DNA Repair in Cancer Therapy

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Produk Detail:

  • Author : Mark R. Kelley
  • Publisher : Academic Press
  • Pages : 464 pages
  • ISBN : 0128035994
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKDNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy
  • Author : Mark R. Kelley,Melissa L. Fishel
  • Publisher : Academic Press
  • Release : 07 June 2016
GET THIS BOOKDNA Repair in Cancer Therapy

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the

DNA Repair and Cancer

DNA Repair and Cancer
  • Author : Srinivasan Madhusudan,David M. Wilson III
  • Publisher : CRC Press
  • Release : 22 January 2013
GET THIS BOOKDNA Repair and Cancer

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators,

New Research Directions in DNA Repair

New Research Directions in DNA Repair
  • Author : Clark Chen
  • Publisher : BoD – Books on Demand
  • Release : 22 May 2013
GET THIS BOOKNew Research Directions in DNA Repair

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

Advances in DNA Repair in Cancer Therapy

Advances in DNA Repair in Cancer Therapy
  • Author : Lawrence Panasci,Raquel Aloyz,Moulay Alaoui-Jamali
  • Publisher : Springer Science & Business Media
  • Release : 09 December 2012
GET THIS BOOKAdvances in DNA Repair in Cancer Therapy

​A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK. The book captures-for both cancer researchers and oncologists dealing with hallmark "

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy
  • Author : Lawrence C. Panasci,Moulay A. Alaoui-Jamali
  • Publisher : Springer Science & Business Media
  • Release : 19 March 2004
GET THIS BOOKDNA Repair in Cancer Therapy

A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book

PARP Inhibitors for Cancer Therapy

PARP Inhibitors for Cancer Therapy
  • Author : Nicola J. Curtin,Ricky A. Sharma
  • Publisher : Humana Press
  • Release : 13 June 2015
GET THIS BOOKPARP Inhibitors for Cancer Therapy

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are

Base Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design

Base Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design
  • Author : Wilson Iii David M
  • Publisher : World Scientific
  • Release : 08 December 2016
GET THIS BOOKBase Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design

This book will serve as the preeminent text book on the topic of "base excision repair", a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes. The book, which includes contributions from many of the world leaders in the field, provides a detailed description of the molecular mechanisms of base excision repair, as well as its emerging relationship to epigenetic regulation, the aging

System Biology Analysis of the Role of DNA Repair in Cancer Treatment Outcome

System Biology Analysis of the Role of DNA Repair in Cancer Treatment Outcome
  • Author : Mengdi Qian
  • Publisher : Unknown Publisher
  • Release : 25 May 2022
GET THIS BOOKSystem Biology Analysis of the Role of DNA Repair in Cancer Treatment Outcome

Cancer is one of the most lethal and hard to cure diseases. The common treatments for cancer include surgery, radiation therapy, chemotherapy, immunotherapy and hormone therapy. Ionizing radiation (IR) is one of the main clinical treatments for cancer and it works by inducing DNA double strand breaks (DSBs), which are the most toxic DNA lesions that lead to cell death. The effectiveness of IR treatment depends on the amount of induced damage and the DNA damage repair status of the

Targeting the DNA Damage Response for Anti-Cancer Therapy

Targeting the DNA Damage Response for Anti-Cancer Therapy
  • Author : John Pollard,Nicola Curtin
  • Publisher : Springer
  • Release : 26 May 2018
GET THIS BOOKTargeting the DNA Damage Response for Anti-Cancer Therapy

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such

Cancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets

Cancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets
  • Author : Marcel van Vugt,H. Christian Reinhardt
  • Publisher : Frontiers Media SA
  • Release : 17 October 2016
GET THIS BOOKCancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets

For this eBook, and the associated Research Topic in Frontiers in Genetics, entitled: ‘Cancer-associated defects in the DNA damage response: drivers for malignant transformation and potential therapeutic targets’ we have selected 10 papers that each discusses important, yet distinct aspects of the response to DNA damage in normal cells and cancer cells. Using an evolutionary conserved signaling network called the ‘DNA damage response (DDR)’ cells maintain the integrity of their genome, and thus safeguard cellular functioning and the ability to create

DNA Repair and Cancer

DNA Repair and Cancer
  • Author : Srinivasan Madhusudan,David M. Wilson III
  • Publisher : CRC Press
  • Release : 22 January 2013
GET THIS BOOKDNA Repair and Cancer

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators,

DNA Damage and Repair

DNA Damage and Repair
  • Author : A. Castellani
  • Publisher : Springer Science & Business Media
  • Release : 09 March 2013
GET THIS BOOKDNA Damage and Repair

The First International Congress on DNA Damage and Repair was held in Rome, Italy, July 12-17, 1987. It was organized by the Italian Com mission for Nuclear Alternative Energy Sources. The subject of DNA damage and repair involves almost all the fields ofbidogical sciences. Some of the more prominent ones include carcino genesis, photobiology, radiation biology, aging, enzymology, genetics, and molecular biology. These individual fields have their own interna tional meetings and although the meetings often have sessions devoted to DNA