Clinical Studies and Therapies in Parkinson s Disease

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson's Disease, and it remains as the most common treatment despite the fact that after 4-6 years it induces severe side effects such as dyskinesia. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies in Parkinson's disease, but efforts have failed at the time of transferring these successful results to preclinical studies. Although there are several publications that warn of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow the development of the disease. Translation of Preclinical Models to Clinical Studies and Therapies in Parkinson's Disease: Translations from Preclinical Models analyses why preclinical models based on exogenous neurotoxins have failed. To develop new pharmacological treatments for Parkinson ́s Disease, the book discusses a more physiological model directly related to metabolism of dopaminergic neurons that are lost before and after the onset of the disease. This book also reviews genetic preclinical models based on genetic mutations associated with the familial form of the disease and preclinical models based on endogenous neurotoxins. Analyses why preclinical models of Parkinson's Disease therapies based on exogenous neurotoxins have failed Proposes a more physiological model directly related to metabolism of dopaminergic neurons Reviews genetic preclinical models based on genetic mutations and preclinical models based on endogenous neurotoxins

Produk Detail:

  • Author : Juan Segura-Aguilar
  • Publisher : Academic Press
  • Pages : 200 pages
  • ISBN : 9780128221204
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKClinical Studies and Therapies in Parkinson s Disease

Clinical Studies and Therapies in Parkinson's Disease

Clinical Studies and Therapies in Parkinson's Disease
  • Author : Juan Segura-Aguilar
  • Publisher : Academic Press
  • Release : 15 September 2021
GET THIS BOOKClinical Studies and Therapies in Parkinson's Disease

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson's Disease, and it remains as the most common treatment despite the fact that after 4-6 years it induces severe side effects such as dyskinesia. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies in Parkinson's disease, but efforts have failed at the time of transferring these successful results to preclinical studies. Although there are several publications that warn of these failures,

Diagnosis and Management in Parkinson's Disease

Diagnosis and Management in Parkinson's Disease
  • Author : Colin R. Martin,Victor R. Preedy
  • Publisher : Academic Press
  • Release : 13 August 2020
GET THIS BOOKDiagnosis and Management in Parkinson's Disease

Diagnosis and Management in Parkinson's Disease: The Neuroscience of Parkinson’s, Volume 1 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything concerning the neurology and neuroscience related to Parkinson’s disease, from chemicals and cells to individuals. The

The New Parkinson's Disease Treatment Book

The New Parkinson's Disease Treatment Book
  • Author : J. Eric Ahlskog, PhD, MD
  • Publisher : Oxford University Press
  • Release : 03 August 2015
GET THIS BOOKThe New Parkinson's Disease Treatment Book

The fundamental guide to the most effective treatments for Parkinson's Disease, from a Mayo Clinic doctor with thirty years of clinical and research experience. In this second edition follow-up to the extremely successful first edition, Dr. Ahlskog draws on thirty years of clinical experience to present the definitive guide to dealing with all aspects of Parkinson's Disease, from treatment options and side effects to the impact of the disease on caregivers and family. Dr. Ahlskog's goal is to educate patients

Balance Dysfunction in Parkinson’s Disease

Balance Dysfunction in Parkinson’s Disease
  • Author : Martina Mancini,John G. Nutt,Fay B. Horak
  • Publisher : Academic Press
  • Release : 14 September 2019
GET THIS BOOKBalance Dysfunction in Parkinson’s Disease

Balance Dysfunction in Parkinson’s Disease: Basic Mechanisms to Clinical Management presents the most updated information on a variety of topics. Sections help clinicians evaluate the types of balance control issues, dynamic balance dysfunction during turning, and the effects of medication, deep brain stimulation, and rehabilitation intervention on balance control. This book is the first to review the four main postural control systems and how they are affected, including balance during quiet stance, reactive postural adjustments to external perturbations, anticipatory

Deep Brain Stimulation for Parkinson's Disease

Deep Brain Stimulation for Parkinson's Disease
  • Author : Gordon H. Baltuch,Matthew B. Stern
  • Publisher : CRC Press
  • Release : 19 March 2007
GET THIS BOOKDeep Brain Stimulation for Parkinson's Disease

Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's

Meta-Ethnography

Meta-Ethnography
  • Author : George W. Noblit,R. Dwight Hare
  • Publisher : SAGE
  • Release : 01 February 1988
GET THIS BOOKMeta-Ethnography

This provocative volume deals with one of the chief criticisms of ethnographic studies, a criticism which centres on their particularism or their insistence on context -- the question is asked: How can these studies be generalized beyond the individual case? Noblit and Hare propose a method -- meta-ethnography -- for synthesizing from qualitative, interpretive studies. They show that ethnographies themselves are interpretive acts, and demonstrate that by translating metaphors and key concepts between ethnographic studies, it is possible to develop

Recent Advances in Parkinson's Disease: Basic research

Recent Advances in Parkinson's Disease: Basic research
  • Author : Anders Björklund,M. Angela Cenci
  • Publisher : Elsevier
  • Release : 09 March 2021
GET THIS BOOKRecent Advances in Parkinson's Disease: Basic research

Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience. Volumes 181 and 182 of Progress in Brain Research provide a rapid view of the major points presently discussed at biological and clinical levels. The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques. The volumes cover of the role of genetics in many endocrine-related

Levodopa pharmacokinetics -from stomach to brain

Levodopa pharmacokinetics -from stomach to brain
  • Author : Maria Nord
  • Publisher : Linköping University Electronic Press
  • Release : 07 January 2019
GET THIS BOOKLevodopa pharmacokinetics -from stomach to brain

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. Several factors affect the availability of orally given LD. Gastric emptying (GE) is one factor and it has been shown to

Principles and Practice of Movement Disorders E-Book

Principles and Practice of Movement Disorders E-Book
  • Author : Stanley Fahn,Joseph Jankovic,Mark Hallett
  • Publisher : Elsevier Health Sciences
  • Release : 09 August 2011
GET THIS BOOKPrinciples and Practice of Movement Disorders E-Book

Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully

Ending Parkinson's Disease

Ending Parkinson's Disease
  • Author : Ray Dorsey,Todd Sherer,Michael S. Okun,Bastiaan R. Bloem
  • Publisher : PublicAffairs
  • Release : 17 March 2020
GET THIS BOOKEnding Parkinson's Disease

Four top experts provide a plan to help prevent the Parkinson's pandemic, improve care and treatment, and end the silence associated with this devastating disease Brain diseases are now the world's leading source of disability. The fastest growing of these is Parkinson's: the number of people with Parkinson's doubled to over 6 million over the last 25 years and is projected to double again by 2040. Harmful pesticides known to cause Parkinson's proliferate, many people remain undiagnosed and untreated, research funding stagnates, and

Rating Scales in Parkinson's Disease

Rating Scales in Parkinson's Disease
  • Author : Cristina Sampaio,Christopher G. Goetz,Anette Schrag
  • Publisher : Oxford University Press
  • Release : 28 June 2012
GET THIS BOOKRating Scales in Parkinson's Disease

For many years, the need to develop valid tools to evaluate signs and symptoms of Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains