Botulinum Neurotoxins

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

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  • Author : Andreas Rummel
  • Publisher : Springer Science & Business Media
  • Pages : 324 pages
  • ISBN : 3642335705
  • Rating : 4/5 from 21 reviews
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Botulinum Neurotoxin and Tetanus Toxin

Botulinum Neurotoxin and Tetanus Toxin
  • Author : Lance Simpson
  • Publisher : Elsevier
  • Release : 02 December 2012
GET THIS BOOKBotulinum Neurotoxin and Tetanus Toxin

Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and

Botulinum Neurotoxins

Botulinum Neurotoxins
  • Author : Andreas Rummel,Thomas Binz
  • Publisher : Springer Science & Business Media
  • Release : 14 December 2012
GET THIS BOOKBotulinum Neurotoxins

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule

Botulinum Toxin E-Book

Botulinum Toxin E-Book
  • Author : Joseph Jankovic,Alberto Albanese,M. Zouhair Atassi,J. Oliver Dolly,Mark Hallett,Nathaniel H. Mayer
  • Publisher : Elsevier Health Sciences
  • Release : 18 February 2009
GET THIS BOOKBotulinum Toxin E-Book

The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat—such as botulinum toxin applications for the treatment of cranial-cervical dystonias,

Botulinum Toxin Treatment

Botulinum Toxin Treatment
  • Author : Bahman Jabbari
  • Publisher : Springer
  • Release : 13 November 2018
GET THIS BOOKBotulinum Toxin Treatment

Very few therapeutic agents in clinical medicine have found indication for so many clinical conditions, and in such a short time as did botulinum neurotoxins (Botox and others). Chronic migraine, bladder dysfunction , dystonia, hemifacial spasm , blepharospasm , drooling, excessive sweating and spasticity are all approved by FDA and many other indications are in the near horizon . The aesthetic/cosmetic use of Botox and other BoNTs already has a huge market worldwide. Stroke, Multiple sclerosis, Parkinson’s disease, Cerebral palsy as well

Clostridial Neurotoxins

Clostridial Neurotoxins
  • Author : Cesare Montecucco
  • Publisher : Springer Science & Business Media
  • Release : 11 November 2013
GET THIS BOOKClostridial Neurotoxins

Tetanus has been known from the very beginning of medical literature since it was first described by Hyppocrates of Cos in the fifth century B.C. For 24 centuries it was considered a neuro logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon strated that the disease is actually an intoxication caused by a proteic neurotoxin. This toxin was shown

Clinical Applications of Botulinum Neurotoxin

Clinical Applications of Botulinum Neurotoxin
  • Author : Keith A. Foster
  • Publisher : Springer
  • Release : 08 July 2014
GET THIS BOOKClinical Applications of Botulinum Neurotoxin

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding

Botulinum Neurotoxin Injection Manual

Botulinum Neurotoxin Injection Manual
  • Author : Katharine E. Alter, MD,Nicole A. Wilson, PhD, MD
  • Publisher : Demos Medical Publishing
  • Release : 15 December 2014
GET THIS BOOKBotulinum Neurotoxin Injection Manual

This comprehensive yet practical guide covers botulinum toxin injections and the wide range of clinical applications for neurologic and other conditions. Intended as both as an introduction for new injectors and a handy reference guide for busy clinicians, the book opens with a brief review of pharmacology, product information and distinctions between the four toxins that are currently approved for use in the U.S. by the FDA, indications and doses for FDA-approved conditions, and accepted and emerging clinical applications.

Botulinum and Tetanus Neurotoxins

Botulinum and Tetanus Neurotoxins
  • Author : B.R. DasGupta
  • Publisher : Springer Science & Business Media
  • Release : 11 November 2013
GET THIS BOOKBotulinum and Tetanus Neurotoxins

Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during

Botulinum Toxin Therapy

Botulinum Toxin Therapy
  • Author : Scott M. Whitcup,Mark Hallett
  • Publisher : Springer Nature
  • Release : 05 January 2021
GET THIS BOOKBotulinum Toxin Therapy

In a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases. Part 1 of the book reviews the basic science of botulinum toxins including advances in our understanding of the molecular structure and mechanism of action of botulinum toxins. This section also discusses the manufacturing and formulation of botulinum toxins for clinical use