Cytokines and the Brain

This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer’s disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment. *Opens a new page of neuro-immunobiology and provides substantive evidence for the promise of this field in the treatment of disease *Summarizes current understanding on the presence and function of central nervous system (CNS) cytokines and their receptors in a variety of CNS cells during health and disease *Includes novel approaches to the treatment of CNS disorders based on new experimental data *Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment

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  • Author : Anonim
  • Publisher : Elsevier
  • Pages : 608 pages
  • ISBN : 9780080559353
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCytokines and the Brain

Cytokines and the Brain

Cytokines and the Brain
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 18 June 2008
GET THIS BOOKCytokines and the Brain

This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a

Cytokines as Players of Neuronal Plasticity and Sensitivity to Environment in Healthy and Pathological Brain

Cytokines as Players of Neuronal Plasticity and Sensitivity to Environment in Healthy and Pathological Brain
  • Author : Silvia Alboni,Laura Maggi
  • Publisher : Frontiers Media SA
  • Release : 18 March 2016
GET THIS BOOKCytokines as Players of Neuronal Plasticity and Sensitivity to Environment in Healthy and Pathological Brain

It is now accepted that immune molecules are not only present within the brain during pathology but they exert physiological functions in the “healthy” brain as well. Increasing evidence points to a neuro-modulatory role of cytokines and chemokines (CHEMOtactic cytoKINES) in basal transmission and plasticity processes where signaling between peri-synaptic astrocytes, microglia and neurons plays an important role. Nevertheless, the exact mechanisms as to how cytokines, and in particular chemokines, participate in the molecular and cellular processes thought to subserve

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration
  • Author : Phillip K. Peterson,Michal Toborek
  • Publisher : Springer
  • Release : 11 July 2014
GET THIS BOOKNeuroinflammation and Neurodegeneration

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the

Cytokines and the CNS

Cytokines and the CNS
  • Author : Richard M. Ransohoff,Etty N. Benveniste
  • Publisher : CRC Press
  • Release : 31 October 2005
GET THIS BOOKCytokines and the CNS

Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines. The similarity between factors involved in inflammation or immunity, and those

Mechanisms of Neuroinflammation

Mechanisms of Neuroinflammation
  • Author : Gonzalo Emiliano Aranda Abreu
  • Publisher : BoD – Books on Demand
  • Release : 23 August 2017
GET THIS BOOKMechanisms of Neuroinflammation

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of

The Neuroimmunological Basis of Behavior and Mental Disorders

The Neuroimmunological Basis of Behavior and Mental Disorders
  • Author : Allan Siegel,Steven S. Zalcman
  • Publisher : Springer Science & Business Media
  • Release : 09 November 2008
GET THIS BOOKThe Neuroimmunological Basis of Behavior and Mental Disorders

For many years, the immune and central nervous systems were thought to function independently with little or no interaction between the two. This view has und- gone dramatic changes over the past three decades. Indeed, we now know that there exists various feedback loops between the brain and immune systems that impact signi cantly upon different behavioral processes, including normal behavior and mental disorders. Pioneering efforts in generating this change were initiated by a number of early investigators. Included were

The Inflamed Mind

The Inflamed Mind
  • Author : Edward Bullmore
  • Publisher : Picador
  • Release : 31 December 2018
GET THIS BOOKThe Inflamed Mind

As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge profressor of psychiatry Edward Bullmore reveals the breakthrough

Neuroinflammation, Resolution, and Neuroprotection in the Brain

Neuroinflammation, Resolution, and Neuroprotection in the Brain
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release : 01 October 2021
GET THIS BOOKNeuroinflammation, Resolution, and Neuroprotection in the Brain

Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart

Cytokines, Stress, and Depression

Cytokines, Stress, and Depression
  • Author : Robert Dantzer,Emmanuelle E. Wollmann,Raz Yirmiya
  • Publisher : Springer Science & Business Media
  • Release : 23 November 2007
GET THIS BOOKCytokines, Stress, and Depression

Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between

Biomarkers of Neuroinflammation

Biomarkers of Neuroinflammation
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release : 16 March 2018
GET THIS BOOKBiomarkers of Neuroinflammation

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the

The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications

The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications
  • Author : Helen E. Scharfman
  • Publisher : Elsevier
  • Release : 22 September 2011
GET THIS BOOKThe Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications

The dentate gyrus is a part of the brain that has been a topic of intense interest since the beginning of neuroscience, and pioneering studies from the distant and recent past attest to this. One of the reasons for such interest is that this structure provides some of the most remarkable examples of plasticity within the nervous system. In addition, it is critical to normal cognitive function, although exactly how and when is still a question that eludes answers. Furthermore,

Cytokines and Mental Health

Cytokines and Mental Health
  • Author : Ziad Kronfol
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKCytokines and Mental Health

Cytokines and Mental Health explores the relationship between cytokines, neural circuitry and mental health. It is interdisciplinary and "translational", bringing together information that spans the spectrum from the molecular and cellular levels to the patient and the clinic. Content includes chapters that discuss cytokine pathways in the brain, the neurochemical and neuroendocrine effects of cytokines, and the behavioral effects of cytokines including sickness behavior. These chapters in basic research are followed by a more clinical section that discusses the role

Depression: From Psychopathology to Pharmacotherapy

Depression: From Psychopathology to Pharmacotherapy
  • Author : J.F. Cryan,B.E. Leonard
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 17 November 2010
GET THIS BOOKDepression: From Psychopathology to Pharmacotherapy

Despite the availability of antidepressants for over 40 years, a substantial proportion of depressed patients do not respond adequately to treatment. Failure to respond effectively to treatment contributes to physical ill-health and psychiatric morbidity, often resulting in premature death of the depressed patient. The purpose of this volume is to consider the possible reasons for the limitations of the currently available antidepressants, to examine the advances in our understanding of the psychopathology of depression and how such knowledge may assist in

Brain Edema XIII

Brain Edema XIII
  • Author : Julian T. Hoff,Richard F. Keep,Guohua Xi,Ya Hua
  • Publisher : Springer Science & Business Media
  • Release : 22 June 2006
GET THIS BOOKBrain Edema XIII

This volume contains 93 papers from internationally recognized experts in the field of brain edema and brain injury. The papers include human and animal studies on edema following stroke, cerebral hemorrhage, traumatic brain injury, spinal cord injury and hydrocephalus. Papers also address fluid dynamics in the brain (including the role of aquaporins).

Inflammation and Stroke

Inflammation and Stroke
  • Author : Giora Z. Feuerstein
  • Publisher : Springer
  • Release : 06 December 2012
GET THIS BOOKInflammation and Stroke

Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events in brain ischemia. New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The recognition of inflammation as a fundamental response to brain ischemia provides novel opportunities for new anti-inflammatory therapies. For the first time,