Bursting Neurons and Fading Memories

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

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  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Pages : 170 pages
  • ISBN : 0128019883
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBursting Neurons and Fading Memories

Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories
  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Release : 10 October 2014
GET THIS BOOKBursting Neurons and Fading Memories

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the

Intracellular Consequences of Amyloid in Alzheimer's Disease

Intracellular Consequences of Amyloid in Alzheimer's Disease
  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Release : 21 February 2016
GET THIS BOOKIntracellular Consequences of Amyloid in Alzheimer's Disease

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid

Alzheimer’s Turning Point

Alzheimer’s Turning Point
  • Author : Jack C. de la Torre
  • Publisher : Springer
  • Release : 25 June 2016
GET THIS BOOKAlzheimer’s Turning Point

This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored.

Glia in Health and Disease

Glia in Health and Disease
  • Author : Tania Spohr
  • Publisher : BoD – Books on Demand
  • Release : 20 May 2020
GET THIS BOOKGlia in Health and Disease

The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters.

Aging

Aging
  • Author : Harold Cox
  • Publisher : Dushkin Publishing Group
  • Release : 01 July 2005
GET THIS BOOKAging

This eighteenth edition of ANNUAL EDITIONS: AGING (2006 UPDATE) provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for each section; a topical index; and an instructor’s resource guide with testing materials. USING ANNUAL EDITIONS IN THE CLASSROOM is offered as a practical guide for instructors. ANNUAL EDITIONS titles

Annual Editions

Annual Editions
  • Author : Karen L. Freiberg
  • Publisher : McGraw-Hill/Dushkin
  • Release : 01 December 2002
GET THIS BOOKAnnual Editions

This annually updated reader is a compilation of carefully selected articles from magazines, newspapers, and journals. Topics covered include genetic and parental influences on development, development during infancy and early childhood and many others. This title is supported by Dushkin Online (www.dushkin.com/online/), a student Web site that provides study support and tools and links to related Web sites.

The NEURON Book

The NEURON Book
  • Author : Nicholas T. Carnevale,Michael L. Hines
  • Publisher : Cambridge University Press
  • Release : 12 January 2006
GET THIS BOOKThe NEURON Book

The authoritative reference on NEURON, the simulation environment for modeling biological neurons and neural networks that enjoys wide use in the experimental and computational neuroscience communities. This book shows how to use NEURON to construct and apply empirically based models. Written primarily for neuroscience investigators, teachers, and students, it assumes no previous knowledge of computer programming or numerical methods. Readers with a background in the physical sciences or mathematics, who have some knowledge about brain cells and circuits and are

Annual Editions

Annual Editions
  • Author : Harold Cox
  • Publisher : Annual Editions: Aging
  • Release : 01 July 2003
GET THIS BOOKAnnual Editions

This collection of public press articles were chosen because they address the most relevant and current problems in the field of aging and they present a variety of divergent views on the appropriate solutions to these problems. The well-illustrated articles are written by gerontologists, educators, researchers, and writers, and provide an effective and useful perspective on today's important topics in the study of aging. This title is supported by the student Web site, Dushkin Online (www.dushkin.com/online).

Annual Editions: Aging 08/09

Annual Editions: Aging 08/09
  • Author : Harold Cox
  • Publisher : McGraw-Hill/Dushkin
  • Release : 17 March 2008
GET THIS BOOKAnnual Editions: Aging 08/09

This Twenty-First Edition of ANNUAL EDITIONS: AGING provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for each section; a topical index; and an instructor’s resource guide with testing materials. USING ANNUAL EDITIONS IN THE CLASSROOM, ISBN 0073301906, is offered as a practical guide for instructors. ANNUAL EDITIONS titles

The Brain That Changes Itself

The Brain That Changes Itself
  • Author : Norman Doidge
  • Publisher : Scribe Publications
  • Release : 17 April 2021
GET THIS BOOKThe Brain That Changes Itself

An astonishing new scientific discovery called neuroplasticity is overthrowing the centuries-old notion that the adult human brain is fixed and unchanging. It is, instead, able to change its own structure and function, even into old age. Psychiatrist and rersearcher Norman Doidge, M.D., travelled around the United States to meet the brilliant scientists championing neuroplasticity, and the people whose lives they've transformed — people whose mental limitations or brain damage were previously seen as unalterable, and whose conditions had long been

The Neurobiology of Olfaction

The Neurobiology of Olfaction
  • Author : Anna Menini
  • Publisher : CRC Press
  • Release : 24 November 2009
GET THIS BOOKThe Neurobiology of Olfaction

Comprehensive Overview of Advances in Olfaction The common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely overly simplistic. The Neurobiology of Olfaction provides a thorough analysis of the state-of-the-science in olfactory knowledge and research, reflecting the growing interest in the field. Authors from some

The Functional Role of Critical Dynamics in Neural Systems

The Functional Role of Critical Dynamics in Neural Systems
  • Author : Nergis Tomen,J. Michael Herrmann,Udo Ernst
  • Publisher : Springer
  • Release : 23 July 2019
GET THIS BOOKThe Functional Role of Critical Dynamics in Neural Systems

This book offers a timely overview of theories and methods developed by an authoritative group of researchers to understand the link between criticality and brain functioning. Cortical information processing in particular and brain function in general rely heavily on the collective dynamics of neurons and networks distributed over many brain areas. A key concept for characterizing and understanding brain dynamics is the idea that networks operate near a critical state, which offers several potential benefits for computation and information processing.

Nitric Oxide Synthase

Nitric Oxide Synthase
  • Author : Seyed Soheil Saeedi Saravi
  • Publisher : BoD – Books on Demand
  • Release : 17 May 2017
GET THIS BOOKNitric Oxide Synthase

Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology,

An Alchemy of Mind

An Alchemy of Mind
  • Author : Diane Ackerman
  • Publisher : Simon and Schuster
  • Release : 30 October 2012
GET THIS BOOKAn Alchemy of Mind

From the New York Times bestselling author of The Zookeeper's Wife, an ambitious and enlightening work that combines an artist's eye with a scientist's erudition to illuminate, as never before, the magic and mysteries of the human mind. Long treasured by literary readers for her uncommon ability to bridge the gap between art and science, celebrated scholar-artist Diane Ackerman returns with the book she was born to write. Her dazzling new work, An Alchemy of Mind, offers an unprecedented exploration