Carbonic Anhydrases as Biocatalysts

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

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  • Author : Claudiu T Supuran
  • Publisher : Elsevier
  • Pages : 398 pages
  • ISBN : 0444632638
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCarbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts
  • Author : Claudiu T Supuran,Giuseppina De Simone
  • Publisher : Elsevier
  • Release : 14 January 2015
GET THIS BOOKCarbonic Anhydrases as Biocatalysts

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their

Carbonic Anhydrases

Carbonic Anhydrases
  • Author : Claudiu Supuran,Alessio Nocentini
  • Publisher : Academic Press
  • Release : 17 July 2019
GET THIS BOOKCarbonic Anhydrases

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors

Carbonic Anhydrases

Carbonic Anhydrases
  • Author : Claudiu Supuran,Alessio Nocentini
  • Publisher : Academic Press
  • Release : 17 July 2019
GET THIS BOOKCarbonic Anhydrases

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis
  • Author : Peter Grunwald
  • Publisher : CRC Press
  • Release : 27 June 2019
GET THIS BOOKPharmaceutical Biocatalysis

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/

Biocatalysis

Biocatalysis
  • Author : Gonzalo de Gonzalo,Pablo Domínguez de María
  • Publisher : Royal Society of Chemistry
  • Release : 02 November 2017
GET THIS BOOKBiocatalysis

Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by

Carbonic Anhydrases and Metabolism

Carbonic Anhydrases and Metabolism
  • Author : Claudiu T. Supuran
  • Publisher : MDPI
  • Release : 08 April 2019
GET THIS BOOKCarbonic Anhydrases and Metabolism

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient

The Carbonic Anhydrases

The Carbonic Anhydrases
  • Author : W.R. Chegwidden,N.D. Carter,Y.H. Edwards
  • Publisher : Birkhäuser
  • Release : 11 November 2013
GET THIS BOOKThe Carbonic Anhydrases

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene

Chemo-Biological Systems for CO2 Utilization

Chemo-Biological Systems for CO2 Utilization
  • Author : Ashok Kumar,Swati Sharma
  • Publisher : CRC Press
  • Release : 21 September 2020
GET THIS BOOKChemo-Biological Systems for CO2 Utilization

Chemo-Biological Systems for CO2 Utilization describes the most recent advanced tools and techniques for carbon dioxide capture and its utilization. It discusses and compares the advantages of different systems and aids researchers and industrialists in understanding energy generation in the form of biofuels, bioelectricity, or biogas using chemicals; nanomaterials; and microbial, enzymatic, and chemo-enzymatic-integrated systems. It describes the importance and utilization of CO2 in living systems, and provides an overview of the various fundamental methods, policies, and techniques involved in

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
  • Author : Susan C. Frost,Robert McKenna
  • Publisher : Springer Science & Business Media
  • Release : 22 October 2013
GET THIS BOOKCarbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic

Carbonic Anhydrase

Carbonic Anhydrase
  • Author : Claudiu T. Supuran,Andrea Scozzafava,Janet Conway
  • Publisher : CRC Press
  • Release : 27 May 2004
GET THIS BOOKCarbonic Anhydrase

Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in

Industrial Biocatalysis

Industrial Biocatalysis
  • Author : Peter Grunwald
  • Publisher : CRC Press
  • Release : 11 December 2014
GET THIS BOOKIndustrial Biocatalysis

Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the

Enzyme Functionality

Enzyme Functionality
  • Author : Allan Svendsen
  • Publisher : CRC Press
  • Release : 28 October 2003
GET THIS BOOKEnzyme Functionality

Enzyme Functionality serves as a conduit for trailblazing research in enzyme engineering-relating current understanding of sequence families, the new notion of enzyme structure classes, and modern methods in protein engineering, design, and directed evolution to accelerate the development of novel enzyme functionalities. This reference gathers the diverse perspectives of nearly 80 scientists from around the globe and surveys all leading rational and random approaches to the artificial evolution of enzymes. Citing more than 1500 notable works, it outlines assays for enzyme activity,

Drug Design of Zinc-Enzyme Inhibitors

Drug Design of Zinc-Enzyme Inhibitors
  • Author : Claudiu T. Supuran,Jean-Yves Winum
  • Publisher : John Wiley & Sons
  • Release : 22 October 2009
GET THIS BOOKDrug Design of Zinc-Enzyme Inhibitors

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug

Microorganisms in Environmental Management

Microorganisms in Environmental Management
  • Author : T. Satyanarayana,Bhavdish Narain Johri,Anil Prakash
  • Publisher : Springer Science & Business Media
  • Release : 02 January 2012
GET THIS BOOKMicroorganisms in Environmental Management

Microbes and their biosynthetic capabilities have been invaluable in finding solutions for several intractable problems mankind has encountered in maintaining the quality of the environment. They have, for example, been used to positive effect in human and animal health, genetic engineering, environmental protection, and municipal and industrial waste treatment. Microorganisms have enabled feasible and cost-effective responses which would have been impossible via straightforward chemical or physical engineering methods. Microbial technologies have of late been applied to a range of environmental

Physiological and Biotechnological Aspects of Extremophiles

Physiological and Biotechnological Aspects of Extremophiles
  • Author : Richa Salwan,Vivek Sharma
  • Publisher : Academic Press
  • Release : 04 June 2020
GET THIS BOOKPhysiological and Biotechnological Aspects of Extremophiles

Physiological and Biotechnological Aspects of Extremophiles highlights the current and topical areas of research in this rapidly growing field. Expert authors from around the world provide the latest insights into the mechanisms of these fascinating organisms use to survive. The vast majority of extremophiles are microbes which include archaea, bacteria and some eukaryotes. These microbes live under chemical and physical extremes that are usually lethal to cellular molecules, yet they manage to survive and even thrive. Extremophiles have important practical