Cancer Drug Design and Discovery

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories

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  • Author : Stephen Neidle
  • Publisher : Elsevier
  • Pages : 496 pages
  • ISBN : 9780080554952
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCancer Drug Design and Discovery

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery
  • Author : Stephen Neidle
  • Publisher : Elsevier
  • Release : 28 April 2011
GET THIS BOOKCancer Drug Design and Discovery

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery
  • Author : Stephen Neidle
  • Publisher : Academic Press
  • Release : 30 September 2013
GET THIS BOOKCancer Drug Design and Discovery

Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and

Textbook of Drug Design and Discovery, Third Edition

Textbook of Drug Design and Discovery, Third Edition
  • Author : Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen
  • Publisher : CRC Press
  • Release : 25 July 2002
GET THIS BOOKTextbook of Drug Design and Discovery, Third Edition

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for

Molecular Cancer Therapeutics

Molecular Cancer Therapeutics
  • Author : George C. Prendergast
  • Publisher : John Wiley & Sons
  • Release : 02 April 2004
GET THIS BOOKMolecular Cancer Therapeutics

Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release : 16 April 2019
GET THIS BOOKAnimal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics
  • Author : Gerda Egger,Paola Arimondo
  • Publisher : Academic Press
  • Release : 19 November 2015
GET THIS BOOKDrug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin

In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development

In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development
  • Author : Dhanya Sunil,Pooja R Kamath,Raghu Chandrashekhar H
  • Publisher : CRC Press
  • Release : 18 May 2017
GET THIS BOOKIn Vitro Bioassay Techniques for Anticancer Drug Discovery and Development

This comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials. In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development covers the screening and evaluation of potential drug candidates in a wide category of anticancer assays demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response
  • Author : Federico Innocenti
  • Publisher : Springer Science & Business Media
  • Release : 30 October 2008
GET THIS BOOKGenomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients,

Conference on Drug Design and Discovery Technologies

Conference on Drug Design and Discovery Technologies
  • Author : Manikanta Murahari,Lakshmi Sundar,Soma Chaki,Vasanthanathan Poongavanam,Pritesh Bhat,Usha Y Nayak
  • Publisher : Royal Society of Chemistry
  • Release : 20 November 2019
GET THIS BOOKConference on Drug Design and Discovery Technologies

This publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the

Drug Discovery and Development, Third Edition

Drug Discovery and Development, Third Edition
  • Author : James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell
  • Publisher : CRC Press
  • Release : 13 December 2019
GET THIS BOOKDrug Discovery and Development, Third Edition

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the

Small Molecule Drug Discovery

Small Molecule Drug Discovery
  • Author : Andrea Trabocchi,Elena Lenci
  • Publisher : Elsevier
  • Release : 23 November 2019
GET THIS BOOKSmall Molecule Drug Discovery

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The

Anticancer Drug Development

Anticancer Drug Development
  • Author : Bruce C. Baguley,David J. Kerr
  • Publisher : Elsevier
  • Release : 17 November 2001
GET THIS BOOKAnticancer Drug Development

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects

Systems Biology in Cancer Research and Drug Discovery

Systems Biology in Cancer Research and Drug Discovery
  • Author : Asfar S Azmi
  • Publisher : Springer Science & Business Media
  • Release : 29 September 2012
GET THIS BOOKSystems Biology in Cancer Research and Drug Discovery

Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and