DNA Modifications in the Brain

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. Provides a comprehensive overview of the many facets of DNA modifications Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels Contains contributions by influential leaders in the field Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance

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  • Author : Timothy W Bredy
  • Publisher : Academic Press
  • Pages : 180 pages
  • ISBN : 0128017813
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKDNA Modifications in the Brain

DNA Modifications in the Brain

DNA Modifications in the Brain
  • Author : Timothy W Bredy
  • Publisher : Academic Press
  • Release : 23 December 2016
GET THIS BOOKDNA Modifications in the Brain

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
  • Author : Yogesh Dwivedi
  • Publisher : CRC Press
  • Release : 25 June 2012
GET THIS BOOKThe Neurobiological Basis of Suicide

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
  • Publisher : Academic Press
  • Release : 31 December 2012
GET THIS BOOKEpigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter

Neuropsychiatric Disorders and Epigenetics

Neuropsychiatric Disorders and Epigenetics
  • Author : Dag Yasui,Jacob Peedicayil,Dennis R. Grayson
  • Publisher : Academic Press
  • Release : 15 November 2016
GET THIS BOOKNeuropsychiatric Disorders and Epigenetics

Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects

DNA Modifications

DNA Modifications
  • Author : Alexey Ruzov,Martin Gering
  • Publisher : Humana
  • Release : 22 August 2020
GET THIS BOOKDNA Modifications

This book provides an overview of methods and experimental protocols that are currently used to analyze the presence and abundance of non-canonical DNA nucleotides in different biological systems. Focusing particularly on the newly discovered and less studied DNA modifications that are enzymatically produced and are likely to play specific roles in various biological processes, the volume explores chromatography- and mass spectrometry-based techniques for the detection and quantification of DNA modifications, antibody-based approaches to study their spatial distribution in different cells

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease
  • Author : Michel Neidhart
  • Publisher : Academic Press
  • Release : 11 August 2015
GET THIS BOOKDNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as

Chromatin Signaling and Neurological Disorders

Chromatin Signaling and Neurological Disorders
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 May 2019
GET THIS BOOKChromatin Signaling and Neurological Disorders

Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin

Environmental Epigenetics

Environmental Epigenetics
  • Author : L. Joseph Su,Tung-chin Chiang
  • Publisher : Springer
  • Release : 18 May 2015
GET THIS BOOKEnvironmental Epigenetics

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended

Nutritional Epigenomics

Nutritional Epigenomics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 20 July 2019
GET THIS BOOKNutritional Epigenomics

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity,

Stem Cell Epigenetics

Stem Cell Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 14 August 2020
GET THIS BOOKStem Cell Epigenetics

Stem Cell Epigenetics, Volume 16, examines how epigenetics are involved in stem cell differentiation, how a stem cell rapidly transitions into a molecularly distinct cell type, and how this process may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, epigenetic regulation of reprogramming, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, epigenetics and disease modeling, organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation,

Autism

Autism
  • Author : Michael Fitzgerald,Jane Yip
  • Publisher : BoD – Books on Demand
  • Release : 12 April 2017
GET THIS BOOKAutism

This book opens with a discussion of neurodiversity and an elaboration of the diagnosis of autism. It then examines factors correlating with autism, including sex bias, month of birth, migration and impact of infant feeding. The next section is on the impact of autism. The neurobiology and genetic section deals with epigenetics and intracellular pathways associated with etiology. The development and behaviour section deals with proprioceptive profiles and joint attention in autism. The final section focuses on interventions including mindfulness,

Epigenetic Modifications and Viral Infections

Epigenetic Modifications and Viral Infections
  • Author : Silvia Carolina Galvan,Alejandro García Carrancá,Félix Recillas-Targa,Jiuzhou Song
  • Publisher : Frontiers Media SA
  • Release : 09 July 2015
GET THIS BOOKEpigenetic Modifications and Viral Infections

Epigenetics is defined as the study of modifications of the genome, heritable during cell division that does not involve changes in DNA sequences. Up to date, epigenetic modifications involve at least three general mechanisms regulating gene expression: histone modifications, DNA methylation, and non-coding RNAs (ncRNAs). For the past two decades, an explosion in our interest and understanding of epigenetic mechanisms has been seen. This mainly based on the influence that epigenetic alterations have on an amazing number of biological processes,

Handbook of Neurobehavioral Genetics and Phenotyping

Handbook of Neurobehavioral Genetics and Phenotyping
  • Author : Valter Tucci
  • Publisher : John Wiley & Sons
  • Release : 06 March 2017
GET THIS BOOKHandbook of Neurobehavioral Genetics and Phenotyping

The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour. Moreover, while biological sciences are progressing towards a

Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome

Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome
  • Author : Tania L Roth,David M Diamond,Karestan C Koenen
  • Publisher : Frontiers Media SA
  • Release : 14 April 2015
GET THIS BOOKEpigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome

This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in

Gadd45 Stress Sensor Genes

Gadd45 Stress Sensor Genes
  • Author : Dan A. Liebermann,Barbara Hoffman
  • Publisher : Springer Science & Business Media
  • Release : 08 October 2013
GET THIS BOOKGadd45 Stress Sensor Genes

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.