Biological DNA Sensor

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

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  • Author : Ken Ishii
  • Publisher : Academic Press
  • Pages : 368 pages
  • ISBN : 0124051685
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBiological DNA Sensor

Biological DNA Sensor

Biological DNA Sensor
  • Author : Ken Ishii,Choon Kit Tang
  • Publisher : Academic Press
  • Release : 30 October 2013
GET THIS BOOKBiological DNA Sensor

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete

Biological DNA Sensor

Biological DNA Sensor
  • Author : Glen N. Barber
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Invading microbes are detected by cellular sensors, the consequences of which result in the production of potent anti-pathogen proteins such as type I interferon (IFN) as well as other cytokines capable of stimulating the adaptive immune response. Examples comprise the RIG-I-like helicase (RLH) and the Toll-like receptor (TLR) families which recognize non-self-pathogen derived molecules (PAMPs) including bacterial lipopolysaccharides as well as nucleic acids. In addition, an endoplasmic reticulum (ER) associated transmembrane protein referred to as STING (for stimulator of interferon

Biological DNA Sensor

Biological DNA Sensor
  • Author : Choon Kit Tang,Cevayir Coban,Shizuo Akira,Ken J. Ishii
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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In this chapter, we reflect on our early understanding of the immunogenic properties of dsDNA and give a chronological account of the journey we have taken to discover the individual cellular DNA sensors which have played important roles in mediating DNA induced inflammation.

Biological DNA Sensor

Biological DNA Sensor
  • Author : Cevayir Coban,Miyuki Tozuka,Nao Jounai,Kouji Kobiyama,Fumihiko Takeshita,Choon Kit Tang,Ken J. Ishii
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
GET THIS BOOKBiological DNA Sensor

Ideal vaccines are expected to give lifetime protection from infectious diseases, and if possible, from allergic diseases, autoimmune diseases and cancer. DNA vaccination was introduced two decades ago as a simple plasmid inoculation method with a capability of inducing both cellular and humoral immune responses. Recent studies have provided insights into the molecular mechanisms by which the double-stranded structure of DNA vaccine induces the activation of type-I interferon (IFN)-mediated innate immune responses via STING/TBK1 complex, similar to cytosolic

Biological DNA Sensor

Biological DNA Sensor
  • Author : Rebecca Schmidt,Laurel L. Lenz
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Cyclic dinucleotides (c-di-NMPs), such as c-di-GMP and c-di-AMP were first discovered in bacteria, where they play important roles as second messenger molecules that regulate bacterial cellular functions. In addition, these and other c-di-NMPs exert potent biological effects on mammalian cells, such as the inhibition of cancer cell proliferation, immune cell activation, and the triggering of type I interferon production. Here, we introduce the biology of c-di-NMPs in bacterial systems and review the current state of the literature on their biological

Biological DNA Sensor

Biological DNA Sensor
  • Author : Sivapriya Kailasan Vanaja,Vijay A.K. Rathinam,Katherine A. Fitzgerald
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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The innate immune response serves as the first line of defense against microbial infections by detecting pathogen-associated molecular patterns through germline-encoded pattern recognition receptors. Proteins of the PYHIN family have gained substantial research focus in recent years as central mediators of innate immune responses induced by cytosolic microbial DNA. Sensing of DNA by PYHINs typically leads to activation of inflammasomes and/or type I interferon responses that are crucial for host defense against invading pathogens. Certain members of the family

Biological DNA Sensor

Biological DNA Sensor
  • Author : Søren R. Paludan,Andrew G. Bowie
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
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Microbial and host DNA are potent stimulators of innate immune responses and have been implicated in both host defense and autoimmune diseases. To date more than 10 immunological sensors of DNA have been proposed, and we are now beginning to understand the functions and mechanism of action of these proposed DNA sensors in host defense and diseases. Much of the current knowledge on DNA sensing has been obtained through studies with herpesviruses. Hence, in this chapter, we review and critically assess

Biological DNA Sensor

Biological DNA Sensor
  • Author : Surya Pandey,Taro Kawai
  • Publisher : Elsevier Inc. Chapters
  • Release : 30 October 2013
GET THIS BOOKBiological DNA Sensor

