Cancer Leading Proteases

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

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  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Pages : 526 pages
  • ISBN : 0128181680
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCancer Leading Proteases

Cancer-Leading Proteases

Cancer-Leading Proteases
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release : 03 February 2020
GET THIS BOOKCancer-Leading Proteases

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating

Adult Stem Cell Niches

Adult Stem Cell Niches
  • Author : Sabine Wislet
  • Publisher : BoD – Books on Demand
  • Release : 01 August 2014
GET THIS BOOKAdult Stem Cell Niches

Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the

Extracellular Matrix Degradation

Extracellular Matrix Degradation
  • Author : William C. Parks,Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release : 07 April 2011
GET THIS BOOKExtracellular Matrix Degradation

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases,

Essentials of Glycobiology

Essentials of Glycobiology
  • Author : Ajit Varki,Maarten J. Chrispeels
  • Publisher : CSHL Press
  • Release : 24 July 1999
GET THIS BOOKEssentials of Glycobiology

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease
  • Author : U. s. Department of Health and Human Services Staff
  • Publisher : U.S. Government Printing Office
  • Release : 24 July 2021
GET THIS BOOKHow Tobacco Smoke Causes Disease

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is

Ovarian Cancer

Ovarian Cancer
  • Author : Omer Devaja,Andreas Papadopoulos
  • Publisher : BoD – Books on Demand
  • Release : 24 October 2018
GET THIS BOOKOvarian Cancer

Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

The Exocrine Pancreas

The Exocrine Pancreas
  • Author : Stephen J. Pandol
  • Publisher : Morgan & Claypool Publishers
  • Release : 24 July 2021
GET THIS BOOKThe Exocrine Pancreas

The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and

Prostate Cancer

Prostate Cancer
  • Author : Ravinder Mohan
  • Publisher : BoD – Books on Demand
  • Release : 28 September 2016
GET THIS BOOKProstate Cancer

Prostate cancer is diagnosed commonly in the course of general health screening. Very often it is difficult to tell whether the cancer will be aggressive and lethal or will be so slow growing that it will not affect the patient's survival. Treatment can have a major impact on the patient's health-related quality of life. This book presents cutting-edge research in predicting the behavior of localized and metastatic cancer, targeted treatment of cancer that has spread minimally, response to newer methods

Proteasome Inhibitors in Cancer Therapy

Proteasome Inhibitors in Cancer Therapy
  • Author : Julian Adams
  • Publisher : Springer Science & Business Media
  • Release : 25 May 2004
GET THIS BOOKProteasome Inhibitors in Cancer Therapy

A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB

Bone Cancer

Bone Cancer
  • Author : Dominique Heymann
  • Publisher : Elsevier
  • Release : 04 September 2014
GET THIS BOOKBone Cancer

Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary

Anticancer Drug Development

Anticancer Drug Development
  • Author : Bruce C. Baguley,David J. Kerr
  • Publisher : Elsevier
  • Release : 17 November 2001
GET THIS BOOKAnticancer Drug Development

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects

Kallikrein-related Peptidases

Kallikrein-related Peptidases
  • Author : Viktor Magdolen
  • Publisher : De Gruyter
  • Release : 24 July 2021
GET THIS BOOKKallikrein-related Peptidases

The KLK proteins and their encoding genes are increasingly attracting attention among scientists and clinicians worldwide as they represent interesting and functionally distinct biomarkers both under physiological and pathophysiological conditions. This volume on kallikrein-related peptidases (KLKs) reviews the characterization, regulation, and interactions of these proteases within the protease web.

Cell Death

Cell Death
  • Author : Tobias Ntuli
  • Publisher : BoD – Books on Demand
  • Release : 16 December 2015
GET THIS BOOKCell Death

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Pathophysiological Aspects of Proteases

Pathophysiological Aspects of Proteases
  • Author : Sajal Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer
  • Release : 15 November 2017
GET THIS BOOKPathophysiological Aspects of Proteases

This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making