Cellular Senescence in Disease

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities Provides a thorough introduction to Cellular Senescence Covers all major pathologies for which cellular senescence has shown evidence of involvement Focuses on possible therapeutic pathways Edited and authored by worldwide experts

Produk Detail:

  • Author : Manuel Serrano
  • Publisher : Academic Press
  • Pages : 350 pages
  • ISBN : 9780128225141
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCellular Senescence in Disease

Cellular Senescence in Disease

Cellular Senescence in Disease
  • Author : Manuel Serrano,Daniel Munos
  • Publisher : Academic Press
  • Release : 15 September 2021
GET THIS BOOKCellular Senescence in Disease

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration
  • Author : Phillip K. Peterson,Michal Toborek
  • Publisher : Springer
  • Release : 08 July 2014
GET THIS BOOKNeuroinflammation and Neurodegeneration

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the

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  • Author : Marcelo Larramendy
  • Publisher : BoD – Books on Demand
  • Release : 23 November 2016
GET THIS BOOKTelomere

This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other

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Cellular Ageing and Replicative Senescence
  • Author : Suresh I.S. Rattan,Leonard Hayflick
  • Publisher : Springer
  • Release : 09 May 2016
GET THIS BOOKCellular Ageing and Replicative Senescence

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to

Molecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging
  • Author : Marco Malavolta,Eugenio Mocchegiani
  • Publisher : Academic Press
  • Release : 15 April 2016
GET THIS BOOKMolecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and

Senolytics in Disease, Ageing and Longevity

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  • Author : Daniel Muñoz-Espin,Marco Demaria
  • Publisher : Springer
  • Release : 12 May 2021
GET THIS BOOKSenolytics in Disease, Ageing and Longevity

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the

Aging

Aging
  • Author : L. Robert,T. Fulop
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 16 May 2014
GET THIS BOOKAging

Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important

Senolytics in Disease, Ageing and Longevity

Senolytics in Disease, Ageing and Longevity
  • Author : Daniel Muñoz-Espin,Marco Demaria
  • Publisher : Springer Nature
  • Release : 27 April 2020
GET THIS BOOKSenolytics in Disease, Ageing and Longevity

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the

Protein Expression in Down Syndrome Brain

Protein Expression in Down Syndrome Brain
  • Author : G. Lubec
  • Publisher : Springer Science & Business Media
  • Release : 15 October 2001
GET THIS BOOKProtein Expression in Down Syndrome Brain

When we worked on Down Syndrome brain in the past we have been focus ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced proteomics to identify and quantify brain protein expression. We considered evaluation of brain protein expression in Down Syndrome brain by and by more important than gene hunting at the nucleic acid level realiz ing the long unpredictable way

Frailty and Cardiovascular Diseases

Frailty and Cardiovascular Diseases
  • Author : Nicola Veronese
  • Publisher : Springer Nature
  • Release : 01 January 2020
GET THIS BOOKFrailty and Cardiovascular Diseases

This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part

Handbook on Immunosenescence

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  • Author : Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
  • Publisher : Springer Science & Business Media
  • Release : 27 February 2009
GET THIS BOOKHandbook on Immunosenescence

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

Ageless

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  • Author : Andrew Steele
  • Publisher : Doubleday
  • Release : 23 March 2021
GET THIS BOOKAgeless

A startling chronicle by a brilliant young scientist takes us onto the frontiers of the science of aging, and reveals how close we are to an astonishing extension of our life spans and a vastly improved quality of life in our later years. Aging--not cancer, not heart disease--is the true underlying cause of most human death and suffering. We accept as inevitable that as we advance in years our bodies and minds begin to deteriorate and that we are ever

Tumor Dormancy, Quiescence, and Senescence, Volume 2

Tumor Dormancy, Quiescence, and Senescence, Volume 2
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release : 29 November 2013
GET THIS BOOKTumor Dormancy, Quiescence, and Senescence, Volume 2

In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that

Telomeres and Telomerase in Aging, Disease, and Cancer

Telomeres and Telomerase in Aging, Disease, and Cancer
  • Author : K. Lenhard Rudolph
  • Publisher : Springer Science & Business Media
  • Release : 07 November 2007
GET THIS BOOKTelomeres and Telomerase in Aging, Disease, and Cancer

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering
  • Author : Rakesh Sharma
  • Publisher : BoD – Books on Demand
  • Release : 02 May 2018
GET THIS BOOKStem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters