Cancer Leading Proteases

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

Produk Detail:

  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Pages : 526 pages
  • ISBN : 0128181680
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCancer Leading Proteases

Cancer-Leading Proteases

Cancer-Leading Proteases
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release : 03 February 2020
GET THIS BOOKCancer-Leading Proteases

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating

Proteases in Human Diseases

Proteases in Human Diseases
  • Author : Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer
  • Release : 13 July 2017
GET THIS BOOKProteases in Human Diseases

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse

Kallikrein-related Peptidases

Kallikrein-related Peptidases
  • Author : Viktor Magdolen,Christian P. Sommerhoff,Hans Fritz,Manfred Schmitt
  • Publisher : Unknown Publisher
  • Release : 07 May 2021
GET THIS BOOKKallikrein-related Peptidases

The KLK proteins and their encoding genes are increasingly attracting attention among scientists and clinicians worldwide as they represent interesting and functionally distinct biomarkers both under physiological and pathophysiological conditions. This volume on kallikrein-related peptidases (KLKs) reviews the characterization, regulation, and interactions of these proteases within the protease web.

The Exocrine Pancreas

The Exocrine Pancreas
  • Author : Stephen J. Pandol
  • Publisher : Morgan & Claypool Publishers
  • Release : 07 May 2021
GET THIS BOOKThe Exocrine Pancreas

The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and

Osteoarthritis

Osteoarthritis
  • Author : Qian Chen
  • Publisher : BoD – Books on Demand
  • Release : 01 July 2015
GET THIS BOOKOsteoarthritis

The most common form of arthritis is osteoarthritis (OA), which most often affects the hip, knee, foot and hand. The degeneration of joint cartilage and changes in underlying bone and supporting tissues such as ligament leads to pain, stiffness, movement problems and activity limitations. This book, containing three major sections in OA research and therapy, is an update of the book Osteoarthritis - Diagnosis, Treatment and Surgery published by InTech in 2012. The authors are experts in the osteoarthritis field, which

Ovarian Cancer

Ovarian Cancer
  • Author : Omer Devaja,Andreas Papadopoulos
  • Publisher : BoD – Books on Demand
  • Release : 24 October 2018
GET THIS BOOKOvarian Cancer

Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

An Integrated View of the Molecular Recognition and Toxinology

An Integrated View of the Molecular Recognition and Toxinology
  • Author : Gandhi Radis-Baptista
  • Publisher : BoD – Books on Demand
  • Release : 01 July 2013
GET THIS BOOKAn Integrated View of the Molecular Recognition and Toxinology

Molecular Toxinology has been consolidated as a scientific area focused on the intertwined description of several aspects of animal toxins. In an inquiring biotechnological world, animal toxins appear as an invaluable source for the discovery of therapeutic polypeptides. Animal toxins rely on specific chemical interactions with their partner molecule to exert their biological actions. The comprehension of how molecules interact and recognize their target is essential for the rational exploration of bioactive polypeptides as therapeutics. Investigation on the mechanism of

Tight Junctions

Tight Junctions
  • Author : Marcelino Cereijido,James M. Anderson
  • Publisher : CRC Press
  • Release : 26 June 2001
GET THIS BOOKTight Junctions

As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field. Since its publication in 1992, there has been an explosion of information about tight junctions, particularly in the area of molecular structure, cell and molecular biology, genetics and physiology. The field has advanced so fast and so far that it influences many areas of biology and now has practical implications for pharmacology of drug delivery and

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
  • Author : Wolfgang B. Liedtke, MD, PH.D.
  • Publisher : CRC Press
  • Release : 29 September 2006
GET THIS BOOKTRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized,

Pathophysiological Aspects of Proteases

Pathophysiological Aspects of Proteases
  • Author : Sajal Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer
  • Release : 15 November 2017
GET THIS BOOKPathophysiological Aspects of Proteases

This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making

Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release : 03 July 2017
GET THIS BOOKViral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the

Prostate Cancer

Prostate Cancer
  • Author : Ravinder Mohan
  • Publisher : BoD – Books on Demand
  • Release : 28 September 2016
GET THIS BOOKProstate Cancer

Prostate cancer is diagnosed commonly in the course of general health screening. Very often it is difficult to tell whether the cancer will be aggressive and lethal or will be so slow growing that it will not affect the patient's survival. Treatment can have a major impact on the patient's health-related quality of life. This book presents cutting-edge research in predicting the behavior of localized and metastatic cancer, targeted treatment of cancer that has spread minimally, response to newer methods

Bone Cancer

Bone Cancer
  • Author : Dominique Heymann
  • Publisher : Elsevier
  • Release : 04 September 2014
GET THIS BOOKBone Cancer

Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary

Anticancer Drug Development

Anticancer Drug Development
  • Author : Bruce C. Baguley,David J. Kerr
  • Publisher : Elsevier
  • Release : 17 November 2001
GET THIS BOOKAnticancer Drug Development

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects