Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

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  • Author : Anonim
  • Publisher : Academic Press
  • Pages : 226 pages
  • ISBN : 012816574X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 30 July 2019
GET THIS BOOKCellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic

The Mouse in Animal Genetics and Breeding Research

The Mouse in Animal Genetics and Breeding Research
  • Author : Eugene J. Eisen
  • Publisher : World Scientific
  • Release : 15 August 2022
GET THIS BOOKThe Mouse in Animal Genetics and Breeding Research

The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
  • Publisher : National Academies Press
  • Release : 21 December 2000
GET THIS BOOKScientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances,

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders,

Advances in Animal Genomics

Advances in Animal Genomics
  • Author : Sukanta Mondal,Ram Lakhan Singh
  • Publisher : Academic Press
  • Release : 25 November 2020
GET THIS BOOKAdvances in Animal Genomics

Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release : 16 April 2019
GET THIS BOOKAnimal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized

Animal Biotechnology

Animal Biotechnology
  • Author : Ashish S. Verma,Anchal Singh
  • Publisher : Academic Press
  • Release : 11 June 2020
GET THIS BOOKAnimal Biotechnology

Animal Biotechnology: Models in Discovery and Translation, Second Edition, provides a helpful guide to anyone seeking a thorough review of animal biotechnology and its application to human disease and welfare. This updated edition covers vital fundamentals, including animal cell cultures, genome sequencing analysis, epigenetics and animal models, gene expression, and ethics and safety concerns, along with in-depth examples of implications for human health and prospects for the future. New chapters cover animal biotechnology as applied to various disease types and

Gene Discovery for Disease Models

Gene Discovery for Disease Models
  • Author : Weikuan Gu,Yongjun Wang
  • Publisher : John Wiley & Sons
  • Release : 03 March 2011
GET THIS BOOKGene Discovery for Disease Models

This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that “The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from

Use of Laboratory Animals in Biomedical and Behavioral Research

Use of Laboratory Animals in Biomedical and Behavioral Research
  • Author : National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research
  • Publisher : National Academies Press
  • Release : 01 February 1988
GET THIS BOOKUse of Laboratory Animals in Biomedical and Behavioral Research

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of

Animal Models of Speech and Language Disorders

Animal Models of Speech and Language Disorders
  • Author : Santosh A. Helekar
  • Publisher : Springer Science & Business Media
  • Release : 17 October 2013
GET THIS BOOKAnimal Models of Speech and Language Disorders

Basic research over the last decade or two has uncovered similarities between speech, especially its sensori-motor aspects, and vocal communication in several non-human species. The most comprehensive studies so far have been conducted in songbirds. Songbirds offer us a model system to study the interactions between developmental or genetic predispositions and tutor-dependent influences, on the learning of vocal communication. Songbird research has elucidated cellular and molecular mechanisms underlying learning and production of vocal patterns, perception of vocal sounds, vocal motor

Mapping and Sequencing the Human Genome

Mapping and Sequencing the Human Genome
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
  • Publisher : National Academies Press
  • Release : 01 January 1988
GET THIS BOOKMapping and Sequencing the Human Genome

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a

Molecular and Functional Models in Neuropsychiatry

Molecular and Functional Models in Neuropsychiatry
  • Author : Jim J. Hagan
  • Publisher : Springer Science & Business Media
  • Release : 02 April 2011
GET THIS BOOKMolecular and Functional Models in Neuropsychiatry

The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive

Heritable Human Genome Editing

Heritable Human Genome Editing
  • Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
  • Publisher : National Academies Press
  • Release : 16 January 2021
GET THIS BOOKHeritable Human Genome Editing

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing

Adenovirus

Adenovirus
  • Author : Miguel Chillón,Assumpció Bosch
  • Publisher : Humana Press
  • Release : 29 October 2013
GET THIS BOOKAdenovirus

Reflecting the development of powerful new tools and high-throughput methods to analyze adenoviral particles and their interactions with host cells, the third edition of Adenovirus Methods and Protocols calls upon experts in the field to convey advances in molecular biology, genomics and proteomics, imaging, and bioinformatics. Beginning with cryo-electron microscopy, atomic force microscopy, and mass spectrometry for a high resolution image and characterization of the virion, this detailed book then continues with capsid modifications and viral-like particles as promising alternatives