Human Genome Editing

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Produk Detail:

  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Pages : 328 pages
  • ISBN : 0309452880
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKHuman Genome Editing

Human Genome Editing

Human Genome Editing
  • Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
  • Publisher : National Academies Press
  • Release : 13 August 2017
GET THIS BOOKHuman Genome Editing

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are

Cardiovascular Diseases

Cardiovascular Diseases
  • Author : Nikolaos Papageorgiou
  • Publisher : Academic Press
  • Release : 05 August 2016
GET THIS BOOKCardiovascular Diseases

Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction covers the special heritability characteristics and identifying genetic and environmental contributions to cardiovascular health. This important reference provides an overview of the genetic basis of cardiovascular disease and its risk factors. Included are important topics, ranging from lifestyle choices, risk factors, and exposure, to pollutants and chemicals. Also covered are the influences of Mendelian traits and familial aggregation and the interactions and interrelationships between genetics and environmental factors which, when compared,

Cardiovascular Genomics

Cardiovascular Genomics
  • Author : Mohan K. Raizada,Julian F. R. Paton,Michael J. Katovich,Sergey Kasparov
  • Publisher : Springer Science & Business Media
  • Release : 24 February 2008
GET THIS BOOKCardiovascular Genomics

Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular

Cardiac Gene Therapy

Cardiac Gene Therapy
  • Author : Kiyotake Ishikawa
  • Publisher : Humana Press
  • Release : 02 December 2016
GET THIS BOOKCardiac Gene Therapy

This detailed book provides methodological information on cardiac gene delivery, from classic to state-of-the-art technologies and techniques. Efficient, cardiac-specific, and safe vectors, as well as refined vector delivery methods, are key for successful cardiac gene transfer and eventually for improving patients’ outcomes. Newer vectors and more efficient vector delivery methods have the potential to dramatically improve gene transduction efficacy, while novel gene manipulation techniques enforce the therapeutic power and broaden disease targets. Written for the highly successful Methods in Molecular

Characterization of Cardiac Actin Gene Editing in Zebrafish Using CRISPR-Cas9 Technology

Characterization of Cardiac Actin Gene Editing in Zebrafish Using CRISPR-Cas9 Technology
  • Author : Love Sandhu
  • Publisher : Unknown Publisher
  • Release : 03 August 2021
GET THIS BOOKCharacterization of Cardiac Actin Gene Editing in Zebrafish Using CRISPR-Cas9 Technology

Cardiomyopathy is a common cause of heart failure. Two prevalent forms of cardiomyopathy are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), characterized by changes to the myocardium. The development of HCM and DCM has been associated with mutations found in genes encoding muscle proteins, including cardiac actin (ACTC1). My research focused on the development of zebrafish as an in vivo model to study the underlying molecular mechanisms leading to cardiomyopathy development. Three zfactc genes have been identified through literature and

Precision Medicine for Investigators, Practitioners and Providers

Precision Medicine for Investigators, Practitioners and Providers
  • Author : Joel Faintuch,Salomao Faintuch
  • Publisher : Academic Press
  • Release : 16 November 2019
GET THIS BOOKPrecision Medicine for Investigators, Practitioners and Providers

Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number

Translational Cardiometabolic Genomic Medicine

Translational Cardiometabolic Genomic Medicine
  • Author : Annabelle Rodriguez-Oquendo
  • Publisher : Academic Press
  • Release : 07 September 2015
GET THIS BOOKTranslational Cardiometabolic Genomic Medicine

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that

Regenerating the Heart

Regenerating the Heart
  • Author : Ira S. Cohen,Glenn R. Gaudette
  • Publisher : Springer Science & Business Media
  • Release : 23 March 2011
GET THIS BOOKRegenerating the Heart

Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From

Patient-Specific Induced Pluripotent Stem Cell Models

Patient-Specific Induced Pluripotent Stem Cell Models
  • Author : Andras Nagy,Kursad Turksen
  • Publisher : Humana Press
  • Release : 08 November 2015
GET THIS BOOKPatient-Specific Induced Pluripotent Stem Cell Models

This volume captures the rapid developments in the field of induced pluripotent stem (iPS) cells, which have provided novel opportunities and approaches both for better understanding a number of human diseases and for developing new platforms for drug development and screening for such diseases. Specifically, representative protocols on various disease models have been collected from labs around the world. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary

Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 08 April 2020
GET THIS BOOKGenome Plasticity in Health and Disease

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors,

Genome Editing

Genome Editing
  • Author : Kursad Turksen
  • Publisher : Springer
  • Release : 09 August 2016
GET THIS BOOKGenome Editing

This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of

Longevity Genes

Longevity Genes
  • Author : Gil Atzmon, PhD
  • Publisher : Springer
  • Release : 27 April 2015
GET THIS BOOKLongevity Genes

The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular

Gene Editing

Gene Editing
  • Author : Yuan-Chuan Chen,Shiu-Jau Chen
  • Publisher : BoD – Books on Demand
  • Release : 29 May 2019
GET THIS BOOKGene Editing

Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple