Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer’s and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds Provides discipline-specific chapters that cover medicinal chemistry and clinical applications Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery

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  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Pages : 260 pages
  • ISBN : 012801959X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKChemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release : 14 January 2015
GET THIS BOOKChemical Modulators of Protein Misfolding and Neurodegenerative Disease

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer’s and other tauopathies. Properties and development status

Quality Control of Cellular Protein in Neurodegenerative Disorders

Quality Control of Cellular Protein in Neurodegenerative Disorders
  • Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
  • Publisher : IGI Global
  • Release : 14 February 2020
GET THIS BOOKQuality Control of Cellular Protein in Neurodegenerative Disorders

Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Molecular Targets in Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release : 07 October 2014
GET THIS BOOKMolecular Targets in Protein Misfolding and Neurodegenerative Disease

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads,

Advances in Protein Chemistry and Structural Biology

Advances in Protein Chemistry and Structural Biology
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 17 November 2015
GET THIS BOOKAdvances in Protein Chemistry and Structural Biology

The Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students

Using Old Solutions to New Problems

Using Old Solutions to New Problems
  • Author : Marianna Kulka
  • Publisher : BoD – Books on Demand
  • Release : 19 June 2013
GET THIS BOOKUsing Old Solutions to New Problems

The medicinal use of plants, animals and microorganisms has been a part of human evolution and likely began before recorded history. Is it possible that this knowledge can be used to create powerful new drugs and solve some of the human health problems facing us today? This book is a collection of an expert team of agronomists, chemists, biologists and policy makers who discuss some of the processes involved in developing a naturally-sourced bioactive compound into a drug therapy. These

Chemical Biology of Neurodegeneration

Chemical Biology of Neurodegeneration
  • Author : Pedro Merino
  • Publisher : John Wiley & Sons
  • Release : 18 November 2019
GET THIS BOOKChemical Biology of Neurodegeneration

Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and

Cellular Osmolytes

Cellular Osmolytes
  • Author : Laishram Rajendrakumar Singh,Tanveer Ali Dar
  • Publisher : Springer
  • Release : 16 May 2017
GET THIS BOOKCellular Osmolytes

This book provides essential information on improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. The protein folding solvent environment mainly consists of salts, small molecule compounds, metabolites, molecular chaperones and other chemical species. Therefore, subtle change in the composition of the environment will alter the protein folding process. The importance of the solvent environment in protein folding is precisely due to the

Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases

Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
  • Author : Yu Tang,Isidre Ferrer
  • Publisher : Frontiers Media SA
  • Release : 12 April 2021
GET THIS BOOKMicroglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases

Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (

Spoiled Brats

Spoiled Brats
  • Author : Simon Rich
  • Publisher : Profile Books
  • Release : 21 August 2014
GET THIS BOOKSpoiled Brats

Having skewered the problems of falling in and out of love in The Last Girlfriend on Earth, Simon Rich's next book is another subject we can all relate to: parents and their kids. From the perils of raising an actual monster in Manhattan - it's pretty hard to find teachers who really understand the talents of a five-year-old with horns and a taste for blood - to Sell Out, the story of Simon's ancestor, returned to life decades after an

Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery
  • Author : Pierfausto Seneci
  • Publisher : Elsevier
  • Release : 05 June 2018
GET THIS BOOKChemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the

The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases
  • Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
  • Publisher : Springer
  • Release : 20 September 2016
GET THIS BOOKThe Benefits of Natural Products for Neurodegenerative Diseases

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure

The Chaperonins

The Chaperonins
  • Author : Reginald John Ellis
  • Publisher : Unknown Publisher
  • Release : 12 April 1996
GET THIS BOOKThe Chaperonins

The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations. Key Features * Origins of the new view of protein folding * Prokaryotic chaperonins * Eukaryotic chaperonins * Evolution of the chaperonins * Refolding of denatured proteins * Organelle biosynthesis * Biomedical aspects

Cyclin Dependent Kinase 5 (Cdk5)

Cyclin Dependent Kinase 5 (Cdk5)
  • Author : Nancy Y. Ip,Li-Huei Tsai
  • Publisher : Springer Science & Business Media
  • Release : 28 February 2009
GET THIS BOOKCyclin Dependent Kinase 5 (Cdk5)

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation

Wiley Encyclopedia of Molecular Medicine, Volume 5

Wiley Encyclopedia of Molecular Medicine, Volume 5
  • Author : Wiley
  • Publisher : Wiley-Interscience
  • Release : 01 November 2001
GET THIS BOOKWiley Encyclopedia of Molecular Medicine, Volume 5

The field of molecular biology is revolutionizing human medicine and the applications of molecular biology to medicine are expanding. Encyclopedia of Molecular Medicine brings together those aspects of medicine that have significance at the molecular level, plus advances in molecular biology that are relevant to medicine. With over 1,700 separate primary entries, this comprehensive encyclopedia sets the standard for reference works in this rapidly expanding field. Edited by one of the most renowned names in the field of protein science, the

Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
  • Author : Peter Csermely,László Vígh
  • Publisher : Springer Science & Business Media
  • Release : 09 August 2007
GET THIS BOOKMolecular Aspects of the Stress Response: Chaperones, Membranes and Networks

This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.