Bioreactor Modeling

Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. Presents a multiphase description of bioreactor modeling Includes a combination of concepts issued from different scientific fields to address a practical issue Provides a detailed description of the population balance concept as applied to biological systems Covers a set of illustrative examples of the interaction between hydrodynamics and biological response

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  • Author : Jerome Morchain
  • Publisher : Elsevier
  • Pages : 218 pages
  • ISBN : 0081011660
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBioreactor Modeling

Bioreactor Modeling

Bioreactor Modeling
  • Author : Jerome Morchain
  • Publisher : Elsevier
  • Release : 06 October 2017
GET THIS BOOKBioreactor Modeling

Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand,

Solid-State Fermentation Bioreactors

Solid-State Fermentation Bioreactors
  • Author : David A. Mitchell,Nadia Krieger,Marin Berovic
  • Publisher : Springer Science & Business Media
  • Release : 02 August 2006
GET THIS BOOKSolid-State Fermentation Bioreactors

This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer

An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer
  • Author : Enes Kadic,Theodore J. Heindel
  • Publisher : John Wiley & Sons
  • Release : 14 March 2014
GET THIS BOOKAn Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer

Reviews and compares the major types of bioreactors, defines their pros and cons, and identifies research needs and figures of merit that have yet to be addressed Describes common modes of operation in bioreactors Covers the three common bioreactor types, including stirred-tank bioreactors, bubble column bioreactors, and airlift bioreactors Details less common bioreactors types, including fixed bed bioreactors and novel bioreactor designs Discusses advantages and disadvantages of each bioreactor and provides a procedure for optimal bioreactor selection based on current

DESIGN, IMPLEMENTATION AND MODELING OF A TRANSTUBULAR BIOREACTOR FOR THE GROWTH OF MAMMALIAN CELLS (BIOREACTOR, HYBRIDOMA CELLS).

DESIGN, IMPLEMENTATION AND MODELING OF A TRANSTUBULAR BIOREACTOR FOR THE GROWTH OF MAMMALIAN CELLS (BIOREACTOR, HYBRIDOMA CELLS).
  • Author : CRAIG REED HALBERSTADT
  • Publisher : Unknown Publisher
  • Release : 06 May 1991
GET THIS BOOKDESIGN, IMPLEMENTATION AND MODELING OF A TRANSTUBULAR BIOREACTOR FOR THE GROWTH OF MAMMALIAN CELLS (BIOREACTOR, HYBRIDOMA CELLS).

antibody production. Whether the increase in antibody production is due to autocrine/paracrine factors, local pH concentrations, pulsatile delivery of growth factors or some other mechanism is unknown and requires further study.

Multiphase Bioreactor Design

Multiphase Bioreactor Design
  • Author : Joaquim M.S. Cabral,Manuel Mota,Johannes Tramper
  • Publisher : CRC Press
  • Release : 20 September 2001
GET THIS BOOKMultiphase Bioreactor Design

Bioreaction engineering is fundamental to the optimization of biotechnological processes and the production of biochemicals by enzymes, microbial, plant and animal cells and higher organisms. A reference text for postgraduate students and researchers in biochemical engineering and bioreactor design, Multiphase Bioreactor Design describes the

Computational Modeling in Biomechanics

Computational Modeling in Biomechanics
  • Author : Suvranu De,Farshid Guilak,Mohammad Mofrad
  • Publisher : Springer Science & Business Media
  • Release : 10 March 2010
GET THIS BOOKComputational Modeling in Biomechanics

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum

Biomass Now

Biomass Now
  • Author : Miodrag Darko Matovic
  • Publisher : BoD – Books on Demand
  • Release : 30 April 2013
GET THIS BOOKBiomass Now

This two-volume book on biomass is a reflection of the increase in biomass related research and applications, driven by overall higher interest in sustainable energy and food sources, by increased awareness of potentials and pitfalls of using biomass for energy, by the concerns for food supply and by multitude of potential biomass uses as a source material in organic chemistry, bringing in the concept of bio-refinery. It reflects the trend in broadening of biomass related research and an increased focus

Bioreactor System Design

Bioreactor System Design
  • Author : Juan A. Asenjo
  • Publisher : CRC Press
  • Release : 17 November 1994
GET THIS BOOKBioreactor System Design

Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and

Computational Modeling in Bioengineering and Bioinformatics

Computational Modeling in Bioengineering and Bioinformatics
  • Author : Nenad Filipovic
  • Publisher : Academic Press
  • Release : 09 October 2019
GET THIS BOOKComputational Modeling in Bioengineering and Bioinformatics

Computational Modeling in Bioengineering and Bioinformatics promotes complementary disciplines that hold great promise for the advancement of research and development in complex medical and biological systems, and in the environment, public health, drug design, and so on. It provides a common platform by bridging these two very important and complementary disciplines into an interactive and attractive forum. Chapters cover biomechanics and bioimaging, biomedical decision support system, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, biomedical

Bioreaction Engineering

Bioreaction Engineering
  • Author : K. Schügerl,K.-H. Bellgardt
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKBioreaction Engineering

Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.

Control in Bioprocessing

Control in Bioprocessing
  • Author : Pablo A. López Pérez,Ricardo Aguilar López,Ricardo Femat
  • Publisher : John Wiley & Sons
  • Release : 03 March 2020
GET THIS BOOKControl in Bioprocessing

Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation

Bioreactors

Bioreactors
  • Author : Goutam Saha,Alok Barua,Satyabroto Sinha
  • Publisher : CRC Press
  • Release : 01 December 2017
GET THIS BOOKBioreactors

Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to

Fixed Bed Hybrid Bioreactor

Fixed Bed Hybrid Bioreactor
  • Author : Sushovan Sarkar
  • Publisher : Springer Nature
  • Release : 27 January 2021
GET THIS BOOKFixed Bed Hybrid Bioreactor

This book describes a simplified approach to the modelling and process design of a fixed bed hybrid bioreactor for wastewater treatment. In this work a simplified model for hybrid bioreactor is developed to determine output parameters like exiting substrate concentration in bulk liquid, average substrate flux in the biofilm, effective and total biofilm thickness. The model is based on mass balance of both carbonaceous substrate and biomass under suspended and attached growth simultaneously along with substrate mass transport into the