Cell Surface GRP78 a New Paradigm in Signal Transduction Biology

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease Provides four-color illustrations that facilitate the narrative

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  • Author : Salvatore V. Pizzo
  • Publisher : Academic Press
  • Pages : 144 pages
  • ISBN : 0128123524
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCell Surface GRP78 a New Paradigm in Signal Transduction Biology

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
  • Author : Salvatore V. Pizzo
  • Publisher : Academic Press
  • Release : 20 March 2018
GET THIS BOOKCell Surface GRP78, a New Paradigm in Signal Transduction Biology

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies
  • Author : Ramasamy Paulmurugan,Tarik F. Massoud
  • Publisher : Academic Press
  • Release : 25 June 2021
GET THIS BOOKGlioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists,

Antibody Engineering

Antibody Engineering
  • Author : Roland E. Kontermann,Stefan Dübel
  • Publisher : Springer Science & Business Media
  • Release : 29 June 2013
GET THIS BOOKAntibody Engineering

Interest in recombinant antibody technologies has rapidly increased because of its wide range of possible applications in therapy, diagnosis, and especially, cancer treatment. The possibility of generating human antibodies that are not accessible by conventional polyclonal or monoclonal approaches has facilitated the development of antibody engineering technologies. This manual presents a comprehensive collection of detailed step-by-step protocols, provided by experts. The text covers all basic methods needed in antibody engineering as well as recently developed and emerging technologies.

Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
  • Author : Deric L. Wheeler,Yosef Yarden
  • Publisher : Springer
  • Release : 26 November 2014
GET THIS BOOKReceptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be able to conduct fundamental research or to attempt to develop pharmacological agents able to enhance or intercept them, it is essential first to understand

Mechanisms of Insulin Action

Mechanisms of Insulin Action
  • Author : Alan R. Saltiel,Jeffrey E. Pessin
  • Publisher : Springer Science & Business Media
  • Release : 05 October 2007
GET THIS BOOKMechanisms of Insulin Action

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

Activins and Inhibins

Activins and Inhibins
  • Author : Gerald Litwack
  • Publisher : Academic Press
  • Release : 03 August 2021
GET THIS BOOKActivins and Inhibins

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and

Calcium Signaling

Calcium Signaling
  • Author : Md. Shahidul Islam
  • Publisher : Springer Nature
  • Release : 23 October 2019
GET THIS BOOKCalcium Signaling

This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future

Tissue-Specific Vascular Endothelial Signals and Vector Targeting

Tissue-Specific Vascular Endothelial Signals and Vector Targeting
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 27 September 2010
GET THIS BOOKTissue-Specific Vascular Endothelial Signals and Vector Targeting

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Includes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, providing researchers an overview and synthesis of the latest findings in the area Presents up-to-date research from leaders in the field

Extracellular Matrix Assembly and Structure

Extracellular Matrix Assembly and Structure
  • Author : Peter D. Yurchenco
  • Publisher : Academic Press
  • Release : 22 October 2013
GET THIS BOOKExtracellular Matrix Assembly and Structure

The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and

Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology
  • Author : Sadegh Babashah
  • Publisher : Springer
  • Release : 12 November 2015
GET THIS BOOKCancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the

Trafficking Inside Cells

Trafficking Inside Cells
  • Author : Nava Segev
  • Publisher : Springer Science & Business Media
  • Release : 30 May 2010
GET THIS BOOKTrafficking Inside Cells

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles
  • Author : H.J. Forman,J.M. Fukuto,Martine Torres,M. Torres
  • Publisher : Springer Science & Business Media
  • Release : 31 March 2003
GET THIS BOOKSignal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown,

Myelin

Myelin
  • Author : Kazunori Sango,Junji Yamauchi,Toru Ogata,Keiichiro Susuki
  • Publisher : Springer
  • Release : 06 December 2019
GET THIS BOOKMyelin

This book presents the latest exciting advances in understanding of the structure and function of myelin in the central and peripheral nervous systems under normal and pathological conditions. Readers will find state of the art information from the perspectives of both basic neuroscience and clinical neurology and neuropathology. Detailed attention is paid to the findings and implications of recent research on the myelin-forming glial cells such as oligodendrocytes and Schwann cells. The discussion of myelin pathology encompasses a wide range