Carbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.

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  • Author : Vinod K. Tiwari
  • Publisher : Elsevier
  • Pages : 714 pages
  • ISBN : 0128166762
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCarbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development
  • Author : Vinod K. Tiwari
  • Publisher : Elsevier
  • Release : 31 July 2020
GET THIS BOOKCarbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the

Carbohydrate-based Drug Discovery

Carbohydrate-based Drug Discovery
  • Author : Chi-Huey Wong
  • Publisher : John Wiley & Sons
  • Release : 06 March 2006
GET THIS BOOKCarbohydrate-based Drug Discovery

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume

Carbohydrates in Drug Design and Discovery

Carbohydrates in Drug Design and Discovery
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  • Publisher : Royal Society of Chemistry
  • Release : 30 March 2015
GET THIS BOOKCarbohydrates in Drug Design and Discovery

In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections,

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  • Author : Peter H. Seeberger,Christoph Rademacher
  • Publisher : Springer
  • Release : 14 November 2014
GET THIS BOOKCarbohydrates as Drugs

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series

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  • Publisher : Elsevier
  • Release : 23 November 2019
GET THIS BOOKSmall Molecule Drug Discovery

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The

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  • Author : Shashank Kumar
  • Publisher : CRC Press
  • Release : 01 November 2020
GET THIS BOOKClinical Biochemistry and Drug Development

This new volume focuses on clinical biochemistry fundamentals, cell culture techniques, and drug discovery and development concepts. It deals with three different fields of clinical research: cell culture, clinical biochemistry, and drug discovery and development. The book introduces cell animal and bacterial culture techniques and their potential uses as well as cell culture techniques. The biochemistry aspect of the book covers the principles of clinical biochemistry and biochemical analysis, biochemical aids to clinical diagnosis, measurement, and quality control. The book

Discovery and Development of Antidiabetic Agents from Natural Products

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  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release : 11 October 2016
GET THIS BOOKDiscovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning

Comprehensive Medicinal Chemistry II

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  • Author : David J Triggle,John B Taylor
  • Publisher : Elsevier
  • Release : 29 December 2006
GET THIS BOOKComprehensive Medicinal Chemistry II

The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry

Chitin and Chitosan Derivatives

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  • Author : Se-Kwon Kim
  • Publisher : CRC Press
  • Release : 04 December 2013
GET THIS BOOKChitin and Chitosan Derivatives

A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and internal shells of cephalopods. However, marine crustacean shells are the primary sources of the chitin derivative chitosan. Chitin and chitosan are useful for various biological and biomedical applications, although they have been limited by poor solubility in the past. Current research focuses on increasing their solubility and bioactivity through

Carbohydrate Recognition

Carbohydrate Recognition
  • Author : Binghe Wang,Geert-Jan Boons
  • Publisher : John Wiley & Sons
  • Release : 09 September 2011
GET THIS BOOKCarbohydrate Recognition

This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Phytochemicals as Lead Compounds for New Drug Discovery

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  • Author : Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
  • Publisher : Elsevier
  • Release : 07 September 2019
GET THIS BOOKPhytochemicals as Lead Compounds for New Drug Discovery

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This

Pharmaceutical Biotechnology

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  • Author : Oliver Kayser,Heribert Warzecha
  • Publisher : John Wiley & Sons
  • Release : 21 May 2012
GET THIS BOOKPharmaceutical Biotechnology

This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also

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  • Author : Chi-Jen Lee,Cheng-Hsiung Lu,Lucia H. Lee
  • Publisher : CRC Press
  • Release : 28 May 2003
GET THIS BOOKDevelopment and Evaluation of Drugs

Since its initial publication in 1993, Development and Evaluation of Drugs from Laboratory through Licensure to Market has been used as a textbook and reference for scientists in biomedical research, industry, and regulatory agencies. Updated and expanded, this second edition examines recent advances in scientific and regulatory approaches as well as changes in the way in which drugs are discovered, developed, and evaluated. The information provided outlines critical steps beginning from drug discovery in the laboratory to licensure and approval for

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  • Author : Iulia M. Lazar,Maria Kontoyianni,Alexandru C. Lazar
  • Publisher : Humana Press
  • Release : 15 August 2017
GET THIS BOOKProteomics for Drug Discovery

This book reflects the drug development community’s interest in proteomics methods by providing researchers with the necessary knowledge for the implementation of a number of basic experimental and bioinformatics protocols in the drug discovery research laboratory. The focus of the collection is on select protocols and methodologies that address the analysis of post-translational modifications, targeted protein quantification, protein-protein, protein-lipid, or protein-ATP interactions, in silico lead identification, protein arrays, tissue and cell extract preparation, labeling, chemoproteomics, and drug efficacy assessment.

Drug Discovery and Development, Volume 2

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  • Author : Mukund S. Chorghade
  • Publisher : John Wiley & Sons
  • Release : 16 February 2007
GET THIS BOOKDrug Discovery and Development, Volume 2

From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview