The Carbonic Anhydrases

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...

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  • Author : W.R. Chegwidden
  • Publisher : Birkhäuser
  • Pages : 619 pages
  • ISBN : 303488446X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKThe Carbonic Anhydrases

The Carbonic Anhydrases

The Carbonic Anhydrases
  • Author : W.R. Chegwidden,N.D. Carter,Y.H. Edwards
  • Publisher : Birkhäuser
  • Release : 11 November 2013
GET THIS BOOKThe Carbonic Anhydrases

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene

Carbonic Anhydrases As Biocatalysts

Carbonic Anhydrases As Biocatalysts
  • Author : Claudiu T. Supuran,Giuseppina De Simone
  • Publisher : Elsevier
  • Release : 08 January 2015
GET THIS BOOKCarbonic Anhydrases As Biocatalysts

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their

Carbonic Anhydrases

Carbonic Anhydrases
  • Author : Claudiu Supuran,Alessio Nocentini
  • Publisher : Academic Press
  • Release : 17 July 2019
GET THIS BOOKCarbonic Anhydrases

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors

The Carbonic Anhydrases

The Carbonic Anhydrases
  • Author : N.D. Carter,S.J. Dodgson,G. Gros,R.E. Tashian
  • Publisher : Springer Science & Business Media
  • Release : 29 June 2013
GET THIS BOOKThe Carbonic Anhydrases

As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
  • Author : Susan C. Frost,Robert McKenna
  • Publisher : Springer Science & Business Media
  • Release : 22 October 2013
GET THIS BOOKCarbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic

Carbonic Anhydrase

Carbonic Anhydrase
  • Author : Claudiu T. Supuran,Andrea Scozzafava,Janet Conway
  • Publisher : CRC Press
  • Release : 27 May 2004
GET THIS BOOKCarbonic Anhydrase

Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in

Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts
  • Author : Claudiu T Supuran,Giuseppina De Simone
  • Publisher : Elsevier
  • Release : 14 January 2015
GET THIS BOOKCarbonic Anhydrases as Biocatalysts

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their

Carbonic Anhydrases and Metabolism

Carbonic Anhydrases and Metabolism
  • Author : Claudiu T. Supuran
  • Publisher : MDPI
  • Release : 08 April 2019
GET THIS BOOKCarbonic Anhydrases and Metabolism

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient

The Carbonic Anhydrases

The Carbonic Anhydrases
  • Author : N.D. Carter,S.J. Dodgson,G. Gros,R.E. Tashian
  • Publisher : Springer
  • Release : 27 October 2013
GET THIS BOOKThe Carbonic Anhydrases

As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant

Carbonic Anhydrase

Carbonic Anhydrase
  • Author : Francesco Botrè,Gerolf Gros,Bayard T. Storey
  • Publisher : Unknown Publisher
  • Release : 24 July 1991
GET THIS BOOKCarbonic Anhydrase

Covers almost every aspect, from structure-function relationships and genetics to present biological and clinical implications. Topics include: Biochemistry, structure and mechanism; Genetics and molecular biology of isoenzymes; Secretory systems; Metabolism and hormonal control; Respiration and bone.