Chemical Biology of the Genome

Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery

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  • Author : Siddhartha Roy
  • Publisher : Academic Press
  • Pages : 350 pages
  • ISBN : 0128176458
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKChemical Biology of the Genome

Chemical Biology of the Genome

Chemical Biology of the Genome
  • Author : Siddhartha Roy,Tapas K. Kundu
  • Publisher : Academic Press
  • Release : 28 May 2021
GET THIS BOOKChemical Biology of the Genome

Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout,

The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs
  • Author : Stefan Jurga,Jan Barciszewski
  • Publisher : Springer Nature
  • Release : 01 October 2020
GET THIS BOOKThe Chemical Biology of Long Noncoding RNAs

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A

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Chemical Biology of Natural Products
  • Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
  • Publisher : CRC Press
  • Release : 22 September 2017
GET THIS BOOKChemical Biology of Natural Products

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing

Advancing Development of Synthetic Gene Regulators

Advancing Development of Synthetic Gene Regulators
  • Author : Anandhakumar Chandran
  • Publisher : Springer
  • Release : 19 September 2017
GET THIS BOOKAdvancing Development of Synthetic Gene Regulators

This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates

Chemical Genomics

Chemical Genomics
  • Author : Haian Fu
  • Publisher : Unknown Publisher
  • Release : 01 August 2021
GET THIS BOOKChemical Genomics

Advances in chemistry, biology, and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text with contributions from experts in the field discusses evolving concepts, essential techniques, and a wide range of applications to help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes

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The Music of Life
  • Author : Denis Noble
  • Publisher : Oxford University Press
  • Release : 14 February 2008
GET THIS BOOKThe Music of Life

What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes.But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative

Mapping and Sequencing the Human Genome

Mapping and Sequencing the Human Genome
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
  • Publisher : National Academies Press
  • Release : 01 January 1988
GET THIS BOOKMapping and Sequencing the Human Genome

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a

Molecular Biology

Molecular Biology
  • Author : Nancy Lynn Craig,Rachel Green,Orna Cohen-Fix,Carol W. Greider,Gisela Storz,Cynthia Wolberger
  • Publisher : Oxford University Press
  • Release : 01 August 2021
GET THIS BOOKMolecular Biology

Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many intriguing questions remain to be answered. Itis written with several guiding themes in mind: - A focus on key principles provides a robust

Protein Targeting with Small Molecules

Protein Targeting with Small Molecules
  • Author : Hiroyuki Osada
  • Publisher : John Wiley & Sons
  • Release : 31 July 2009
GET THIS BOOKProtein Targeting with Small Molecules

Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal

Globalization, Biosecurity, and the Future of the Life Sciences

Globalization, Biosecurity, and the Future of the Life Sciences
  • Author : National Research Council,Institute of Medicine,Board on Global Health,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare Threats
  • Publisher : National Academies Press
  • Release : 07 June 2006
GET THIS BOOKGlobalization, Biosecurity, and the Future of the Life Sciences

Biomedical advances have made it possible to identify and manipulate features of living organisms in useful ways--leading to improvements in public health, agriculture, and other areas. The globalization of scientific and technical expertise also means that many scientists and other individuals around the world are generating breakthroughs in the life sciences and related technologies. The risks posed by bioterrorism and the proliferation of biological weapons capabilities have increased concern about how the rapid advances in genetic engineering and biotechnology could

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The Evolution of Molecular Biology
  • Author : Kensal Van Holde,Jordanka Zlatanova
  • Publisher : Academic Press
  • Release : 20 February 2018
GET THIS BOOKThe Evolution of Molecular Biology

The Evolution of Molecular Biology: The Search for the Secrets of Life provides the historical knowledge behind techniques founded in molecular biology, also presenting an appreciation of how, and by whom, these discoveries were made. It deals with the evolution of intellectual concepts in the context of active research in an approachable language that accommodates readers from a variety of backgrounds. Each chapter contains a prologue and epilogue to create continuity and provide a complete framework of molecular biology. This

Drug Discovery from Natural Products

Drug Discovery from Natural Products
  • Author : Olga Genilloud,Francisca Vicente
  • Publisher : Royal Society of Chemistry
  • Release : 21 August 2012
GET THIS BOOKDrug Discovery from Natural Products

This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting multiples stages of modern drug discovery from NPs that have not been included in other works. This is complemented with a series of case studies from leading experts from industry

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Structure and Function of the Bacterial Genome
  • Author : Charles J. Dorman
  • Publisher : John Wiley & Sons
  • Release : 28 April 2020
GET THIS BOOKStructure and Function of the Bacterial Genome

Presents an integrated view of the expression of bacterial genetic information, genome architecture and function, and bacterial physiology and pathogenesis This book blends information from the very latest research on bacterial chromosome and nucleoid architecture, whole-genome analysis, cell signaling, and gene expression control with well-known gene regulation paradigms from model organisms (including pathogens) to give readers a picture of how information flows from the environment to the gene, modulating its expression and influencing the competitive fitness of the microbe. Structure