 April 2011
GET THIS BOOKExtracellular Matrix Degradation

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases,

Carbohydrate Chemistry: Chemical and Biological Approaches Volume 44

Carbohydrate Chemistry: Chemical and Biological Approaches Volume 44
  • Author : Amelia Pilar Rauter,Thisbe K Lindhorst,Yves Queneau
  • Publisher : Royal Society of Chemistry
  • Release : 06 October 2020
GET THIS BOOKCarbohydrate Chemistry: Chemical and Biological Approaches Volume 44

This invaluable volume contains analysed, evaluated and distilled information on the latest in carbohydrate research.The discovery and synthesis of novel carbohydrates and mimetics with diverse applications continues to be a major challenge for carbohydrate chemists. The understanding of the structure and function of carbohydrates and glycoconjugates remains vital in medicine and molecular biology. Covering both chemical and biological science related to the particular volume topic, this series demonstrates the interdisciplinary nature of modern carbohydrate research, and benefits any researcher