Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells presents chapters by leaders in translational natural killer cell research and bridges the gap between clinical need and basic science by presenting state-of-the-art knowledge on innate immunity and the challenges associated with translating it to practical adoptive immunotherapies. New approaches, such as the genetic engineering of NK cells and their combination with checkpoint blockade therapies are discussed among other potential interventions to improve natural killer cell functionality against targets. In addition, challenges, such as the difficulty in genetically modifying NK cells or a poor understanding of their effect on checkpoint inhibition are included. The book is a key reference and go-to resource for researchers and clinicians who want to understand the current limitations associated with bringing natural killer cell-based immunotherapies to the clinic. Discusses translational aspects from leaders in the field to facilitate readers’ understanding of clinical challenges Addresses important events that occur in patient tumor microenvironments as they pertain to NK cells and how they are, or can be, tackled to overcome immunosuppression of NK cells Focuses on immunometabolism by discussing the metabolic reprogramming that NK cells undergo in solid tumors, including hypoxia, adenosine and other metabolites

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  • Author : Sandro Matosevic
  • Publisher : Academic Press
  • Pages : 200 pages
  • ISBN : 0128208805
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBreaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells
  • Author : Sandro Matosevic
  • Publisher : Academic Press
  • Release : 01 December 2020
GET THIS BOOKBreaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells presents chapters by leaders in translational natural killer cell research and bridges the gap between clinical need and basic science by presenting state-of-the-art knowledge on innate immunity and the challenges associated with translating it to practical adoptive immunotherapies. New approaches, such as the genetic engineering of NK cells and their combination with checkpoint blockade therapies are discussed among other potential interventions to improve natural killer cell functionality against targets. In

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives
  • Author : Jorge Morales-Montor,Mariana Segovia-Mendoza
  • Publisher : Academic Press
  • Release : 14 October 2020
GET THIS BOOKImmunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune

Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 04 October 2019
GET THIS BOOKImproving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to

Renal Cell Carcinoma

Renal Cell Carcinoma
  • Author : Eric A. Klein
  • Publisher : CRC Press
  • Release : 23 April 1993
GET THIS BOOKRenal Cell Carcinoma

This reference brings together all aspects of renal cell carcinoma, and provides a basis for understanding the disease's origin, progression and responses to immunotherapy.;Examining the current status of cytokine, cell-based and chemotherapeutic methods of treatment, this book: discusses the clinical presentation of advanced renal carcinoma and its therapeutic challenges; reviews prognostic factors and the management of renal cell carcinoma occurring with von Hippel-Landau syndrome; summarizes efforts to identify the tumour suppressor gene deleted from chromosome 3 in most renal cell

Cancer Immunotherapy at the Crossroads

Cancer Immunotherapy at the Crossroads
  • Author : James H. Finke,Ronald M. Bukowski
  • Publisher : Springer Science & Business Media
  • Release : 24 November 2003
GET THIS BOOKCancer Immunotherapy at the Crossroads

Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions

Unique Aspects of Anti-cancer Drug Development

Unique Aspects of Anti-cancer Drug Development
  • Author : Jolanta Natalia Latosińska,Magdalena Latosińska
  • Publisher : BoD – Books on Demand
  • Release : 12 July 2017
GET THIS BOOKUnique Aspects of Anti-cancer Drug Development

The evidence of cancer in humans, animals and plant species suggests that it is as old as multicellular life on Earth. Why is it so difficult to understand and fight? Because cancer begins from the organism's own mutated single cell focused on its own survival. It would be naive to expect that cancer could be ever entirely eliminated, but there is still hope for finding effective treatments. The book is to give a view of selected aspects of cancer like

Self and Nonself

Self and Nonself
  • Author : Carlos López-Larrea
  • Publisher : Springer Science & Business Media
  • Release : 07 March 2012
GET THIS BOOKSelf and Nonself

In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in

Autophagy in Immune Response: Impact on Cancer Immunotherapy

Autophagy in Immune Response: Impact on Cancer Immunotherapy
  • Author : Salem Chouaib
  • Publisher : Academic Press
  • Release : 11 May 2020
GET THIS BOOKAutophagy in Immune Response: Impact on Cancer Immunotherapy

Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy
  • Author : Kasuya Hideki,Itzel Bustos Villalobos
  • Publisher : Academic Press
  • Release : 15 January 2021
GET THIS BOOKBreaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy discusses current treatment as well as treatment under investigation in pancreatic cancer. It brings information on how to combine current therapy with treatment under development and/or in clinical trials in order to be able to improve pancreatic cancer survival. Pancreatic cancer has a very low survival rate since it is discovered on late phase, when the patient already presents metastases and surgical options are limited. Currently, there are different modalities to

Autoimmune Liver Diseases

Autoimmune Liver Diseases
  • Author : Edward L. Krawitt,Russell H. Wiesner,Mikio Nishioka
  • Publisher : Elsevier Science Health Science Division
  • Release : 09 May 1998
GET THIS BOOKAutoimmune Liver Diseases

The second edition, which appears seven years after the first, is a more comprehensive text and addresses the many recent advances in basic and clinical science applicable to autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune aspects of viral-, drug- and alcohol-induced liver disease and hepatocellular cancer. Pathogenesis, diagnosis and treatment are discussed in depth in light of current understanding of the molecular mechanisms of autoimmunity as it applies to liver disease.

Natural Killer Cell Protocols

Natural Killer Cell Protocols
  • Author : Kerry S. Campbell,Marco Colonna
  • Publisher : Springer Science & Business Media
  • Release : 09 May 2021
GET THIS BOOKNatural Killer Cell Protocols

In Natural Killer Cell Protocols: Cellular and Molecular Methods, Kerry S. Campbell and Marco Colonna have assembled a comprehensive collection of readily reproducible methods designed to study natural killer (NK) cells from the broadest variety of viewpoints. These include not only classic techniques, but also new approaches to standard methods, newly evolved techniques that have become valuable for specific applications, and unique models for manipulating and studying NK cells. Among the advanced methods covered are those for in vitro transendothelial

Pharmacology of Immunotherapeutic Drugs

Pharmacology of Immunotherapeutic Drugs
  • Author : Clinton B. Mathias,Jeremy P. McAleer,Doreen E. Szollosi
  • Publisher : Springer Nature
  • Release : 18 October 2019
GET THIS BOOKPharmacology of Immunotherapeutic Drugs

Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems

Immunotherapy of Cancer

Immunotherapy of Cancer
  • Author : Mary L. Disis
  • Publisher : Springer Science & Business Media
  • Release : 28 October 2007
GET THIS BOOKImmunotherapy of Cancer

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in