Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the book is a practical resource for organic-medicinal chemists, biological chemists and pharmacologists involved in drug discovery. Reviews the key application of chemistry in drug discovery for both medicinal and non-medicinal chemists, clarifying and explaining the role of medicinal chemistry in supporting the modern drug discovery pipeline Shows how a wider medicinal chemistry view is essential for anyone in an integrated drug discovery project looking to reduce costs and save time Provides the critical success factors needed to successfully identify hits from both biological and chemical perspectives

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  • Author : Pierfausto Seneci
  • Publisher : Elsevier
  • Pages : 194 pages
  • ISBN : 008099928X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKChemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery
  • Author : Pierfausto Seneci
  • Publisher : Elsevier
  • Release : 05 June 2018
GET THIS BOOKChemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the

Research Methodology in Chemical Sciences

Research Methodology in Chemical Sciences
  • Author : Tanmoy Chakraborty,Lalita Ledwani
  • Publisher : CRC Press
  • Release : 03 March 2017
GET THIS BOOKResearch Methodology in Chemical Sciences

Recent Methodology in Chemical Sciences provides an eclectic survey of contemporary problems in experimental, theoretical, and applied chemistry. This book covers recent trends in research with the different domain of the chemical sciences. The chapters, written by knowledgeable researchers, provide different insights to the modern-day research in the domain of spectroscopy, plasma modification, and theoretical and computational analysis of chemical problems. It covers descriptions of experimental techniques, discussions on theoretical modeling, and much more.

Small Molecule Drug Discovery

Small Molecule Drug Discovery
  • Author : Andrea Trabocchi,Elena Lenci
  • Publisher : Elsevier
  • Release : 23 November 2019
GET THIS BOOKSmall Molecule Drug Discovery

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The

Chemical Sciences in the 20th Century

Chemical Sciences in the 20th Century
  • Author : Carsten Reinhardt
  • Publisher : John Wiley & Sons
  • Release : 26 September 2008
GET THIS BOOKChemical Sciences in the 20th Century

Chemistry in the last century was characterized by spectacular growth and advances, stimulated by revolutionary theories and experimental breakthroughs. Yet, despite this rapid development, the history of this scientific discipline has achieved only recently the status necessary to understand the effects of chemistry on the scientific and technological culture of the modern world. This book addresses the bridging of boundaries between chemistry and the other "classical" disciplines of science, physics and biology as well as the connections of chemistry to

The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry
  • Author : Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
  • Publisher : Elsevier
  • Release : 01 July 2015
GET THIS BOOKThe Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to

Chemogenomics in Drug Discovery

Chemogenomics in Drug Discovery
  • Author : Hugo Kubinyi,Gerhard Müller
  • Publisher : John Wiley & Sons
  • Release : 06 March 2006
GET THIS BOOKChemogenomics in Drug Discovery

Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery

Pharmaceutical Process Development

Pharmaceutical Process Development
  • Author : A. John Blacker,Mike T. Williams
  • Publisher : Royal Society of Chemistry
  • Release : 07 May 2021
GET THIS BOOKPharmaceutical Process Development

This book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry by informing them about the breadth of the work carried out in chemical research and development departments. It is also of great value to academics wishing to advise students on the merits of careers in chemical development over discovery.

Early Drug Development, 2 Volume Set

Early Drug Development, 2 Volume Set
  • Author : Fabrizio Giordanetto
  • Publisher : John Wiley & Sons
  • Release : 10 December 2018
GET THIS BOOKEarly Drug Development, 2 Volume Set

This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the

The Discovery and Utility of Chemical Probes in Target Discovery

The Discovery and Utility of Chemical Probes in Target Discovery
  • Author : Paul Brennan,Saleta Vazquez-Rodriguez
  • Publisher : Royal Society of Chemistry
  • Release : 25 November 2020
GET THIS BOOKThe Discovery and Utility of Chemical Probes in Target Discovery

Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new

Mass Spectrometry in Medicinal Chemistry

Mass Spectrometry in Medicinal Chemistry
  • Author : Klaus Wanner,Georg H?fner
  • Publisher : John Wiley & Sons
  • Release : 09 April 2007
GET THIS BOOKMass Spectrometry in Medicinal Chemistry

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly

Chemical Discovery and Invention in the Twentieth Century

Chemical Discovery and Invention in the Twentieth Century
  • Author : Wiliam A. Tilden
  • Publisher : Routledge
  • Release : 17 August 2018
GET THIS BOOKChemical Discovery and Invention in the Twentieth Century

First published in 1919. Tilden discusses a compilation of chemical discovery and invention to demonstrate the progress of chemistry in the early 20th century. Divided into 5 sections, chemical laboratories and the work done in them, modern discoveries and theories, modern applications of chemistry, and modern progress in organic chemistry, the author presents an overview of the subject. The final section of the book contains an account of important discoveries which find practical applications and provide new views of the constitution of

3D Printing in Chemical Sciences

3D Printing in Chemical Sciences
  • Author : Vipul Gupta,Pavel Nesterenko,Brett Paull
  • Publisher : Royal Society of Chemistry
  • Release : 20 March 2019
GET THIS BOOK3D Printing in Chemical Sciences

3D printing has rapidly established itself as an essential enabling technology within research and industrial chemistry laboratories. Since the early 2000s, when the first research papers applying this technique began to emerge, the uptake by the chemistry community has been both diverse and extraordinary, and there is little doubt that this fascinating technology will continue to have a major impact upon the chemical sciences going forward. This book provides a timely and extensive review of the reported applications of 3D