Cell Surface GRP78 a New Paradigm in Signal Transduction Biology

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease Provides four-color illustrations that facilitate the narrative

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  • Author : Salvatore V. Pizzo
  • Publisher : Academic Press
  • Pages : 144 pages
  • ISBN : 0128123524
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCell Surface GRP78 a New Paradigm in Signal Transduction Biology

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
  • Author : Salvatore V. Pizzo
  • Publisher : Academic Press
  • Release : 20 March 2018
GET THIS BOOKCell Surface GRP78, a New Paradigm in Signal Transduction Biology

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression

Extracellular Matrix Biomineralization of Dental Tissue Structures

Extracellular Matrix Biomineralization of Dental Tissue Structures
  • Author : Michel Goldberg,Pamela Den Besten
  • Publisher : Springer Nature
  • Release : 30 September 2021
GET THIS BOOKExtracellular Matrix Biomineralization of Dental Tissue Structures

This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs). The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies
  • Author : Ramasamy Paulmurugan,Tarik F. Massoud
  • Publisher : Academic Press
  • Release : 25 June 2021
GET THIS BOOKGlioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists,

Mechanisms of Insulin Action

Mechanisms of Insulin Action
  • Author : Alan R. Saltiel,Jeffrey E. Pessin
  • Publisher : Springer Science & Business Media
  • Release : 05 October 2007
GET THIS BOOKMechanisms of Insulin Action

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

PAMP Signals in Plant Innate Immunity

PAMP Signals in Plant Innate Immunity
  • Author : P. Vidhyasekaran
  • Publisher : Springer Science & Business Media
  • Release : 30 October 2013
GET THIS BOOKPAMP Signals in Plant Innate Immunity

Plant innate immunity is a potential surveillance system of plants and is the first line of defense against invading pathogens. The immune system is a sleeping system in unstressed healthy plants and is activated on perception of the pathogen-associated molecular patterns (PAMP; the pathogen’s signature) of invading pathogens. The PAMP alarm/danger signals are perceived by plant pattern-recognition receptors (PRRs). The plant immune system uses several second messengers to encode information generated by the PAMPs and deliver the information

Protein Degradation

Protein Degradation
  • Author : R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner
  • Publisher : Wiley-VCH
  • Release : 15 April 2005
GET THIS BOOKProtein Degradation

The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize

Trafficking Inside Cells

Trafficking Inside Cells
  • Author : Nava Segev
  • Publisher : Springer Science & Business Media
  • Release : 30 May 2010
GET THIS BOOKTrafficking Inside Cells

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Cell Reprogramming for Immunotherapy

Cell Reprogramming for Immunotherapy
  • Author : Samuel G. Katz,Peter M. Rabinovich
  • Publisher : Humana
  • Release : 28 November 2019
GET THIS BOOKCell Reprogramming for Immunotherapy

This volume details key protocols for developing strategies in immunotherapy. Chapters guide the readers through protocols related to various DNA, RNA and protein methods to reprogram the immune system, immune cells, analyzing the effect of the reprogrammed cells, and key methods to consider and analyze patients enrolled in clinical trials with novel immunotherapy regimens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step,

Current Research Topics in Plant Virology

Current Research Topics in Plant Virology
  • Author : Aiming Wang,Xueping Zhou
  • Publisher : Springer
  • Release : 31 May 2018
GET THIS BOOKCurrent Research Topics in Plant Virology

Topics covered in this book include RNA silencing and its suppression in plant virus infection, virus replication mechanisms, the association of cellular membranes with virus replication and movement, plant genetic resistance to viruses, viral cell-to-cell spread, long distance movement in plants, virus induced ER stress, virus diversity and evolution, virus-vector interactions, cross protection, geminiviruses, negative strand RNA viruses, viroids, and the diagnosis of plant viral diseases using next generation sequencing. This book was anticipated to help plant pathologists, scholars, professors,

Damage-Associated Molecular Patterns in Human Diseases

Damage-Associated Molecular Patterns in Human Diseases
  • Author : Walter Gottlieb Land
  • Publisher : Springer
  • Release : 09 October 2018
GET THIS BOOKDamage-Associated Molecular Patterns in Human Diseases

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and

The Unfolded Protein Response and Cellular Stress

The Unfolded Protein Response and Cellular Stress
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 09 August 2022
GET THIS BOOKThe Unfolded Protein Response and Cellular Stress

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation The authors explain how these methods are able to provide important

Molecular Biology of the Neuron

Molecular Biology of the Neuron
  • Author : R. W. Davies,Brian J. Morris
  • Publisher : OUP Oxford
  • Release : 08 April 2004
GET THIS BOOKMolecular Biology of the Neuron

Nerve cells - neurons - are arguably the most complex of all cells. From the action of these cells comes movement, thought and consciousness. It is a challenging task to understand what molecules direct the various diverse aspects of their function. This has produced an ever-increasing amount of molecular information about neurons, and only in Molecular Biology of the Neuron can a large part of this information be found in one source. In this book, a non-specialist can learn about

Oncothermia: Principles and Practices

Oncothermia: Principles and Practices
  • Author : Andras Szasz,Nora Szasz,Oliver Szasz
  • Publisher : Springer Science & Business Media
  • Release : 23 November 2010
GET THIS BOOKOncothermia: Principles and Practices

Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of

Cyclin Dependent Kinase (CDK) Inhibitors

Cyclin Dependent Kinase (CDK) Inhibitors
  • Author : Peter K. Vogt,Stephen I. Reed
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKCyclin Dependent Kinase (CDK) Inhibitors

More than 10 years ago, the discovery of cyclin-dependent ki nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led