DNA sensors initiate innate immune responses upon recognition of microbial and self-derived DNA in the intracellular compartments or cytoplasm. These sensors include TLR9, AIM2 like receptors and many other recently identified cytosolic DNA sensors. The otherwise protective nature of host defense by these receptors can turn hostile when they recognize self-DNA through various mechanisms and aberrantly activate DNA sensing pathways leading to unregulated or inappropriate type I IFN production and consequent autoimmune and autoinflammatory diseases. In this chapter, we highlight

Biological and Medical Sensor Technologies

Biological and Medical Sensor Technologies
  • Author : Krzysztof Iniewski
  • Publisher : CRC Press
  • Release : 19 December 2017
GET THIS BOOKBiological and Medical Sensor Technologies

Biological and Medical Sensor Technologies presents contributions from top experts who explore the development and implementation of sensors for various applications used in medicine and biology. Edited by a pioneer in the area of advanced semiconductor materials, the book is divided into two sections. The first part covers sensors for biological applications. Topics include: Advanced sensing and communication in the biological world DNA-derivative architectures for long-wavelength bio-sensing Label-free silicon photonics Quartz crystal microbalance-based biosensors Lab-on-chip technologies for cell-sensing applications Enzyme

Sensors for Chemical and Biological Applications

Sensors for Chemical and Biological Applications
  • Author : Manoj Kumar Ram,Venkat R. Bhethanabotla
  • Publisher : CRC Press
  • Release : 03 October 2018
GET THIS BOOKSensors for Chemical and Biological Applications

In recent years, sensor research has undergone a quiet revolution that will have a significant impact on a broad range of applications in areas such as health care, the environment, energy, food safety, national security, and manufacturing. Sensors for Chemical and Biological Applications discusses in detail the potential of chemical and biological sensors and examines how they are meeting the challenges of chem-bio terrorism by monitoring through enhanced specificity, fast response times, and the ability to determine multiple hazardous substances.

The Science and Applications of Synthetic and Systems Biology

The Science and Applications of Synthetic and Systems Biology
  • Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
  • Publisher : National Academies Press
  • Release : 30 December 2011
GET THIS BOOKThe Science and Applications of Synthetic and Systems Biology

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the

Electrochemical DNA Biosensors

Electrochemical DNA Biosensors
  • Author : Mehmet Sengun Ozsoz
  • Publisher : CRC Press
  • Release : 23 April 2012
GET THIS BOOKElectrochemical DNA Biosensors

This book focuses on the basic electrochemical applications of DNA in various areas, from basic principles to the most recent discoveries. The book comprises theoretical and experimental analysis of various properties of nucleic acids, research methods, and some promising applications. The topics discussed in the book include electrochemical detection of DNA hybridization based on latex/gold nanoparticle and nanotubes; nanomaterial-based electrochemical DNA detection; electrochemical detection of microorganism-based DNA biosensors; gold nanoparticle-based electrochemical DNA biosensors; electrochemical detection of the aptamer-target interaction;

Electrochemical Biosensors

Electrochemical Biosensors
  • Author : Ali A. Ensafi
  • Publisher : Elsevier
  • Release : 25 July 2019
GET THIS BOOKElectrochemical Biosensors

Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the

Enzymology Primer for Recombinant DNA Technology

Enzymology Primer for Recombinant DNA Technology
  • Author : Hyone-Myong Eun
  • Publisher : Elsevier
  • Release : 03 June 1996
GET THIS BOOKEnzymology Primer for Recombinant DNA Technology

Enzymes are indispensable tools in recombinant DNA technology and genetic engineering. This book not only provides information for enzymologists, but does so in a manner that will also aid nonenymologists in making proper use of these biocatalysts in their research. The Enzymology Primer for Recombinant DNA Technology includes information not usually found in the brief descriptions given in most books on recombinant DNA methodology and gene cloning. Provides essential basics as well as up-to-date information on enzymes most commonly used

Handbook of Biosensors and Biosensor Kinetics

Handbook of Biosensors and Biosensor Kinetics
  • Author : Ajit Sadana,Neeti Sadana
  • Publisher : Elsevier
  • Release : 26 August 2010
GET THIS BOOKHandbook of Biosensors and Biosensor Kinetics

Biosensors are essential to an ever-expanding range of applications, including healthcare; drug design; detection of biological, chemical, and toxic agents; environmental monitoring; biotechnology; aviation; physics; oceanography; and the protection of civilian and engineering infrastructures. This book, like the previous five books on biosensors by this author (and one by the co-author), addresses the neglected areas of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces. Topics are covered in a comprehensive fashion, with homogeneous presentation for the benefit of the