Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology

Stochastic kinetic methods are currently considered to be the most realistic and elegant means of representing and simulating the dynamics of biochemical and biological networks. Deterministic versus stochastic modelling in biochemistry and systems biology introduces and critically reviews the deterministic and stochastic foundations of biochemical kinetics, covering applied stochastic process theory for application in the field of modelling and simulation of biological processes at the molecular scale. Following an overview of deterministic chemical kinetics and the stochastic approach to biochemical kinetics, the book goes onto discuss the specifics of stochastic simulation algorithms, modelling in systems biology and the structure of biochemical models. Later chapters cover reaction-diffusion systems, and provide an analysis of the Kinfer and BlenX software systems. The final chapter looks at simulation of ecodynamics and food web dynamics. Introduces mathematical concepts and formalisms of deterministic and stochastic modelling through clear and simple examples Presents recently developed discrete stochastic formalisms for modelling biological systems and processes Describes and applies stochastic simulation algorithms to implement a stochastic formulation of biochemical and biological kinetics

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  • Author : Paola Lecca
  • Publisher : Elsevier
  • Pages : 390 pages
  • ISBN : 1908818212
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKDeterministic Versus Stochastic Modelling in Biochemistry and Systems Biology

Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology

Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology
  • Author : Paola Lecca,Ian Laurenzi,Ferenc Jordan
  • Publisher : Elsevier
  • Release : 09 April 2013
GET THIS BOOKDeterministic Versus Stochastic Modelling in Biochemistry and Systems Biology

Stochastic kinetic methods are currently considered to be the most realistic and elegant means of representing and simulating the dynamics of biochemical and biological networks. Deterministic versus stochastic modelling in biochemistry and systems biology introduces and critically reviews the deterministic and stochastic foundations of biochemical kinetics, covering applied stochastic process theory for application in the field of modelling and simulation of biological processes at the molecular scale. Following an overview of deterministic chemical kinetics and the stochastic approach to biochemical

Identifiability and Regression Analysis of Biological Systems Models

Identifiability and Regression Analysis of Biological Systems Models
  • Author : Paola Lecca
  • Publisher : Springer Nature
  • Release : 05 March 2020
GET THIS BOOKIdentifiability and Regression Analysis of Biological Systems Models

This richly illustrated book presents the objectives of, and the latest techniques for, the identifiability analysis and standard and robust regression analysis of complex dynamical models. The book first provides a definition of complexity in dynamic systems by introducing readers to the concepts of system size, density of interactions, stiff dynamics, and hybrid nature of determination. In turn, it presents the mathematical foundations of and algorithmic procedures for model structural and practical identifiability analysis, multilinear and non-linear regression analysis, and

Analysis of Biological Systems

Analysis of Biological Systems
  • Author : Corrado Priami,Melissa J Morine
  • Publisher : World Scientific
  • Release : 29 January 2015
GET THIS BOOKAnalysis of Biological Systems

Modeling is fast becoming fundamental to understanding the processes that define biological systems. High-throughput technologies are producing increasing quantities of data that require an ever-expanding toolset for their effective analysis and interpretation. Analysis of high-throughput data in the context of a molecular interaction network is particularly informative as it has the potential to reveal the most relevant network modules with respect to a phenotype or biological process of interest. Analysis of Biological Systems collects classical material on analysis, modeling and

Theoretical Physics for Biological Systems

Theoretical Physics for Biological Systems
  • Author : Paola Lecca,Angela Re
  • Publisher : CRC Press
  • Release : 30 January 2019
GET THIS BOOKTheoretical Physics for Biological Systems

Quantum physics provides the concepts and their mathematical formalization that lend themselves to describe important properties of biological networks topology, such as vulnerability to external stress and their dynamic response to changing physiological conditions. A theory of networks enhanced with mathematical concepts and tools of quantum physics opens a new area of biological physics, the one of systems biological physics.

Introduction to Modeling and Simulation with MATLAB® and Python

Introduction to Modeling and Simulation with MATLAB® and Python
  • Author : Steven I. Gordon,Brian Guilfoos
  • Publisher : CRC Press
  • Release : 12 July 2017
GET THIS BOOKIntroduction to Modeling and Simulation with MATLAB® and Python

Introduction to Modeling and Simulation with MATLAB and Python is intended for students and professionals in science, social science, and engineering that wish to learn the principles of computer modeling, as well as basic programming skills. The book content focuses on meeting a set of basic modeling and simulation competencies that were developed as part of several National Science Foundation grants. Even though computer science students are much more expert programmers, they are not often given the opportunity to see

Phenotypic Switching

Phenotypic Switching
  • Author : Herbert Levine,Mohit Kumar Jolly,Prakash Kulkarni,Vidyanand Nanjundiah
  • Publisher : Academic Press
  • Release : 10 June 2020
GET THIS BOOKPhenotypic Switching

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance,

Bacterial Cellular Metabolic Systems

Bacterial Cellular Metabolic Systems
  • Author : K. Shimizu
  • Publisher : Elsevier
  • Release : 26 March 2013
GET THIS BOOKBacterial Cellular Metabolic Systems

The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches.

