Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Produk Detail:

  • Author : Anonim
  • Publisher : Academic Press
  • Pages : 288 pages
  • ISBN : 0128178205
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKGenome Plasticity in Health and Disease

Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 08 April 2020
GET THIS BOOKGenome Plasticity in Health and Disease

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors,

Chromatin Signaling and Diseases

Chromatin Signaling and Diseases
  • Author : Olivier Binda,Martin Ernesto Fernandez-Zapico
  • Publisher : Academic Press
  • Release : 06 August 2016
GET THIS BOOKChromatin Signaling and Diseases

Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease
  • Author : Randy L Jirtle,Frederick L. Tyson
  • Publisher : Springer Science & Business Media
  • Release : 16 May 2013
GET THIS BOOKEnvironmental Epigenomics in Health and Disease

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem

Environmental Epigenetics

Environmental Epigenetics
  • Author : L. Joseph Su,Tung-chin Chiang
  • Publisher : Springer
  • Release : 18 May 2015
GET THIS BOOKEnvironmental Epigenetics

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended

Nutritional Epigenomics

Nutritional Epigenomics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 20 July 2019
GET THIS BOOKNutritional Epigenomics

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity,

Ubiquitination Governing DNA Repair

Ubiquitination Governing DNA Repair
  • Author : Effrossyni Boutou,Horst-Werner Stürzbecher
  • Publisher : BoD – Books on Demand
  • Release : 01 August 2018
GET THIS BOOKUbiquitination Governing DNA Repair

DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in

Heart Development and Regeneration

Heart Development and Regeneration
  • Author : Nadia Rosenthal,Richard P. Harvey
  • Publisher : Academic Press
  • Release : 28 May 2010
GET THIS BOOKHeart Development and Regeneration

The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution

Epigenetics in Health and Disease

Epigenetics in Health and Disease
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : FT Press
  • Release : 01 March 2021
GET THIS BOOKEpigenetics in Health and Disease

"After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Cover, p. [4].

Developmental Disabilities

Developmental Disabilities
  • Author : Ahmad Salehi
  • Publisher : BoD – Books on Demand
  • Release : 10 July 2013
GET THIS BOOKDevelopmental Disabilities

Although various developmental disabilities affecting children and adults might have different pathogeneses, underlying mechanisms, and clinical presentations, the current books emphasizes the fact that there are numerous commonalities in methods of understanding, clinical diagnosis, and handling of behavioral abnormalities in affected individuals. For instance, understanding sexual maturation and its consequences in people with intellectual disability would certainly present a path to better understanding of the differences with controls and more effective handling of the unwanted consequences in people affected.