Brain Lipids in Synaptic Function and Neurological Disease

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. Written to provide a "hands-on" approach for readers Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings Step-by-step guide to memorize and draw lipid structures Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique

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  • Author : Jacques Fantini
  • Publisher : Academic Press
  • Pages : 398 pages
  • ISBN : 0128004924
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBrain Lipids in Synaptic Function and Neurological Disease

Brain Lipids in Synaptic Function and Neurological Disease

Brain Lipids in Synaptic Function and Neurological Disease
  • Author : Jacques Fantini,Nouara Yahi
  • Publisher : Academic Press
  • Release : 12 May 2015
GET THIS BOOKBrain Lipids in Synaptic Function and Neurological Disease

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology

Omega-3 Fatty Acids in Brain and Neurological Health

Omega-3 Fatty Acids in Brain and Neurological Health
  • Author : Ronald Ross Watson,Fabien De Meester
  • Publisher : Elsevier
  • Release : 25 June 2014
GET THIS BOOKOmega-3 Fatty Acids in Brain and Neurological Health

Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease

Advances in Lipoprotein Research

Advances in Lipoprotein Research
  • Author : Turgay Isbir
  • Publisher : BoD – Books on Demand
  • Release : 29 March 2017
GET THIS BOOKAdvances in Lipoprotein Research

Lipoproteins have key roles in human growth and development, along with promoting, preventing, and/or participating in the pathogenesis or in the treatment of various diseases. This book presents a systematic and comprehensive review about the structure and metabolism of lipoproteins, particularly highlighting the crucial role of those molecules in the body and considering the interest of some lipids in healthy and diseased conditions. This book aims to provide integrative approach to understand the lipoprotein metabolism. Distinguished international experts contributed

Synaptic Function

Synaptic Function
  • Author : Synaptic Function,Neurosciences Institute (New York, N.Y.)
  • Publisher : Wiley-Interscience
  • Release : 07 May 1987
GET THIS BOOKSynaptic Function

This book consists of five sections. The first section details methods for analyzing both presynaptic and postsynaptic function and emphasizes the molecular aspects of synapses. It describes ongoing studies of neurotransmitter release, voltage- sensitive ion channels, and electronic transmission at gap junctions. The second section focuses on the growing menagerie of neurotransmitters: their catagorization into chemical families, their relation to ion channels, their modulation by second messenger systems and their role in pharmacologic action. The third section considers the important

Lipids in Health and Disease

Lipids in Health and Disease
  • Author : Peter Quinn,Xiaoyuan Wang
  • Publisher : Springer Science & Business Media
  • Release : 27 August 2008
GET THIS BOOKLipids in Health and Disease

Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of

Alzheimer's Disease

Alzheimer's Disease
  • Author : Inga Zerr
  • Publisher : BoD – Books on Demand
  • Release : 01 July 2015
GET THIS BOOKAlzheimer's Disease

There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role

An Introduction to Biological Membranes

An Introduction to Biological Membranes
  • Author : William Stillwell
  • Publisher : Elsevier
  • Release : 30 June 2016
GET THIS BOOKAn Introduction to Biological Membranes

Introduction to Biological Membranes: Composition, Structure and Function, Second Edition is a greatly expanded revision of the first edition that integrates many aspects of complex biological membrane functions with their composition and structure. A single membrane is composed of hundreds of proteins and thousands of lipids, all in constant flux. Every aspect of membrane structural studies involves parameters that are very small and fast. Both size and time ranges are so vast that multiple instrumentations must be employed, often simultaneously.

From Neurons to Neighborhoods

From Neurons to Neighborhoods
  • Author : Division of Behavioral and Social Sciences and Education,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
  • Publisher : National Academies Press
  • Release : 13 November 2000
GET THIS BOOKFrom Neurons to Neighborhoods

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from

Polyunsaturated Fatty Acid Metabolism

Polyunsaturated Fatty Acid Metabolism
  • Author : Graham C. Burdge
  • Publisher : Elsevier
  • Release : 04 May 2018
GET THIS BOOKPolyunsaturated Fatty Acid Metabolism

Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This

Synaptic Plasticity

Synaptic Plasticity
  • Author : Thomas Heinbockel
  • Publisher : BoD – Books on Demand
  • Release : 21 June 2017
GET THIS BOOKSynaptic Plasticity

Nerve cells form thousands of contact points, the synapses, to communicate information with other neurons and target cells. Synapses are sites for changes in brain function through modification of synaptic transmission termed synaptic plasticity. The study of synaptic plasticity has flourished over the years with the advancement of technical breakthroughs and is a timely scientific endeavor today just like it was several decades ago. This book contributes to our understanding of synaptic plasticity at the molecular, biochemical, and cellular systems

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release : 24 October 2017
GET THIS BOOKRole of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the

Mapping the Brain and Its Functions

Mapping the Brain and Its Functions
  • Author : Institute of Medicine,Division of Biobehavioral Sciences and Mental Disorders,Division of Health Sciences Policy,Committee on a National Neural Circuitry Database
  • Publisher : National Academies Press
  • Release : 01 February 1991
GET THIS BOOKMapping the Brain and Its Functions

Significant advances in brain research have been made, but investigators who face the resulting explosion of data need new methods to integrate the pieces of the "brain puzzle." Based on the expertise of more than 100 neuroscientists and computer specialists, this new volume examines how computer technology can meet that need. Featuring outstanding color photography, the book presents an overview of the complexity of brain research, which covers the spectrum from human behavior to genetic mechanisms. Advances in vision, substance abuse,

Intracellular Cholesterol Trafficking

Intracellular Cholesterol Trafficking
  • Author : T.Y. Chang,Dale A. Freeman
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKIntracellular Cholesterol Trafficking

INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. In April 1997, many of the authors met for a two-day meeting devoted entirely to intracellular cholesterol trafficking. The rationale for this meeting was that investigators interested in this topic worked in a variety of fields, and rarely, if ever, all met together. Everybody knew each other's papers but mostly worked in isolation from one another. Understanding of cholesterol

Nitric Oxide Synthase

Nitric Oxide Synthase
  • Author : Seyed Soheil Saeedi Saravi
  • Publisher : BoD – Books on Demand
  • Release : 17 May 2017
GET THIS BOOKNitric Oxide Synthase

Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology,