Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. • Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds; • Provides discipline-specific chapters that cover medicinal chemistry and clinical applications; • Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder; • Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery.

Produk Detail:

  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Pages : 260 pages
  • ISBN : 9780128019443
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKChemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release : 12 January 2015
GET THIS BOOKChemical Modulators of Protein Misfolding and Neurodegenerative Disease

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release : 14 January 2015
GET THIS BOOKChemical Modulators of Protein Misfolding and Neurodegenerative Disease

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer’s and other tauopathies. Properties and development status

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Molecular Targets in Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release : 07 October 2014
GET THIS BOOKMolecular Targets in Protein Misfolding and Neurodegenerative Disease

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads,

Using Old Solutions to New Problems

Using Old Solutions to New Problems
  • Author : Marianna Kulka
  • Publisher : BoD – Books on Demand
  • Release : 19 June 2013
GET THIS BOOKUsing Old Solutions to New Problems

The medicinal use of plants, animals and microorganisms has been a part of human evolution and likely began before recorded history. Is it possible that this knowledge can be used to create powerful new drugs and solve some of the human health problems facing us today? This book is a collection of an expert team of agronomists, chemists, biologists and policy makers who discuss some of the processes involved in developing a naturally-sourced bioactive compound into a drug therapy. These

Quality Control of Cellular Protein in Neurodegenerative Disorders

Quality Control of Cellular Protein in Neurodegenerative Disorders
  • Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
  • Publisher : IGI Global
  • Release : 14 February 2020
GET THIS BOOKQuality Control of Cellular Protein in Neurodegenerative Disorders

Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the

Protein Misfolding Diseases

Protein Misfolding Diseases
  • Author : Marina Ramirez-Alvarado,Jeffery W. Kelly,Christopher M. Dobson
  • Publisher : John Wiley & Sons
  • Release : 01 December 2010
GET THIS BOOKProtein Misfolding Diseases

An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.

Chemical Biology of Neurodegeneration

Chemical Biology of Neurodegeneration
  • Author : Pedro Merino
  • Publisher : John Wiley & Sons
  • Release : 18 November 2019
GET THIS BOOKChemical Biology of Neurodegeneration

Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and

Protein Misfolding in Neurodegenerative Diseases

Protein Misfolding in Neurodegenerative Diseases
  • Author : Robert D. E. Sewell
  • Publisher : CRC Press
  • Release : 03 December 2007
GET THIS BOOKProtein Misfolding in Neurodegenerative Diseases

Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms

Leucine-Rich Repeat Kinase 2 (LRRK2)

Leucine-Rich Repeat Kinase 2 (LRRK2)
  • Author : Hardy J. Rideout
  • Publisher : Springer
  • Release : 28 March 2017
GET THIS BOOKLeucine-Rich Repeat Kinase 2 (LRRK2)

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It

Nanoimaging

Nanoimaging
  • Author : Beth A. Goins,William T. Phillips
  • Publisher : CRC Press
  • Release : 07 September 2011
GET THIS BOOKNanoimaging

The first resource of its kind, this book covers cutting-edge research on the use of nanoparticles for in vivo diagnostic medical imaging and therapy. It discusses a variety of nanoparticles, including quantum dots, carbon nanotubes, dendrimers, gold nanoshells, metal nanorods, micelles, liposomes, polymers, MRI iron oxide particles, and microbubbles. Examples in the book include multifunctional nanoparticles that designed for multimodality imaging and simultaneous diagnostic and therapy (theranostic) applications.

Chemical Biology of Neurodegeneration

Chemical Biology of Neurodegeneration
  • Author : Pedro Merino
  • Publisher : John Wiley & Sons
  • Release : 07 August 2019
GET THIS BOOKChemical Biology of Neurodegeneration

Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and

Protein Folding Disorders Of The Central Nervous System

Protein Folding Disorders Of The Central Nervous System
  • Author : Ghiso Jorge A,Rostagno Agueda A
  • Publisher : World Scientific
  • Release : 15 September 2017
GET THIS BOOKProtein Folding Disorders Of The Central Nervous System

This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons

Proteostasis and Chaperone Surveillance

Proteostasis and Chaperone Surveillance
  • Author : Laishram Rajendrakumar Singh,Tanveer Ali Dar,Parvaiz Ahmad
  • Publisher : Springer
  • Release : 26 November 2015
GET THIS BOOKProteostasis and Chaperone Surveillance

Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure,

Fundamentals of Neurodegeneration and Protein Misfolding Disorders

Fundamentals of Neurodegeneration and Protein Misfolding Disorders
  • Author : Martin Beckerman
  • Publisher : Springer
  • Release : 06 November 2015
GET THIS BOOKFundamentals of Neurodegeneration and Protein Misfolding Disorders

This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region.