Bioreactor Modeling

Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. Presents a multiphase description of bioreactor modeling Includes a combination of concepts issued from different scientific fields to address a practical issue Provides a detailed description of the population balance concept as applied to biological systems Covers a set of illustrative examples of the interaction between hydrodynamics and biological response

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  • Author : Jerome Morchain
  • Publisher : Elsevier
  • Pages : 218 pages
  • ISBN : 0081011660
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBioreactor Modeling

Bioreactor Modeling

Bioreactor Modeling
  • Author : Jerome Morchain
  • Publisher : Elsevier
  • Release : 06 October 2017
GET THIS BOOKBioreactor Modeling

Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand,

Bioreactors: Process and Analysis

Bioreactors: Process and Analysis
  • Author : Tapobrata Panda
  • Publisher : Tata McGraw-Hill Education
  • Release : 03 August 2021
GET THIS BOOKBioreactors: Process and Analysis

6. Bioreactor modeling -- Model - what is it? -- Definition of lumped and distributed parameter models -- Introduction to a few terminologies and theorems -- Modeling principles -- Steps in modeling -- Fundamental laws used in process modeling -- First-order systems -- Second-order systems -- Complexity of the model -- Parameter sensitivity -- Exercises -- References -- Appendix 6 -- 7. Transport processes in bioreactors -- Introduction -- Heat transfer -- Other parameters influencing transfer operations -- Exercises -- References -- 8. Controls

An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer

An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer
  • Author : Enes Kadic,Theodore J. Heindel
  • Publisher : John Wiley & Sons
  • Release : 14 March 2014
GET THIS BOOKAn Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer

Reviews and compares the major types of bioreactors, defines their pros and cons, and identifies research needs and figures of merit that have yet to be addressed Describes common modes of operation in bioreactors Covers the three common bioreactor types, including stirred-tank bioreactors, bubble column bioreactors, and airlift bioreactors Details less common bioreactors types, including fixed bed bioreactors and novel bioreactor designs Discusses advantages and disadvantages of each bioreactor and provides a procedure for optimal bioreactor selection based on current

Solid-State Fermentation Bioreactors

Solid-State Fermentation Bioreactors
  • Author : David A. Mitchell,Nadia Krieger,Marin Berovic
  • Publisher : Springer Science & Business Media
  • Release : 02 August 2006
GET THIS BOOKSolid-State Fermentation Bioreactors

This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

Bioreactors

Bioreactors
  • Author : Carl-Fredrik Mandenius
  • Publisher : John Wiley & Sons
  • Release : 16 February 2016
GET THIS BOOKBioreactors

In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production,

Control in Bioprocessing

Control in Bioprocessing
  • Author : Pablo A. López Pérez,Ricardo Aguilar López,Ricardo Femat
  • Publisher : John Wiley & Sons
  • Release : 03 March 2020
GET THIS BOOKControl in Bioprocessing

Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation

Computational Modeling in Biomechanics

Computational Modeling in Biomechanics
  • Author : Suvranu De,Farshid Guilak,Mohammad Mofrad
  • Publisher : Springer Science & Business Media
  • Release : 10 March 2010
GET THIS BOOKComputational Modeling in Biomechanics

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum

Fed-Batch Cultures

Fed-Batch Cultures
  • Author : Henry C. Lim,Hwa Sung Shin
  • Publisher : Cambridge University Press
  • Release : 22 April 2013
GET THIS BOOKFed-Batch Cultures

This first book dealing exclusively with every aspect of fed-batch operations, used in most industrially important fermentation and bioreactor operations.

Multiphase Bioreactor Design

Multiphase Bioreactor Design
  • Author : Joaquim M.S. Cabral,Manuel Mota,Johannes Tramper
  • Publisher : CRC Press
  • Release : 20 September 2001
GET THIS BOOKMultiphase Bioreactor Design

Bioreaction engineering is fundamental to the optimization of biotechnological processes and the production of biochemicals by enzymes, microbial, plant and animal cells and higher organisms. A reference text for postgraduate students and researchers in biochemical engineering and bioreactor design, Multiphase Bioreactor Design describes the

Bioreactor System Design

Bioreactor System Design
  • Author : Juan A. Asenjo
  • Publisher : CRC Press
  • Release : 17 November 1994
GET THIS BOOKBioreactor System Design

Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and

Fixed Bed Hybrid Bioreactor

Fixed Bed Hybrid Bioreactor
  • Author : Sushovan Sarkar
  • Publisher : Springer Nature
  • Release : 27 January 2021
GET THIS BOOKFixed Bed Hybrid Bioreactor

This book describes a simplified approach to the modelling and process design of a fixed bed hybrid bioreactor for wastewater treatment. In this work a simplified model for hybrid bioreactor is developed to determine output parameters like exiting substrate concentration in bulk liquid, average substrate flux in the biofilm, effective and total biofilm thickness. The model is based on mass balance of both carbonaceous substrate and biomass under suspended and attached growth simultaneously along with substrate mass transport into the

Computational Modeling in Bioengineering and Bioinformatics

Computational Modeling in Bioengineering and Bioinformatics
  • Author : Nenad Filipovic
  • Publisher : Academic Press
  • Release : 09 October 2019
GET THIS BOOKComputational Modeling in Bioengineering and Bioinformatics

Computational Modeling in Bioengineering and Bioinformatics promotes complementary disciplines that hold great promise for the advancement of research and development in complex medical and biological systems, and in the environment, public health, drug design, and so on. It provides a common platform by bridging these two very important and complementary disciplines into an interactive and attractive forum. Chapters cover biomechanics and bioimaging, biomedical decision support system, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, biomedical