Bioinformatics for Biomedical Science and Clinical Applications

Bioinformatics for Biomedical Science and Clinical Applications
  • Author : K-H Liang
  • Publisher : Elsevier
  • Release : 31 July 2013
GET THIS BOOKBioinformatics for Biomedical Science and Clinical Applications

Contemporary biomedical and clinical research is undergoing constant development thanks to the rapid advancement of various high throughput technologies at the DNA, RNA and protein levels. These technologies can generate vast amounts of raw data, making bioinformatics methodologies essential in their use for basic biomedical and clinical applications. Bioinformatics for biomedical science and clinical applications demonstrates what these cutting-edge technologies can do and examines how to design an appropriate study, including how to deal with data and address specific clinical

Allergens and Respiratory Pollutants

Allergens and Respiratory Pollutants
  • Author : Marc A. Williams
  • Publisher : Elsevier
  • Release : 18 July 2011
GET THIS BOOKAllergens and Respiratory Pollutants

Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links

Concepts and Techniques in Genomics and Proteomics

Concepts and Techniques in Genomics and Proteomics
  • Author : N Saraswathy,P Ramalingam
  • Publisher : Elsevier
  • Release : 01 July 2011
GET THIS BOOKConcepts and Techniques in Genomics and Proteomics

Concepts and techniques in genomics and proteomics covers the important concepts of high-throughput modern techniques used in the genomics and proteomics field. Each technique is explained with its underlying concepts, and simple line diagrams and flow charts are included to aid understanding and memory. A summary of key points precedes each chapter within the book, followed by detailed description in the subsections. Each subsection concludes with suggested relevant original references. Provides definitions for key concepts Case studies are included to

The Funding of Biopharmaceutical Research and Development

The Funding of Biopharmaceutical Research and Development
  • Author : David R Williams
  • Publisher : Elsevier
  • Release : 31 October 2013
GET THIS BOOKThe Funding of Biopharmaceutical Research and Development

The funding of biopharmaceutical research and development provides a comprehensive critical review of the funding of research and development (R&D) in the human biopharmaceutical market sector. It addresses both private and public funding sources available in the US and internationally. The biopharmaceutical market is among the most research-intensive market sectors globally. Clinical researchers face a multitude of public and private funding options with respect to bringing their idea or innovation to market. These funding options are continually changing and

Matlab® in Bioscience and Biotechnology

Matlab® in Bioscience and Biotechnology
  • Author : Leonid Burstein
  • Publisher : Elsevier
  • Release : 05 June 2011
GET THIS BOOKMatlab® in Bioscience and Biotechnology

MATLAB® in bioscience and biotechnology presents an introductory Matlab course oriented towards various collaborative areas of biotechnology and bioscience. It concentrates on Matlab fundamentals and gives examples of its application to a wide range of current bioengineering problems in computational biology, molecular biology, bio-kinetics, biomedicine, bioinformatics, and biotechnology. In the last decade Matlab has been presented to students as the first computer program they learn. Consequently, many non-programmer students, engineers and scientists have come to regard it as user-friendly and

Nanoparticulate Drug Delivery

Nanoparticulate Drug Delivery
  • Author : Vandana Patravale,Prajakta Dandekar,Ratnesh Jain
  • Publisher : Elsevier
  • Release : 31 October 2012
GET THIS BOOKNanoparticulate Drug Delivery

Nanotechnology-based therapeutics, operating at scales of billionths of a metre, have great potential for future expansion in altering the scale and methods of drug delivery. The availability of these novel formulations to once-inaccessible areas of the body has greatly expanded the therapeutic window of existing drug molecules. Nanoparticulate drug delivery highlights and examines the transition of nanoparticulate drug delivery systems from the laboratory into a commercially viable sector. The first chapters of the book provide an overview of the use

Biobanks

Biobanks
  • Author : Antonella De Robbio
  • Publisher : Elsevier
  • Release : 26 November 2012
GET THIS BOOKBiobanks

Biobanks represent an invaluable research tool and, as a result of their intrinsic and extrinsic nature, may be looked upon as archives or repositories largely made up of libraries, or collections of content where the content is the biological material derived from different individuals or species, representing valuable tangible assets. Biobanks analyses aspects of the commons and common intellectual property relating to the concepts of private property, not only concerning data but biological materials as well, and the advantages and

Transporters in Drug Discovery and Development

Transporters in Drug Discovery and Development
  • Author : Yurong Lai
  • Publisher : Woodhead Publishing
  • Release : 22 August 2014
GET THIS BOOKTransporters in Drug Discovery and Development

Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery