Chromatin Readers in Health and Disease

Chromatin Readers in Health and Disease, Volume 32, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader)?, MBD, SRA, and Methyl-RNA readers. In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders. Enables researchers and clinicians to understand chromatin signaling mechanisms that regulate gene expression through chromatin readers Highlights the role of chromatin readers in a variety of human pathologies, as well as early therapeutics that act on chromatin signaling Includes chapter contributions from international leaders in the field

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  • Author : Olivier Binda
  • Publisher : Academic Press
  • Pages : 416 pages
  • ISBN : 9780128233764
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKChromatin Readers in Health and Disease

Chromatin Readers in Health and Disease

Chromatin Readers in Health and Disease
  • Author : Olivier Binda
  • Publisher : Academic Press
  • Release : 15 December 2021
GET THIS BOOKChromatin Readers in Health and Disease

Chromatin Readers in Health and Disease, Volume 32, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease
  • Author : Randy L Jirtle,Frederick L. Tyson
  • Publisher : Springer Science & Business Media
  • Release : 16 May 2013
GET THIS BOOKEnvironmental Epigenomics in Health and Disease

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem

Transcriptional Gene Regulation in Health and Disease

Transcriptional Gene Regulation in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 15 January 2018
GET THIS BOOKTranscriptional Gene Regulation in Health and Disease

Transcriptional Gene Regulation in Health and Disease, Volume 335, the latest release in the International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks

Myeloid Cells in Health and Disease

Myeloid Cells in Health and Disease
  • Author : Siamon Gordon
  • Publisher : John Wiley & Sons
  • Release : 10 July 2020
GET THIS BOOKMyeloid Cells in Health and Disease

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis,

Epigenomics in Health and Disease

Epigenomics in Health and Disease
  • Author : Mario Fraga,Agustin Fernandez Fernandez
  • Publisher : Academic Press
  • Release : 12 October 2015
GET THIS BOOKEpigenomics in Health and Disease

Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and

Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 08 April 2020
GET THIS BOOKGenome Plasticity in Health and Disease

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors,

Chromatin Signaling and Diseases

Chromatin Signaling and Diseases
  • Author : Olivier Binda,Martin Ernesto Fernandez-Zapico
  • Publisher : Academic Press
  • Release : 06 August 2016
GET THIS BOOKChromatin Signaling and Diseases

Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several

Post-Translational Modifications in Health and Disease

Post-Translational Modifications in Health and Disease
  • Author : Cecilio J. Vidal
  • Publisher : Springer Science & Business Media
  • Release : 13 October 2010
GET THIS BOOKPost-Translational Modifications in Health and Disease

Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential

Toxicoepigenetics

Toxicoepigenetics
  • Author : Shaun D. McCullough,Dana Dolinoy
  • Publisher : Academic Press
  • Release : 02 November 2018
GET THIS BOOKToxicoepigenetics

Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects

Systems Analysis of Chromatin-Related Protein Complexes in Cancer

Systems Analysis of Chromatin-Related Protein Complexes in Cancer
  • Author : Andrew Emili,Jack Greenblatt,Shoshana Wodak
  • Publisher : Springer Science & Business Media
  • Release : 13 August 2013
GET THIS BOOKSystems Analysis of Chromatin-Related Protein Complexes in Cancer

​​​​​​​​​​​​​​​​​​​​​​​ Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field,

Human Epigenomics

Human Epigenomics
  • Author : Carsten Carlberg,Ferdinand Molnár
  • Publisher : Springer
  • Release : 01 February 2018
GET THIS BOOKHuman Epigenomics

The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the

Mechanisms of Gene Regulation

Mechanisms of Gene Regulation
  • Author : Carsten Carlberg,Ferdinand Molnár
  • Publisher : Springer
  • Release : 06 June 2016
GET THIS BOOKMechanisms of Gene Regulation

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences,

The Human Genome in Health and Disease

The Human Genome in Health and Disease
  • Author : Tore Samuelsson
  • Publisher : Garland Science
  • Release : 07 February 2019
GET THIS BOOKThe Human Genome in Health and Disease

The human genome is a linear sequence of roughly 3 billion bases and information regarding this genome is accumulating at an astonishing rate. Inspired by these advances, The Human Genome in Health and Disease: A Story of Four Letters explores the intimate link between sequence information and biological function. A range of sequence-based functional units of the genome are discussed and illustrated with inherited disorders and cancer. In addition, the book considers valuable medical applications related to human genome sequencing, such