Companion and Complementary Diagnostics

Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic

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  • Author : Jan Trøst Jørgensen
  • Publisher : Academic Press
  • Pages : 508 pages
  • ISBN : 0128135409
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCompanion and Complementary Diagnostics

Companion and Complementary Diagnostics

Companion and Complementary Diagnostics
  • Author : Jan Trøst Jørgensen
  • Publisher : Academic Press
  • Release : 08 May 2019
GET THIS BOOKCompanion and Complementary Diagnostics

Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It

Companion Diagnostics (CDx) in Precision Medicine

Companion Diagnostics (CDx) in Precision Medicine
  • Author : Il-Jin Kim
  • Publisher : CRC Press
  • Release : 06 March 2019
GET THIS BOOKCompanion Diagnostics (CDx) in Precision Medicine

There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have

Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
  • Author : Michael Mahler
  • Publisher : Elsevier
  • Release : 15 April 2021
GET THIS BOOKPrecision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on AI, its link to PM, and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as artificial intelligence (AI) has gained significant attention in the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems has enabled the generation of large amounts of data, making autoimmunity an ideal target for AI in

Predictive Biomarkers in Oncology

Predictive Biomarkers in Oncology
  • Author : Sunil Badve,George Louis Kumar
  • Publisher : Springer
  • Release : 06 December 2018
GET THIS BOOKPredictive Biomarkers in Oncology

“Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms

Personalised Health Care

Personalised Health Care
  • Author : Stefania Boccia,Róza Ádány,Paolo Villari,Martina C. Cornel,Corrado De Vito,Roberta Pastorino
  • Publisher : Springer Nature
  • Release : 23 November 2020
GET THIS BOOKPersonalised Health Care

Practitioners are increasingly adopting a personalised medicine approach to individually tailored patient care, especially disease diagnosis and treatment with the use of biomarkers. However, development and implementation of such approaches to chronic disease prevention need further investigation and concerted efforts for proper use in healthcare systems. This book provides high-quality, multidisciplinary knowledge from research in personalised medicine, specifically personalised prevention of chronic disease. It addresses different perspectives of prevention in the field, and is the outcome of a four-year work

Drug-Diagnostics Co-Development in Oncology

Drug-Diagnostics Co-Development in Oncology
  • Author : Jan Trøst Jørgensen
  • Publisher : Frontiers E-books
  • Release : 07 November 2014
GET THIS BOOKDrug-Diagnostics Co-Development in Oncology

The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen receptor modulator tamoxifen was developed in the 1970’s for the treatment of breast cancer a positive correlation between receptor status and treatment outcome was found. As a result of this research, it was suggested to use the estrogen-receptor assay as a diagnostic test for selection of patients for tamoxifen treatment. Despite this suggestion was put forward nearly 40 years ago the adaptation of the drug-diagnostic

Innovations for Next-Generation Antibody-Drug Conjugates

Innovations for Next-Generation Antibody-Drug Conjugates
  • Author : Marc Damelin
  • Publisher : Springer
  • Release : 29 May 2018
GET THIS BOOKInnovations for Next-Generation Antibody-Drug Conjugates

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter

Optical and Laser Diagnostics

Optical and Laser Diagnostics
  • Author : C Arcoumanis,K.T.V Grattan
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKOptical and Laser Diagnostics

From the automotive industry to blood flow monitoring, optical techniques and laser diagnostics are becoming integral parts in engineering and medical instrumentation. Written by leading global experts from industry, academic groups, and laboratories, this volume provides an international perspective on both existing applications and leading-edge r

Biomarker Tests for Molecularly Targeted Therapies

Biomarker Tests for Molecularly Targeted Therapies
  • Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on Policy Issues in the Clinical Development and Use of Biomarkers for Molecularly Targeted Therapies
  • Publisher : National Academies Press
  • Release : 30 July 2016
GET THIS BOOKBiomarker Tests for Molecularly Targeted Therapies

Every patient is unique, and the evolving field of precision medicine aims to ensure the delivery of the right treatment to the right patient at the right time. In an era of rapid advances in biomedicine and enhanced understanding of the genetic basis of disease, health care providers increasingly have access to advanced technologies that may identify molecular variations specific to an individual patient, which subsequently can be targeted for treatment. Known as biomarker tests for molecularly targeted therapies, these

Biomarkers in Drug Development

Biomarkers in Drug Development
  • Author : Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
  • Publisher : John Wiley & Sons
  • Release : 20 September 2011
GET THIS BOOKBiomarkers in Drug Development

Discover how biomarkers can boost the success rate of drugdevelopment efforts As pharmaceutical companies struggle to improve the success rateand cost-effectiveness of the drug development process, biomarkershave emerged as a valuable tool. This book synthesizes and reviewsthe latest efforts to identify, develop, and integrate biomarkersas a key strategy in translational medicine and the drugdevelopment process. Filled with case studies, the bookdemonstrates how biomarkers can improve drug development timelines,lower costs, facilitate better compound selection, reducelate-stage attrition, and open the door

An R Companion to Applied Regression

An R Companion to Applied Regression
  • Author : John Fox,Sanford Weisberg
  • Publisher : SAGE Publications
  • Release : 27 September 2018
GET THIS BOOKAn R Companion to Applied Regression

An R Companion to Applied Regression is a broad introduction to the R statistical computing environment in the context of applied regression analysis. John Fox and Sanford Weisberg provide a step-by-step guide to using the free statistical software R, an emphasis on integrating statistical computing in R with the practice of data analysis, coverage of generalized linear models, and substantial web-based support materials. The Third Edition has been reorganized and includes a new chapter on mixed-effects models, new and updated

Ensuring Innovation in Diagnostics for Bacterial Infection

Ensuring Innovation in Diagnostics for Bacterial Infection
  • Author : Chantal Morel,Lindsay McClure,Suzanne Edwards,Dale Sandberg
  • Publisher : World Health Organization
  • Release : 18 May 2022
GET THIS BOOKEnsuring Innovation in Diagnostics for Bacterial Infection

The inappropriate use of antibiotics is a primary cause of the ongoing increase in drug resistance among pathogenic bacteria. The resulting decrease in the efficacy of antibiotics threatens our ability to combat infectious diseases. Rapid, point-of-care tests to identify pathogens and better target the appropriate treatment could greatly improve the use of antibiotics. Yet there are few such tests currently available or being developed despite the rapid pace of medical innovation. Clearly something is inhibiting the much-needed development of new

Impact Evaluation in Practice, Second Edition

Impact Evaluation in Practice, Second Edition
  • Author : Paul J. Gertler,Sebastian Martinez,Patrick Premand,Laura B. Rawlings,Christel M. J. Vermeersch
  • Publisher : World Bank Publications
  • Release : 12 September 2016
GET THIS BOOKImpact Evaluation in Practice, Second Edition

The second edition of the Impact Evaluation in Practice handbook is a comprehensive and accessible introduction to impact evaluation for policy makers and development practitioners. First published in 2011, it has been used widely across the development and academic communities. The book incorporates real-world examples to present practical guidelines for designing and implementing impact evaluations. Readers will gain an understanding of impact evaluations and the best ways to use them to design evidence-based policies and programs. The updated version covers the

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
  • Author : Claudio Carini,Mark Fidock,Alain van Gool
  • Publisher : CRC Press
  • Release : 16 April 2019
GET THIS BOOKHandbook of Biomarkers and Precision Medicine

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into