Biometals in Neurodegenerative Diseases

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets Written for academic researchers, clinicians and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

Produk Detail:

  • Author : Anthony R. White
  • Publisher : Academic Press
  • Pages : 462 pages
  • ISBN : 0128045639
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBiometals in Neurodegenerative Diseases

Biometals in Neurodegenerative Diseases

Biometals in Neurodegenerative Diseases
  • Author : Anthony R. White,Michael Aschner,Lucio G. Costa,Ashley I. Bush
  • Publisher : Academic Press
  • Release : 28 April 2017
GET THIS BOOKBiometals in Neurodegenerative Diseases

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or

Metals and Neurodegeneration: Restoring the Balance

Metals and Neurodegeneration: Restoring the Balance
  • Author : Anthony R. White,Katja M. Kanninen,Peter J. Crouch
  • Publisher : Frontiers Media SA
  • Release : 02 February 2016
GET THIS BOOKMetals and Neurodegeneration: Restoring the Balance

Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s,

Biometals in Autism Spectrum Disorders

Biometals in Autism Spectrum Disorders
  • Author : Andreas Grabrucker
  • Publisher : Academic Press
  • Release : 08 July 2020
GET THIS BOOKBiometals in Autism Spectrum Disorders

Biometals in Autism Spectrum Disorders will be the first to focus on trace metals and autism. Compared to other references examining ASDs or metallomics, a focused presentation of the findings of abnormal metal homeostasis in ASD has not yet come to be. This book provides for readers an overview of current findings on trace metal biology with respect to its role in ASD etiology and discusses how abnormal trace metal biology may be a common factor of several genetic and

Neurotoxicity of Metals

Neurotoxicity of Metals
  • Author : Michael Aschner,Lucio G. Costa
  • Publisher : Springer
  • Release : 09 September 2017
GET THIS BOOKNeurotoxicity of Metals

Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to

Metal-Based Neurodegeneration

Metal-Based Neurodegeneration
  • Author : Robert Crichton,Roberta Ward
  • Publisher : John Wiley & Sons
  • Release : 04 September 2013
GET THIS BOOKMetal-Based Neurodegeneration

Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a detailed surveyof the molecular origins of neurodegenerative diseases. Eachchapter is dedicated to a specific disease, presenting the latestscientific findings, including details of their biochemicalactors (proteins or peptides), their normal and

Metallomics

Metallomics
  • Author : Yasumitsu Ogra,Takafumi Hirata
  • Publisher : Springer
  • Release : 01 March 2017
GET THIS BOOKMetallomics

This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide

Metallomics

Metallomics
  • Author : Marco Aurélio Zezzi Arruda
  • Publisher : Springer
  • Release : 08 June 2018
GET THIS BOOKMetallomics

This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this

Brain Iron Metabolism and CNS Diseases

Brain Iron Metabolism and CNS Diseases
  • Author : Yan-Zhong Chang
  • Publisher : Springer Nature
  • Release : 27 August 2019
GET THIS BOOKBrain Iron Metabolism and CNS Diseases

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America
  • Author : Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram
  • Publisher : Frontiers Media SA
  • Release : 21 June 2018
GET THIS BOOKHuman and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and

Role of Inflammation in Environmental Neurotoxicity

Role of Inflammation in Environmental Neurotoxicity
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 15 February 2019
GET THIS BOOKRole of Inflammation in Environmental Neurotoxicity

Role of Inflammation in Environmental Neurotoxicity, Volume Three, in this comprehensive serial, addresses contemporary advances in neurotoxicology by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Neuroinflammation (Introduction), Organophosphates, Lead, Manganese, Drugs of abuse, Peripheral vs central inflammation, Air pollution, Developmental neurotoxicity, Ethanol, and the Blood brain barrier, amongst other topics. Provides a unique, first of its kind resource Contributed to by world leaders in

Metal Ions and Neurodegenerative Disorders

Metal Ions and Neurodegenerative Disorders
  • Author : Paolo Zatta
  • Publisher : World Scientific
  • Release : 14 April 2021
GET THIS BOOKMetal Ions and Neurodegenerative Disorders

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration

Zinc Signaling

Zinc Signaling
  • Author : Toshiyuki Fukada,Taiho Kambe
  • Publisher : Springer Nature
  • Release : 18 January 2020
GET THIS BOOKZinc Signaling

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for

Run in the Light

Run in the Light
  • Author : John Mitrofanis
  • Publisher : Morgan & Claypool Publishers
  • Release : 05 August 2019
GET THIS BOOKRun in the Light

Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has

The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine
  • Author : Richard Eugene Frye,Michael Berk
  • Publisher : Springer
  • Release : 20 September 2018
GET THIS BOOKThe Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and