Cellular Senescence in Disease

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities. Provides a thorough introduction to Cellular Senescence Covers all major pathologies for which cellular senescence has shown evidence of involvement Focuses on possible therapeutic pathways Edited and authored by worldwide experts

Produk Detail:

  • Author : Manuel Serrano
  • Publisher : Academic Press
  • Pages : 472 pages
  • ISBN : 0128225157
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCellular Senescence in Disease

Cellular Senescence in Disease

Cellular Senescence in Disease
  • Author : Manuel Serrano,Daniel Munoz-Espin
  • Publisher : Academic Press
  • Release : 27 November 2021
GET THIS BOOKCellular Senescence in Disease

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence
  • Author : Suresh I.S. Rattan,Leonard Hayflick
  • Publisher : Springer
  • Release : 09 May 2016
GET THIS BOOKCellular Ageing and Replicative Senescence

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to

Senolytics in Disease, Ageing and Longevity

Senolytics in Disease, Ageing and Longevity
  • Author : Daniel Muñoz-Espin,Marco Demaria
  • Publisher : Springer Nature
  • Release : 27 April 2020
GET THIS BOOKSenolytics in Disease, Ageing and Longevity

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the

Endothelial Dysfunction

Endothelial Dysfunction
  • Author : Helena Lenasi
  • Publisher : BoD – Books on Demand
  • Release : 24 October 2018
GET THIS BOOKEndothelial Dysfunction

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in

Cellular Senescence in Health, Disease and Aging

Cellular Senescence in Health, Disease and Aging
  • Author : Markus Riessland
  • Publisher : Mdpi AG
  • Release : 08 November 2021
GET THIS BOOKCellular Senescence in Health, Disease and Aging

Dear Colleagues, When Hayflick and Moorhead coined the term "cellular senescence" (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial roles for CS have been identified, such as embryonic development and wound healing. The senescence associated secretory phenotype (SASP) activated in most senescent cells (SC) signals to the immune system "come here and remove me". In organisms with young and functional immune systems,

Telomere

Telomere
  • Author : Marcelo Larramendy
  • Publisher : BoD – Books on Demand
  • Release : 23 November 2016
GET THIS BOOKTelomere

This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 25 August 2020
GET THIS BOOKMetabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes

Frailty and Cardiovascular Diseases

Frailty and Cardiovascular Diseases
  • Author : Nicola Veronese
  • Publisher : Springer Nature
  • Release : 01 January 2020
GET THIS BOOKFrailty and Cardiovascular Diseases

This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part

Autophagy and Senescence in Cancer Therapy

Autophagy and Senescence in Cancer Therapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 13 April 2021
GET THIS BOOKAutophagy and Senescence in Cancer Therapy

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for

Innovative Medicine

Innovative Medicine
  • Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
  • Publisher : Springer
  • Release : 13 October 2015
GET THIS BOOKInnovative Medicine

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps

Handbook on Immunosenescence

Handbook on Immunosenescence
  • Author : Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
  • Publisher : Springer Science & Business Media
  • Release : 27 February 2009
GET THIS BOOKHandbook on Immunosenescence

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

The Evolution of Senescence in the Tree of Life

The Evolution of Senescence in the Tree of Life
  • Author : Richard P. Shefferson,Owen R. Jones,Roberto Salguero-Gómez
  • Publisher : Cambridge University Press
  • Release : 23 February 2017
GET THIS BOOKThe Evolution of Senescence in the Tree of Life

The existing theories on the evolution of senescence assume that senescence is inevitable in all organisms. However, recent studies have shown that this is not necessarily true. A better understanding of senescence and its underlying mechanisms could have far-reaching consequences for conservation and eco-evolutionary research. This book is the first to offer interdisciplinary perspectives on the evolution of senescence in many species, setting the stage for further developments. It brings together new insights from a wide range of scientific fields

Hepatocellular Carcinoma

Hepatocellular Carcinoma
  • Author : Costin Teodor Streba,Cristin Constantin Vere,Ion Rogoveanu
  • Publisher : BoD – Books on Demand
  • Release : 28 November 2018
GET THIS BOOKHepatocellular Carcinoma

Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated,