Cancer Genomics

Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

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  • Author : Graham Dellaire
  • Publisher : Academic Press
  • Pages : 510 pages
  • ISBN : 0123972744
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCancer Genomics

Cancer Genomics

Cancer Genomics
  • Author : Graham Dellaire,Jason N Berman,Robert J. Arceci
  • Publisher : Academic Press
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase

Cancer Genetics and Genomics for Personalized Medicine

Cancer Genetics and Genomics for Personalized Medicine
  • Author : Il-Jin Kim
  • Publisher : CRC Press
  • Release : 11 April 2017
GET THIS BOOKCancer Genetics and Genomics for Personalized Medicine

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and

Cancer Genomics for the Clinician

Cancer Genomics for the Clinician
  • Author : Ramaswamy Govindan, MD,Ashiq Masood, MD
  • Publisher : Springer Publishing Company
  • Release : 28 January 2019
GET THIS BOOKCancer Genomics for the Clinician

Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips

Cancer Genomics and Proteomics

Cancer Genomics and Proteomics
  • Author : Paul B. Fisher
  • Publisher : Humana Press
  • Release : 27 September 2007
GET THIS BOOKCancer Genomics and Proteomics

Cancer Genomics and Proteomics provides a compendium of techniques and applications in gene identification and function. The approaches described in detail are state-of-the art and can be tailored to individual ongoing or planned research projects. This volume is a valuable laboratory resource for designing experiments to identify and analyze genes that are relevant to complex biological phenomena.

Cancer Genomics and Proteomics

Cancer Genomics and Proteomics
  • Author : Narendra Wajapeyee
  • Publisher : Humana Press
  • Release : 17 September 2016
GET THIS BOOKCancer Genomics and Proteomics

Cancer Genomics and Proteomics: Methods and Protocols, Second Edition includes methods for the analyses of cancer genome and proteome that have illuminated us about the changes in cancer cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Genomics and Proteomics: Methods and Protocols, Second Edition

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine
  • Author : Nosheen Masood,Saima Shakil Malik
  • Publisher : Springer Nature
  • Release : 20 March 2020
GET THIS BOOK'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology

Collaborative Genomics Projects: A Comprehensive Guide

Collaborative Genomics Projects: A Comprehensive Guide
  • Author : Margi Sheth,Julia Zhang,Jean C Zenklusen
  • Publisher : Academic Press
  • Release : 24 February 2016
GET THIS BOOKCollaborative Genomics Projects: A Comprehensive Guide

Collaborative Genomics Projects: A Comprehensive Guide contains operational procedures, policy considerations, and the many lessons learned by The Cancer Genome Atlas Project. This book guides the reader through methods in patient sample acquisition, the establishment of data generation and analysis pipelines, data storage and dissemination, quality control, auditing, and reporting. This book is essential for those looking to set up or collaborate within a large-scale genomics research project. All authors are contributors to The Cancer Genome Atlas (TCGA) Program, a

The Genetics of Cancer

The Genetics of Cancer
  • Author : B.A. Ponder,M.J. Waring
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKThe Genetics of Cancer

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development.

Oncogenomics

Oncogenomics
  • Author : Franco Dammacco,Franco Silvestris
  • Publisher : Academic Press
  • Release : 30 October 2018
GET THIS BOOKOncogenomics

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists,

Cancer Genomics

Cancer Genomics
  • Author : Ulrich Pfeffer
  • Publisher : Springer Science & Business Media
  • Release : 12 February 2013
GET THIS BOOKCancer Genomics

The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely

Cancer Genomics

Cancer Genomics
  • Author : Michael Fraser,Alejandro Berlin,Veronique Ouellet,Fred Saad,Robert G. Bristow
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

Prostate cancer (CaP) is the most commonly diagnosed malignancy in men in the Western world. In North America, more than 275000 men are diagnosed annually whereby approximately 1 in 6 men will be diagnosed with CaP in their lifetime, and 1 in 34 men will die from castrate-resistant metastatic disease. Unfortunately, current clinical prognostic factors explain only a proportion of the observed variation in clinical outcome from patient to patient. Furthermore, over-treatment of indolent and low-risk cancers leads to inappropriate morbidity following radiotherapy or surgery.

Cancer Genomics

Cancer Genomics
  • Author : Matthew Parker,Erin Hedlund,Jinghui Zhang
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

The vast amount of genomic data being produced by the research community is becoming readily accessible to biomedical researchers and clinicians to apply to their cancer(s) of interest. The major cancer genome projects, among others, The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC) and the Pediatric Cancer Genome Project (PCGP) are contributing to this genomic data goldmine by sequencing hundreds to thousands of cancer genomes and supplementing these data with analyses such as gene expression and

Cancer Genomics

Cancer Genomics
  • Author : Shile Zhang,Jun S. Wei,Javed Khan
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

The complexity of the transcriptome has been appreciated in recent years in light of the Encyclopedia of DNA Elements (ENCODE) project. While less than 3% of the genome is annotated with protein-coding genes, 62% of the genome is long RNA molecules (>200 nucleotides). With an increasing sequencing throughput and a decreasing cost, RNA sequencing (RNA-seq) is becoming a frequently used technology in transcriptome research. This chapter summarizes the advantages of RNA-seq compared to hybridization-based microarrays, the RNA-seq experiment workflow and reviews current applications

Cancer Genomics

Cancer Genomics
  • Author : Hye-Jung E. Chun,Jaswinder Khattra,Martin Krzywinski,Samuel A. Aparicio,Marco A. Marra
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOKCancer Genomics

Cancer results from accumulated mutations in the genome. Sequencing is an accurate method to detect mutations. Second-generation sequencing technology, commonly referred to as next-generation sequencing technology, enables rapid, efficient and affordable DNA sequencing, and is transforming the scale and scope of cancer research. The technology is sufficiently flexible and affordable to allow sequencing of many cancer genomes, and thus facilitates both sequencing of samples from large patient cohorts and during disease progression in individual cancer patients. The high depths of