Clinical Trial Design Challenges in Mood Disorders

Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. Traditional trial designs are included as well as novel analytic techniques. The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of maintenance studies, and the application of findings into clinical practice. With representation from contributors throughout the world and from academia, industry, regulatory agencies, and advocacy groups, this book will contribute toward improved clinical trial design and valid, precise, and reliable answers about what works better and faster for patients. Summarizes common trial design problems and their solutions Encompasses funding, subject selection, regulatory issues and more Identifies best practices for definitive and generalizable results Includes traditional trial designs and novel analytic techniques Represents academia, industry, regulatory agencies, and advocacy groups

Produk Detail:

  • Author : Mauricio Tohen
  • Publisher : Academic Press
  • Pages : 192 pages
  • ISBN : 0124051766
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKClinical Trial Design Challenges in Mood Disorders

Clinical Trial Design Challenges in Mood Disorders

Clinical Trial Design Challenges in Mood Disorders
  • Author : Mauricio Tohen,Charles Bowden,Andrew A. Nierenberg,John Geddes
  • Publisher : Academic Press
  • Release : 24 January 2015
GET THIS BOOKClinical Trial Design Challenges in Mood Disorders

Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. Traditional trial designs are included as well as novel analytic techniques. The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of

Neuroscience Trials of the Future

Neuroscience Trials of the Future
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release : 07 December 2016
GET THIS BOOKNeuroscience Trials of the Future

On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now,

Small Clinical Trials

Small Clinical Trials
  • Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Small-Number-Participant Clinical Research Trials
  • Publisher : National Academies Press
  • Release : 01 January 2001
GET THIS BOOKSmall Clinical Trials

Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of

Complex Disorders in Pediatric Psychiatry

Complex Disorders in Pediatric Psychiatry
  • Author : David I Driver,Shari Thomas
  • Publisher : Elsevier Health Sciences
  • Release : 27 March 2018
GET THIS BOOKComplex Disorders in Pediatric Psychiatry

Get a quick, expert overview of complex childhood psychiatric disorders from Drs. David I. Driver and Shari Thomas of Healthy Foundations Group. This practical resource presents a summary of today’s current knowledge and best approaches to topics from gender dysphoria to childhood onset schizophrenia and other complex psychiatric disorders. Comprehensive guide for any professional working with children. Consolidates today’s evidence-based information on complex childhood psychiatric disorders into one convenient resource. Provides must-know information on evaluation and management. Covers

The Health Effects of Cannabis and Cannabinoids

The Health Effects of Cannabis and Cannabinoids
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda
  • Publisher : National Academies Press
  • Release : 31 March 2017
GET THIS BOOKThe Health Effects of Cannabis and Cannabinoids

Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release : 06 February 2014
GET THIS BOOKImproving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective

Alzheimer's Disease

Alzheimer's Disease
  • Author : Jolanta Dorszewska,Wojciech Kozubski
  • Publisher : BoD – Books on Demand
  • Release : 18 July 2018
GET THIS BOOKAlzheimer's Disease

Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used

The American Psychiatric Association Practice Guidelines for the Psychiatric Evaluation of Adults, Third Edition

The American Psychiatric Association Practice Guidelines for the Psychiatric Evaluation of Adults, Third Edition
  • Author : American Psychiatric Association
  • Publisher : American Psychiatric Pub
  • Release : 29 July 2015
GET THIS BOOKThe American Psychiatric Association Practice Guidelines for the Psychiatric Evaluation of Adults, Third Edition

Since the publication of the Institute of Medicine (IOM) report Clinical Practice Guidelines We Can Trust in 2011, there has been an increasing emphasis on assuring that clinical practice guidelines are trustworthy, developed in a transparent fashion, and based on a systematic review of the available research evidence. To align with the IOM recommendations and to meet the new requirements for inclusion of a guideline in the National Guidelines Clearinghouse of the Agency for Healthcare Research and Quality (AHRQ), American Psychiatric

The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes

The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes
  • Author : Michael Ritsner
  • Publisher : Springer Science & Business Media
  • Release : 21 April 2009
GET THIS BOOKThe Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms

Novel Designs of Early Phase Trials for Cancer Therapeutics

Novel Designs of Early Phase Trials for Cancer Therapeutics
  • Author : Shivaani Kummar,Chris Takimoto
  • Publisher : Academic Press
  • Release : 22 May 2018
GET THIS BOOKNovel Designs of Early Phase Trials for Cancer Therapeutics

Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate

Cognitive Dysfunction in Bipolar Disorder

Cognitive Dysfunction in Bipolar Disorder
  • Author : Joseph F. Goldberg,Katherine Burdick
  • Publisher : American Psychiatric Pub
  • Release : 20 February 2009
GET THIS BOOKCognitive Dysfunction in Bipolar Disorder

A growing body of clinical and experimental evidence shows that neurocognitive dysfunction is a fundamental -- yet frequently ignored or misidentified -- component of bipolar disorder. The first comprehensive book of its kind, Cognitive Dysfunction in Bipolar Disorder: A Guide for Clinicians compiles the latest data in neuropsychology, neuroimaging, neurogenetics, and functional outcomes research to enable clinicians to more effectively utilize pharmacological and psychotherapeutic techniques in their treatment of bipolar disorder. This volume outlines and demystifies current knowledge about neuropsychological

Textbook of Psychiatric Epidemiology

Textbook of Psychiatric Epidemiology
  • Author : Ming T. Tsuang,Mauricio Tohen,Peter Jones
  • Publisher : John Wiley & Sons
  • Release : 25 March 2011
GET THIS BOOKTextbook of Psychiatric Epidemiology

The new edition of this critically praised textbook continues to provide the most comprehensive overview of the concepts, methods, and research advances in the field; particularly the application of molecular genomics and of neuroimaging. It has been revised and enhanced to capitalize on the strengths of the first and second editions while keeping it up-to-date with the field of psychiatry and epidemiology. This comprehensive publication now includes chapters on experimental epidemiology, gene-environment interactions, the use of case registries, eating disorders,