Biological DNA Sensor

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

Produk Detail:

  • Author : Ken J. Ishii
  • Publisher : Academic Press
  • Pages : 352 pages
  • ISBN : 9780124047327
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBiological DNA Sensor

Biological DNA Sensor

Biological DNA Sensor
  • Author : Ken J. Ishii,Choon Kit Tang
  • Publisher : Academic Press
  • Release : 07 November 2013
GET THIS BOOKBiological DNA Sensor

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete

Biological DNA Sensor

Biological DNA Sensor
  • Author : Choon Kit Tang,Cevayir Coban,Shizuo Akira,Ken J. Ishii
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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In this chapter, we reflect on our early understanding of the immunogenic properties of dsDNA and give a chronological account of the journey we have taken to discover the individual cellular DNA sensors which have played important roles in mediating DNA induced inflammation.

Biological DNA Sensor

Biological DNA Sensor
  • Author : Y.J. Shen,A.R. Lam,S.W.S. Ho,C.X. Koo,N. Le Bert,S. Gasser
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Toll-like receptors, NOD-like receptors and numerous intracellular sensors that detect nucleotides in the cytosol help to initiate immune responses to viral infections. Many of the cytosolic nucleotide sensors and their downstream mediators also play a role in RNA metabolism, DNA repair and cancer. Here we review the evidence that links cytosolic DNA sensors to processes that are activated in cancer cells.

Biological DNA Sensor

Biological DNA Sensor
  • Author : Surya Pandey,Taro Kawai
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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DNA sensors initiate innate immune responses upon recognition of microbial and self-derived DNA in the intracellular compartments or cytoplasm. These sensors include TLR9, AIM2 like receptors and many other recently identified cytosolic DNA sensors. The otherwise protective nature of host defense by these receptors can turn hostile when they recognize self-DNA through various mechanisms and aberrantly activate DNA sensing pathways leading to unregulated or inappropriate type I IFN production and consequent autoimmune and autoinflammatory diseases. In this chapter, we highlight

Biological DNA Sensor

Biological DNA Sensor
  • Author : Søren R. Paludan,Andrew G. Bowie
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Microbial and host DNA are potent stimulators of innate immune responses and have been implicated in both host defense and autoimmune diseases. To date more than 10 immunological sensors of DNA have been proposed, and we are now beginning to understand the functions and mechanism of action of these proposed DNA sensors in host defense and diseases. Much of the current knowledge on DNA sensing has been obtained through studies with herpesviruses. Hence, in this chapter, we review and critically assess

Biological DNA Sensor

Biological DNA Sensor
  • Author : Glen N. Barber
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Invading microbes are detected by cellular sensors, the consequences of which result in the production of potent anti-pathogen proteins such as type I interferon (IFN) as well as other cytokines capable of stimulating the adaptive immune response. Examples comprise the RIG-I-like helicase (RLH) and the Toll-like receptor (TLR) families which recognize non-self-pathogen derived molecules (PAMPs) including bacterial lipopolysaccharides as well as nucleic acids. In addition, an endoplasmic reticulum (ER) associated transmembrane protein referred to as STING (for stimulator of interferon

Biological DNA Sensor

Biological DNA Sensor
  • Author : Sivapriya Kailasan Vanaja,Vijay A.K. Rathinam,Katherine A. Fitzgerald
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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The innate immune response serves as the first line of defense against microbial infections by detecting pathogen-associated molecular patterns through germline-encoded pattern recognition receptors. Proteins of the PYHIN family have gained substantial research focus in recent years as central mediators of innate immune responses induced by cytosolic microbial DNA. Sensing of DNA by PYHINs typically leads to activation of inflammasomes and/or type I interferon responses that are crucial for host defense against invading pathogens. Certain members of the family

Biological DNA Sensor

Biological DNA Sensor
  • Author : Christophe J. Desmet
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Aluminum-based adjuvants (alum) are among the oldest and most widely used vaccine adjuvants. After decades of largely empirical use, the last years have witnessed a flurry of studies aiming to decipher the immunological mechanisms of action of alum. Along with other hypotheses, recent reports support that alum induces the release by host cells of their own DNA at sites of injection. Extracellular self-DNA would in turn activate the innate immune system through known and yet to be identified innate immune

Biological DNA Sensor

Biological DNA Sensor
  • Author : Ken Ishii,Choon Kit Tang
  • Publisher : Academic Press
  • Release : 13 November 2017
GET THIS BOOKBiological DNA Sensor

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete

Biological DNA Sensor

Biological DNA Sensor
  • Author : Jan Naujoks,Bastian Opitz
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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The detection of bacterial pathogens by the innate immune system is mediated by various pattern recognition receptors that sense microbial molecules such as cell wall components, virulence factors or nucleic acids. Bacterial DNA is recognized by Toll-like receptor 9 (TLR9) at endosomal compartments and by cyclic GMP-AMP synthase, polymerase III/RIG-I, AIM2-like receptors (ALRs), DNA helicases as well as other incompletely characterized proteins in the host cell cytosol. Depending on the receptor and specific engagement of the adapter molecules MyD88,

Biological DNA Sensor

Biological DNA Sensor
  • Author : Cevayir Coban,Miyuki Tozuka,Nao Jounai,Kouji Kobiyama,Fumihiko Takeshita,Choon Kit Tang,Ken J. Ishii
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Ideal vaccines are expected to give lifetime protection from infectious diseases, and if possible, from allergic diseases, autoimmune diseases and cancer. DNA vaccination was introduced two decades ago as a simple plasmid inoculation method with a capability of inducing both cellular and humoral immune responses. Recent studies have provided insights into the molecular mechanisms by which the double-stranded structure of DNA vaccine induces the activation of type-I interferon (IFN)-mediated innate immune responses via STING/TBK1 complex, similar to cytosolic

Biological DNA Sensor

Biological DNA Sensor
  • Author : Tatsuya Saitoh
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Microbial double-stranded (ds)DNA potently stimulates innate immunity. Stimulator of interferon genes (STING) plays a major role in dsDNA-induced expression of type I interferons (IFNs) and elimination of invading pathogens. After stimulation, STING translocates from the endoplasmic reticulum to cytoplasmic punctate structures where it associates with TANK-binding kinase 1 (TBK1). TBK1 phosphorylates interferon regulatory factor 3 to induce type I IFNs and optineurin to induce autophagy, an intracellular clearance system. Autophagy-related protein, Atg9a, regulates membrane trafficking involved in STING movement and

Biological DNA Sensor

Biological DNA Sensor
  • Author : Rebecca Schmidt,Laurel L. Lenz
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Cyclic dinucleotides (c-di-NMPs), such as c-di-GMP and c-di-AMP were first discovered in bacteria, where they play important roles as second messenger molecules that regulate bacterial cellular functions. In addition, these and other c-di-NMPs exert potent biological effects on mammalian cells, such as the inhibition of cancer cell proliferation, immune cell activation, and the triggering of type I interferon production. Here, we introduce the biology of c-di-NMPs in bacterial systems and review the current state of the literature on their biological

Biological DNA Sensor

Biological DNA Sensor
  • Author : Ann Marshak-Rothstein,Michael P. Cancro
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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In vitro analyses of autoreactive B cells and pDCs clearly demonstrate a critical role for both TLR7 and TLR9 in the detection of endogenous nucleic acid ligands and activation of autoreactive B cells and dendritic cell subsets. Ligands for TLR7 and TLR9 are bound by surface receptors, either the BCR or an FcγR, and then delivered to endolysomal compartments where TLR7 or TLR9 are subsequently engaged, leading to immune activation. However, in vivo analyses of autoimmune-prone mice have revealed

Biological DNA Sensor

Biological DNA Sensor
  • Author : Kenichi Shimada,Timothy R. Crother,Moshe Arditi
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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DNA damage exists in all cellular organisms. While DNA damage is distinguished from mutation, mutation can result from unrepaired DNA. While most DNA damage can be repaired, such repair systems are not 100% efficient. Un-repaired DNA damage accumulates in non-replicating cells, such as neurons or myocytes of adult mammals, and can cause aging. DNA damage can be subdivided into two types: (1) endogenous damage caused by reactive oxygen species (ROS) that are derived from metabolic byproducts and (2) exogenous damage caused by radiation (