Cancer Genomics

Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

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  • Author : Graham Dellaire
  • Publisher : Academic Press
  • Pages : 510 pages
  • ISBN : 0123972744
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCancer Genomics

Cancer Genomics

Cancer Genomics
  • Author : Graham Dellaire,Jason N Berman,Robert J. Arceci
  • Publisher : Academic Press
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase

Cancer Genomics

Cancer Genomics
  • Author : Katayoon Kasaian,Yvonne Y. Li,Steven J.M. Jones
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

Advances in high-throughput sequencing technologies have enabled cost-effective sequencing of a single human genome at an unprecedented rate, facilitating scientific endeavours never imagined possible before. These improvements have transformed the field of cancer genomics, allowing the complete molecular characterization of individual cancer genomes. However, the promise of unveiling the complexity of cancer has lent itself to yet another level of complexity, the task of managing and integrating the massive amount of data that is generated as part of such experiments.

Cancer Genomics for the Clinician

Cancer Genomics for the Clinician
  • Author : Ramaswamy Govindan, MD,Ashiq Masood, MD
  • Publisher : Springer Publishing Company
  • Release : 28 January 2019
GET THIS BOOKCancer Genomics for the Clinician

Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips

Cancer Genomics and Proteomics

Cancer Genomics and Proteomics
  • Author : Paul B. Fisher
  • Publisher : Humana Press
  • Release : 19 November 2010
GET THIS BOOKCancer Genomics and Proteomics

Cancer Genomics and Proteomics provides a compendium of techniques and applications in gene identification and function. The approaches described in detail are state-of-the art and can be tailored to individual ongoing or planned research projects. This volume is a valuable laboratory resource for designing experiments to identify and analyze genes that are relevant to complex biological phenomena.

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing
  • Author : Khalid El Bairi
  • Publisher : Springer Nature
  • Release : 28 September 2020
GET THIS BOOKIlluminating Colorectal Cancer Genomics by Next-Generation Sequencing

This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the

Cancer Genomics

Cancer Genomics
  • Author : Graham Dellaire,Robert J. Arceci
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

From the first descriptions of cancer in Egypt around 3000 BC to our current “one week” whole-genome sequence, the history of integrating new ideas into the practice of medicine has been unrelenting, although not without its failures as well its successes. This chapter represents a brief historical summary of some of the key success stories in our understanding of cancer that has led to our current age of cancer genomics. As the Chinese proverb states, “When you drink from the well,

Cancer Genomics

Cancer Genomics
  • Author : Hye-Jung E. Chun,Jaswinder Khattra,Martin Krzywinski,Samuel A. Aparicio,Marco A. Marra
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

Cancer results from accumulated mutations in the genome. Sequencing is an accurate method to detect mutations. Second-generation sequencing technology, commonly referred to as next-generation sequencing technology, enables rapid, efficient and affordable DNA sequencing, and is transforming the scale and scope of cancer research. The technology is sufficiently flexible and affordable to allow sequencing of many cancer genomes, and thus facilitates both sequencing of samples from large patient cohorts and during disease progression in individual cancer patients. The high depths of

Cancer Genomics

Cancer Genomics
  • Author : Michael Fraser,Alejandro Berlin,Veronique Ouellet,Fred Saad,Robert G. Bristow
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

Prostate cancer (CaP) is the most commonly diagnosed malignancy in men in the Western world. In North America, more than 275000 men are diagnosed annually whereby approximately 1 in 6 men will be diagnosed with CaP in their lifetime, and 1 in 34 men will die from castrate-resistant metastatic disease. Unfortunately, current clinical prognostic factors explain only a proportion of the observed variation in clinical outcome from patient to patient. Furthermore, over-treatment of indolent and low-risk cancers leads to inappropriate morbidity following radiotherapy or surgery.

Cancer Genomics

Cancer Genomics
  • Author : Matthew Herder,Conrad V Fernandez
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

Large-scale cancer genomics research projects raise a range of ethical and legal issues. We focus on two emerging themes challenged within genomic research: (1) issues surrounding the return of research results to research participants, whether in summary or individualized form, and (2) issues connected to the commercialization of research, including the patenting of biomedical discoveries and biological materials. We examine current thinking in these areas and highlight areas for further exploration.

Cancer Genomics

Cancer Genomics
  • Author : Ulrich Pfeffer
  • Publisher : Springer Science & Business Media
  • Release : 12 February 2013
GET THIS BOOKCancer Genomics

The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely

Cancer Genomics

Cancer Genomics
  • Author : Louise Parker
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

The number of people diagnosed with cancer each year will almost double to 21 million cases worldwide by 2030 because of the aging population. Studies of the human genome have demonstrated that as few as 5–10% of adult cancers are due to genetic inheritance. Over 90% of cancers are due to endogenous or exogenous exposure to chemicals and radiation; many of these carcinogenic exposures, to tobacco smoke, for example, are avoidable and thus the consequent disease is preventable. The “exposome” is the concept which

Cancer Genomics

Cancer Genomics
  • Author : Robert L. Strausberg
  • Publisher : IOS Press
  • Release : 03 August 2021
GET THIS BOOKCancer Genomics

This volume explores the genomics of cancer. Contributions explain how advances in biomedical research in the 1990s launched the genomics era - we are no longer satisfied to study a gene or gene product in isolation, but rather we strive to view each gene within the complex circuitry of a cell. In rapid succession, this mindset has invigorated the analysis of all molecular entities, from the genome, to transcripts (transciptome) and proteins (proteome).

Cancer Genomics

Cancer Genomics
  • Author : Matthew Parker,Erin Hedlund,Jinghui Zhang
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

The vast amount of genomic data being produced by the research community is becoming readily accessible to biomedical researchers and clinicians to apply to their cancer(s) of interest. The major cancer genome projects, among others, The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC) and the Pediatric Cancer Genome Project (PCGP) are contributing to this genomic data goldmine by sequencing hundreds to thousands of cancer genomes and supplementing these data with analyses such as gene expression and

Cancer Genetics and Genomics for Personalized Medicine

Cancer Genetics and Genomics for Personalized Medicine
  • Author : Il-Jin Kim
  • Publisher : CRC Press
  • Release : 11 April 2017
GET THIS BOOKCancer Genetics and Genomics for Personalized Medicine

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine
  • Author : Nosheen Masood,Saima Shakil Malik
  • Publisher : Springer Nature
  • Release : 20 March 2020
GET THIS BOOK'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology