Bursting Neurons and Fading Memories

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

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  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Pages : 170 pages
  • ISBN : 0128019883
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBursting Neurons and Fading Memories

Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories
  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Release : 10 October 2014
GET THIS BOOKBursting Neurons and Fading Memories

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the

Intracellular Consequences of Amyloid in Alzheimer's Disease

Intracellular Consequences of Amyloid in Alzheimer's Disease
  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Release : 21 February 2016
GET THIS BOOKIntracellular Consequences of Amyloid in Alzheimer's Disease

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid

Alzheimer’s Turning Point

Alzheimer’s Turning Point
  • Author : Jack C. de la Torre
  • Publisher : Springer
  • Release : 25 June 2016
GET THIS BOOKAlzheimer’s Turning Point

This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored.

Glia in Health and Disease

Glia in Health and Disease
  • Author : Tania Spohr
  • Publisher : BoD – Books on Demand
  • Release : 20 May 2020
GET THIS BOOKGlia in Health and Disease

The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters.

From Neurons to Neighborhoods

From Neurons to Neighborhoods
  • Author : Division of Behavioral and Social Sciences and Education,Institute of Medicine,Board on Children, Youth, and Families,Committee on Integrating the Science of Early Childhood Development
  • Publisher : National Academies Press
  • Release : 13 November 2000
GET THIS BOOKFrom Neurons to Neighborhoods

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from

Annual Editions

Annual Editions
  • Author : Karen L. Freiberg
  • Publisher : McGraw-Hill/Dushkin
  • Release : 01 December 2002
GET THIS BOOKAnnual Editions

This annually updated reader is a compilation of carefully selected articles from magazines, newspapers, and journals. Topics covered include genetic and parental influences on development, development during infancy and early childhood and many others. This title is supported by Dushkin Online (www.dushkin.com/online/), a student Web site that provides study support and tools and links to related Web sites.

The Brain That Changes Itself

The Brain That Changes Itself
  • Author : Norman Doidge
  • Publisher : Scribe Publications
  • Release : 03 August 2021
GET THIS BOOKThe Brain That Changes Itself

An astonishing new scientific discovery called neuroplasticity is overthrowing the centuries-old notion that the adult human brain is fixed and unchanging. It is, instead, able to change its own structure and function, even into old age. Psychiatrist and rersearcher Norman Doidge, M.D., travelled around the United States to meet the brilliant scientists championing neuroplasticity, and the people whose lives they've transformed — people whose mental limitations or brain damage were previously seen as unalterable, and whose conditions had long been

An Alchemy of Mind

An Alchemy of Mind
  • Author : Diane Ackerman
  • Publisher : Simon and Schuster
  • Release : 30 October 2012
GET THIS BOOKAn Alchemy of Mind

From the New York Times bestselling author of The Zookeeper's Wife, an ambitious and enlightening work that combines an artist's eye with a scientist's erudition to illuminate, as never before, the magic and mysteries of the human mind. Long treasured by literary readers for her uncommon ability to bridge the gap between art and science, celebrated scholar-artist Diane Ackerman returns with the book she was born to write. Her dazzling new work, An Alchemy of Mind, offers an unprecedented exploration

Advances in Natural Computation

Advances in Natural Computation
  • Author : Licheng Jiao,Lipo Wang,Xinbo Gao,Jing Liu,Feng Wu
  • Publisher : Springer
  • Release : 28 September 2006
GET THIS BOOKAdvances in Natural Computation

This is volume I of the proceedings of the Second International Conference on Natural Computation, ICNC 2006. After a demanding review process 168 carefully revised full papers and 86 revised short papers were selected from 1915 submissions for presentation in two volumes. This first volume includes 130 papers related to artificial neural networks, natural neural systems and cognitive science, neural network applications, as well as evolutionary computation: theory and algorithms.

Advances in Natural Computation

Advances in Natural Computation
  • Author : Licheng Jiao,Lipo Wang,Xinbo Gao,Jing Liu,Feng Wu
  • Publisher : Springer Science & Business Media
  • Release : 19 September 2006
GET THIS BOOKAdvances in Natural Computation

This is volume I of the proceedings of the Second International Conference on Natural Computation, ICNC 2006. After a demanding review process 168 carefully revised full papers and 86 revised short papers were selected from 1915 submissions for presentation in two volumes. This first volume includes 130 papers related to artificial neural networks, natural neural systems and cognitive science, neural network applications, as well as evolutionary computation: theory and algorithms.

Rewire Your Brain

Rewire Your Brain
  • Author : John B. Arden, PhD
  • Publisher : John Wiley & Sons
  • Release : 22 March 2010
GET THIS BOOKRewire Your Brain

How to rewire your brain to improve virtually every aspect of your life-based on the latest research in neuroscience and psychology on neuroplasticity and evidence-based practices Not long ago, it was thought that the brain you were born with was the brain you would die with, and that the brain cells you had at birth were the most you would ever possess. Your brain was thought to be “hardwired” to function in predetermined ways. It turns out that's not true.

Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers
  • Author : Peter Whittle
  • Publisher : World Scientific Publishing Company
  • Release : 03 August 2021
GET THIS BOOKNeural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels. Design is based on the criterion that an associative memory must be able to cope with 'fading data', i.e., to form an inference from the data even as its memory of that data degrades. The resultant net

The Brain's Way of Healing

The Brain's Way of Healing
  • Author : Norman Doidge
  • Publisher : Penguin
  • Release : 27 January 2015
GET THIS BOOKThe Brain's Way of Healing

NEW YORK TIMES BESTSELLER The New York Times–bestselling author of The Brain That Changes Itself presents astounding advances in the treatment of brain injury and illness. Now in an updated and expanded paperback edition. Winner of the 2015 Gold Nautilus Award in Science & Cosmology In his groundbreaking work The Brain That Changes Itself, Norman Doidge introduced readers to neuroplasticity—the brain’s ability to change its own structure and function in response to activity and mental experience. Now his revolutionary