Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the book is a practical resource for organic-medicinal chemists, biological chemists and pharmacologists involved in drug discovery. Reviews the key application of chemistry in drug discovery for both medicinal and non-medicinal chemists, clarifying and explaining the role of medicinal chemistry in supporting the modern drug discovery pipeline Shows how a wider medicinal chemistry view is essential for anyone in an integrated drug discovery project looking to reduce costs and save time Provides the critical success factors needed to successfully identify hits from both biological and chemical perspectives

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  • Author : Pierfausto Seneci
  • Publisher : Elsevier
  • Pages : 194 pages
  • ISBN : 008099928X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKChemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery
  • Author : Pierfausto Seneci
  • Publisher : Elsevier
  • Release : 05 June 2018
GET THIS BOOKChemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the

Small Molecule Drug Discovery

Small Molecule Drug Discovery
  • Author : Andrea Trabocchi,Elena Lenci
  • Publisher : Elsevier
  • Release : 23 November 2019
GET THIS BOOKSmall Molecule Drug Discovery

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The

Pharmaceutical Process Development

Pharmaceutical Process Development
  • Author : John Blacker,Michael T Williams
  • Publisher : Royal Society of Chemistry
  • Release : 17 August 2011
GET THIS BOOKPharmaceutical Process Development

Pharmaceutical process research and development is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. In 15 concise chapters the book covers such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of

ADMET for Medicinal Chemists

ADMET for Medicinal Chemists
  • Author : Katya Tsaioun,Steven A. Kates
  • Publisher : John Wiley & Sons
  • Release : 15 February 2011
GET THIS BOOKADMET for Medicinal Chemists

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
  • Author : Benjamin E. Blass
  • Publisher : Academic Press
  • Release : 25 May 2021
GET THIS BOOKBasic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and

Lead Generation Approaches in Drug Discovery

Lead Generation Approaches in Drug Discovery
  • Author : Zoran Rankovic,Richard Morphy
  • Publisher : John Wiley & Sons
  • Release : 07 April 2010
GET THIS BOOKLead Generation Approaches in Drug Discovery

An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory,

High Throughput Analysis for Early Drug Discovery

High Throughput Analysis for Early Drug Discovery
  • Author : James Kyranos
  • Publisher : Elsevier
  • Release : 18 September 2004
GET THIS BOOKHigh Throughput Analysis for Early Drug Discovery

High Throughput Analysis for Early Drug Discovery offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic

Drug Discovery and Development - E-Book

Drug Discovery and Development - E-Book
  • Author : Raymond G Hill
  • Publisher : Elsevier Health Sciences
  • Release : 20 July 2012
GET THIS BOOKDrug Discovery and Development - E-Book

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories

Early Drug Development

Early Drug Development
  • Author : Fabrizio Giordanetto
  • Publisher : John Wiley & Sons
  • Release : 15 June 2018
GET THIS BOOKEarly Drug Development

This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the

Managing the Drug Discovery Process

Managing the Drug Discovery Process
  • Author : Walter Moos,Susan Miller,Stephen Munk,Barbara Munk
  • Publisher : Woodhead Publishing
  • Release : 08 November 2016
GET THIS BOOKManaging the Drug Discovery Process

Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological, and infrastructural. Since drug research can be a high-risk, high-payoff industry, it is important to researchers to effectively and

Frontiers in Chemistry: Rising Stars

Frontiers in Chemistry: Rising Stars
  • Author : Steve Suib,Huangxian Ju,Serge Cosnier,Bunsho Ohtani,John D. Wade,Gil Garnier,Nosang Vincent Myung,Luís D. Carlos,Michael Kassiou,Fan Zhang,Iwao Ojima,Pellegrino Musto,Tony D. James,Thomas S. Hofer,Sam P. De Visser
  • Publisher : Frontiers Media SA
  • Release : 17 April 2020
GET THIS BOOKFrontiers in Chemistry: Rising Stars

The Frontiers in Chemistry Editorial Office team are delighted to present the inaugural “Frontiers in Chemistry: Rising Stars” article collection, showcasing the high-quality work of internationally recognized researchers in the early stages of their independent careers. All Rising Star researchers featured within this collection were individually nominated by the Journal’s Chief Editors in recognition of their potential to influence the future directions in their respective fields. The work presented here highlights the diversity of research performed across the entire

Platform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation
  • Author : Robert A. Goodnow
  • Publisher : Academic Press
  • Release : 18 November 2017
GET THIS BOOKPlatform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique

Comprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III
  • Author : Simon Ward
  • Publisher : Academic Press
  • Release : 01 July 2017
GET THIS BOOKComprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III, Third Edition provides a contemporary and forward looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of

Chemical Sciences in the Modern World

Chemical Sciences in the Modern World
  • Author : Seymour H. Mauskopf
  • Publisher : Anniversary Collection
  • Release : 24 July 1993
GET THIS BOOKChemical Sciences in the Modern World

It would be difficult to overestimate the importance of the chemical sciences to the modern world. In the last 150 years, they have transformed our physical environment, our material culture, our manner of living, and even our persons--and they are continuing to do so in profound ways. Yet the detailed and systematic study of the history of the modern chemical sciences has been relatively late in coming. This compilation of essays by leading scholars represents the first fruits of modern historical

The Era of Artificial Intelligence, Machine Learning, and Data Science in the Pharmaceutical Industry

The Era of Artificial Intelligence, Machine Learning, and Data Science in the Pharmaceutical Industry
  • Author : Stephanie K. Ashenden
  • Publisher : Academic Press
  • Release : 07 May 2021
GET THIS BOOKThe Era of Artificial Intelligence, Machine Learning, and Data Science in the Pharmaceutical Industry

The Era of Artificial Intelligence, Machine Learning and Data Science in the Pharmaceutical Industry examines the drug discovery process, assessing how new technologies have improved effectiveness. Artificial intelligence and machine learning are considered the future for a wide range of disciplines and industries, including the pharmaceutical industry. In an environment where producing a single approved drug costs millions and takes many years of rigorous testing prior to its approval, reducing costs and time is of high interest. This book follows