Brain Lipids in Synaptic Function and Neurological Disease

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. Written to provide a "hands-on" approach for readers Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings Step-by-step guide to memorize and draw lipid structures Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique

Produk Detail:

  • Author : Jacques Fantini
  • Publisher : Academic Press
  • Pages : 398 pages
  • ISBN : 0128004924
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBrain Lipids in Synaptic Function and Neurological Disease

Brain Lipids in Synaptic Function and Neurological Disease

Brain Lipids in Synaptic Function and Neurological Disease
  • Author : Jacques Fantini,Nouara Yahi
  • Publisher : Academic Press
  • Release : 12 May 2015
GET THIS BOOKBrain Lipids in Synaptic Function and Neurological Disease

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology

Lipids in Health and Disease

Lipids in Health and Disease
  • Author : Peter Quinn,Xiaoyuan Wang
  • Publisher : Springer Science & Business Media
  • Release : 27 August 2008
GET THIS BOOKLipids in Health and Disease

Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of

Update on Dementia

Update on Dementia
  • Author : Davide Moretti
  • Publisher : BoD – Books on Demand
  • Release : 28 September 2016
GET THIS BOOKUpdate on Dementia

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma

Omega-3 Fatty Acids in Brain and Neurological Health

Omega-3 Fatty Acids in Brain and Neurological Health
  • Author : Ronald Ross Watson,Fabien De Meester
  • Publisher : Elsevier
  • Release : 25 June 2014
GET THIS BOOKOmega-3 Fatty Acids in Brain and Neurological Health

Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease

Beneficial Effects of Fish Oil on Human Brain

Beneficial Effects of Fish Oil on Human Brain
  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release : 14 July 2009
GET THIS BOOKBeneficial Effects of Fish Oil on Human Brain

It is becoming increasingly evident that the deficiency of n-3 fatty acids in diet is not only associated with cardiovascular diseases, but also involved in stroke, epilepsy and other neurological and neurodegenerative diseases, such as Alzheimer disease, Parkinson disease, and peroxisomal diseases. In his newest book, Beneficial Effects of Fish Oil on Human Brain, Dr. Akhlaq A. Farooqui expands on the status and therapeutic importance of n-3 fatty acids (major components of fish oil) and their mediators in normal brain

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases
  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release : 02 September 2010
GET THIS BOOKNeurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release : 24 October 2017
GET THIS BOOKRole of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the

Advances in Lipoprotein Research

Advances in Lipoprotein Research
  • Author : Turgay Isbir
  • Publisher : BoD – Books on Demand
  • Release : 29 March 2017
GET THIS BOOKAdvances in Lipoprotein Research

Lipoproteins have key roles in human growth and development, along with promoting, preventing, and/or participating in the pathogenesis or in the treatment of various diseases. This book presents a systematic and comprehensive review about the structure and metabolism of lipoproteins, particularly highlighting the crucial role of those molecules in the body and considering the interest of some lipids in healthy and diseased conditions. This book aims to provide integrative approach to understand the lipoprotein metabolism. Distinguished international experts contributed

Lipid Mediators and Their Metabolism in the Brain

Lipid Mediators and Their Metabolism in the Brain
  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release : 12 August 2011
GET THIS BOOKLipid Mediators and Their Metabolism in the Brain

Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.

Intracellular Cholesterol Trafficking

Intracellular Cholesterol Trafficking
  • Author : T.Y. Chang,Dale A. Freeman
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKIntracellular Cholesterol Trafficking

INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. In April 1997, many of the authors met for a two-day meeting devoted entirely to intracellular cholesterol trafficking. The rationale for this meeting was that investigators interested in this topic worked in a variety of fields, and rarely, if ever, all met together. Everybody knew each other's papers but mostly worked in isolation from one another. Understanding of cholesterol

Brain Lipids and Cholesterol in Neuropsychiatric Disorders

Brain Lipids and Cholesterol in Neuropsychiatric Disorders
  • Author : Erika Freemantle
  • Publisher : Unknown Publisher
  • Release : 01 August 2021
GET THIS BOOKBrain Lipids and Cholesterol in Neuropsychiatric Disorders

"Neuropsychiatric disorders and suicidal behaviour represent major contributions to mortality in Canada. Among the many factors associated with psychiatric disorders and suicide, alterations in lipids and cholesterol have been demonstrated both peripherally and centrally, supporting their roles as mediating variables in the underlying neuropathology. Cholesterol (CHL) regulation is a complex and dynamic system, and while animal studies also support a mediating role of CHL on brain function, efforts to determine a biological association in humans have achieved only modest gains.

Curcumin for Neurological and Psychiatric Disorders

Curcumin for Neurological and Psychiatric Disorders
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release : 16 March 2019
GET THIS BOOKCurcumin for Neurological and Psychiatric Disorders

Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders. The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus

Neuroglia

Neuroglia
  • Author : Helmut Kettenmann,Bruce R. Ransom
  • Publisher : Oxford University Press
  • Release : 01 August 2021
GET THIS BOOKNeuroglia

Graduate students in neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology will find the book indispensable. It is also a vital companion for researchers in these fields as well as clinicians in neurology, neurosurgery, neuropathology, neuro-oncology, physiatry, and psychiatry."--BOOK JACKET.

Pharmacological Modification of Excitatory Hippocampal Ca1 Synapses in Pathological Models of Neuroinflammation and Alzheimer's Disease

Pharmacological Modification of Excitatory Hippocampal Ca1 Synapses in Pathological Models of Neuroinflammation and Alzheimer's Disease
  • Author : Keng-Yu Chang
  • Publisher : Unknown Publisher
  • Release : 01 August 2021
GET THIS BOOKPharmacological Modification of Excitatory Hippocampal Ca1 Synapses in Pathological Models of Neuroinflammation and Alzheimer's Disease

"An integral component of synaptic transmission is the capacity of synapses to adjust their structural and functional properties in response to the activities of other neurons in a process called synaptic plasticity. Changes in excitatory synapses can occur on dendritic spines, postsynaptic sites of the majority of excitatory synapses in the brain. In many neurodegenerative diseases, dendritic spine dysgenesis is observed; thus knowing what causes spine abnormalities will aid the development of therapies against these diseases. Recent studies suggest that

Molecular Organization of Membranes: Where Biology Meets Biophysics

Molecular Organization of Membranes: Where Biology Meets Biophysics
  • Author : Marek Cebecauer,David Holowka
  • Publisher : Frontiers Media SA
  • Release : 07 February 2018
GET THIS BOOKMolecular Organization of Membranes: Where Biology Meets Biophysics

Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed of lipids and proteins influencing each other. Local membrane composition and properties define its molecular organisation and, in this way, regulate the function of all associated molecules. Therefore, studying interactions of components, biophysical properties and overall membrane dynamics provides essential information on its function in the context of cell activities.