Cancer and Noncoding RNAs

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

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  • Author : Jayprokas Chakrabarti
  • Publisher : Academic Press
  • Pages : 576 pages
  • ISBN : 0128134372
  • Rating : 5/5 from 1 reviews
CLICK HERE TO GET THIS BOOKCancer and Noncoding RNAs

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs
  • Author : Jayprokas Chakrabarti,Sanga Mitra
  • Publisher : Academic Press
  • Release : 13 October 2017
GET THIS BOOKCancer and Noncoding RNAs

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail

Non-coding RNAs and Cancer

Non-coding RNAs and Cancer
  • Author : Muller Fabbri
  • Publisher : Springer Science & Business Media
  • Release : 28 October 2013
GET THIS BOOKNon-coding RNAs and Cancer

The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive

The Long and Short Non-coding RNAs in Cancer Biology

The Long and Short Non-coding RNAs in Cancer Biology
  • Author : Erwei Song
  • Publisher : Springer
  • Release : 04 July 2016
GET THIS BOOKThe Long and Short Non-coding RNAs in Cancer Biology

The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their

Physiologic and Pathologic Angiogenesis

Physiologic and Pathologic Angiogenesis
  • Author : Dan Simionescu,Agneta Simionescu
  • Publisher : BoD – Books on Demand
  • Release : 05 April 2017
GET THIS BOOKPhysiologic and Pathologic Angiogenesis

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that

Non-coding RNAs in Colorectal Cancer

Non-coding RNAs in Colorectal Cancer
  • Author : Ondrej Slaby,George A. Calin
  • Publisher : Springer
  • Release : 29 August 2016
GET THIS BOOKNon-coding RNAs in Colorectal Cancer

This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of

AGO-Driven Non-Coding RNAs

AGO-Driven Non-Coding RNAs
  • Author : Bibekanand Mallick
  • Publisher : Academic Press
  • Release : 20 January 2019
GET THIS BOOKAGO-Driven Non-Coding RNAs

The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years,

Long Non-Coding RNAs in Cancer

Long Non-Coding RNAs in Cancer
  • Author : Alfons Navarro
  • Publisher : Humana
  • Release : 24 June 2021
GET THIS BOOKLong Non-Coding RNAs in Cancer

This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery

Long Non-coding RNAs in Human Disease

Long Non-coding RNAs in Human Disease
  • Author : Kevin V. Morris
  • Publisher : Springer
  • Release : 13 April 2016
GET THIS BOOKLong Non-coding RNAs in Human Disease

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear

Cancer Genomics

Cancer Genomics
  • Author : Hui Ling,George A. Calin
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

The discovery of microRNA (miRNA) involvement in cancer a decade ago, and the more recent findings of long non-coding RNAs in human diseases, challenged the long-standing view that RNAs without protein-coding potential are simply “junk” transcription within the human genome. These findings evidently changed the dogma that “DNA makes RNA makes protein” by showing that RNAs themselves can be essential regulators of cellular function and play key roles in cancer development. MiRNAs are evolutionarily conserved short single-stranded transcripts of 19–24 nucleotides

MicroRNAs in Cancer

MicroRNAs in Cancer
  • Author : César López-Camarillo,Laurence A. Marchat
  • Publisher : CRC Press
  • Release : 22 February 2013
GET THIS BOOKMicroRNAs in Cancer

MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from

Epigenetics Methods

Epigenetics Methods
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release : 08 July 2020
GET THIS BOOKEpigenetics Methods

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used

Roles of MicroRNAs and Other Noncoding RNAs in Cancer

Roles of MicroRNAs and Other Noncoding RNAs in Cancer
  • Author : Applied Research Applied Research Press
  • Publisher : Unknown Publisher
  • Release : 05 November 2015
GET THIS BOOKRoles of MicroRNAs and Other Noncoding RNAs in Cancer

MicroRNAs (miRNAs) are short, noncoding RNAs that bind mRNAs through partial base-pair complementarity with their target genes, resulting in post-transcriptional repression of gene expression. This thematic series delves into the cancer-specific functions of miRNAs and other noncoding RNAs, including lncRNAs, piRNAs, and ceRNAs, as well as RNAi. While many miRNAs have been shown to play a role in various cancers, other noncoding RNAs have only recently been identified to play a role, as well. Proposed and validated functions are discussed

Epigenetics in Psychiatry

Epigenetics in Psychiatry
  • Author : Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
  • Publisher : Elsevier
  • Release : 23 June 2014
GET THIS BOOKEpigenetics in Psychiatry

Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology

Mitochondrial DNA

Mitochondrial DNA
  • Author : Herve Seligmann,Ganesh Warthi
  • Publisher : BoD – Books on Demand
  • Release : 31 October 2018
GET THIS BOOKMitochondrial DNA

The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. Studies of mitogenomes reveal the details of molecular organization and its evolution under constraints for miniaturization.