Domino Reactions in Drug Discovery

Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors. Features illustrated schemes with mechanisms, procedures and results Includes a compendium of Domino Name Reactions for drugs Provides a concise, comprehensive coverage of domino reactions in drug discovery, with a focus on sustainable practices

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  • Author : Shanta Bhar
  • Publisher : Elsevier
  • Pages : 315 pages
  • ISBN : 9780128193747
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKDomino Reactions in Drug Discovery

Domino Reactions in Drug Discovery

Domino Reactions in Drug Discovery
  • Author : Shanta Bhar
  • Publisher : Elsevier
  • Release : 01 October 2020
GET THIS BOOKDomino Reactions in Drug Discovery

Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at

Diversity-Oriented Synthesis

Diversity-Oriented Synthesis
  • Author : Andrea Trabocchi
  • Publisher : John Wiley & Sons
  • Release : 17 June 2013
GET THIS BOOKDiversity-Oriented Synthesis

Discover an enhanced synthetic approach to developing andscreening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developinglarge collections of structurally diverse small molecules as probesto investigate biological pathways. This book presents the mosteffective methods in diversity-oriented synthesis for creatingsmall molecule collections. It offers tested and proven strategiesfor developing diversity-oriented synthetic libraries and screeningmethods for identifying ligands. Lastly, it explores some promisingnew applications based on diversity-oriented synthesis that havethe potential to dramatically advance studies in drug discovery andchemical biology.

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis
  • Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
  • Publisher : John Wiley & Sons
  • Release : 13 December 2006
GET THIS BOOKDomino Reactions in Organic Synthesis

Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis
  • Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
  • Publisher : John Wiley & Sons
  • Release : 13 December 2006
GET THIS BOOKDomino Reactions in Organic Synthesis

Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Multicomponent Reactions

Multicomponent Reactions
  • Author : Jieping Zhu,Hugues Bienaymé
  • Publisher : John Wiley & Sons
  • Release : 06 March 2006
GET THIS BOOKMulticomponent Reactions

In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic

Comprehensive Organic Synthesis

Comprehensive Organic Synthesis
  • Author : Anonim
  • Publisher : Newnes
  • Release : 14 February 2014
GET THIS BOOKComprehensive Organic Synthesis

The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on

Asymmetric Domino Reactions

Asymmetric Domino Reactions
  • Author : Hélène Pellissier
  • Publisher : Royal Society of Chemistry
  • Release : 13 March 2013
GET THIS BOOKAsymmetric Domino Reactions

This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of

Interagency Coordination in Drug Research and Regulation: Testimony and exhibits (including subsequent correspondence) on: 1) Commission on Drug safety; 2) Pharmaceutical Manufacturers Association; 3) Medical education on drug therapy and other drug issues

Interagency Coordination in Drug Research and Regulation: Testimony and exhibits (including subsequent correspondence) on: 1) Commission on Drug safety; 2) Pharmaceutical Manufacturers Association; 3) Medical education on drug therapy and other drug issues
  • Author : United States. Congress. Senate. Committee on Government Operations
  • Publisher : Unknown Publisher
  • Release : 05 March 1964
GET THIS BOOKInteragency Coordination in Drug Research and Regulation: Testimony and exhibits (including subsequent correspondence) on: 1) Commission on Drug safety; 2) Pharmaceutical Manufacturers Association; 3) Medical education on drug therapy and other drug issues

Domino Reactions

Domino Reactions
  • Author : Lutz F. Tietze
  • Publisher : John Wiley & Sons
  • Release : 23 December 2013
GET THIS BOOKDomino Reactions

The follow-up to the successful "Domino Reaction in Organic Synthesis", this ready reference brings up to date on the original concept. The chapters have been arranged according to the name of well-known transformations of the first step and in combination with the formed products. Each chapter is written by an internationally renowned expert, and the book is edited by L. F. Tietze, who established the concept of domino reactions. The one-stop source for all synthetic chemists to improve the synthetic

Asymmetric Domino Reactions

Asymmetric Domino Reactions
  • Author : Helene Pellissier
  • Publisher : Royal Society of Chemistry
  • Release : 13 March 2013
GET THIS BOOKAsymmetric Domino Reactions

This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of

Classics in Total Synthesis II

Classics in Total Synthesis II
  • Author : K. C. Nicolaou,S. A. Snyder
  • Publisher : Wiley-VCH
  • Release : 17 October 2003
GET THIS BOOKClassics in Total Synthesis II

Classics in Total Synthesis II is the long awaited sequel to Classics in Total Synthesis, a book that has made its mark as a superb tool for educating students and practitioners alike in the art of organic synthesis since its introduction in 1996. In this highly welcomed new volume, K. C. Nicolaou and Scott A. Snyder discuss in detail the most impressive accomplishments in natural product total synthesis during the 1990s and the first years of the 21st century. While all

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
  • Author : Carmen Avendano,J. Carlos Menendez
  • Publisher : Elsevier
  • Release : 11 June 2015
GET THIS BOOKMedicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience
  • Author : Zbigniew J. Witczak,Roman Bielski
  • Publisher : John Wiley & Sons
  • Release : 14 January 2016
GET THIS BOOKDomino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

The book consists of a brief introduction, a foreward provided byprofessor Danishefsky of Columbia University, and about 14 –16 chapters, each written by one or two eminent scholars/authorsdescribing their recent research in the area of either dominoreactions or intramolecular rearrangements in carbohydratechemistry. Three or four chapters will be reviews. The domino (cascade, tandem)reactions are always intramolecular. They are usually very fast,clean and offer highly complex structures in a one pot process.Intramolecular rearrangements offer very similar advantages andoften lead

Concepts and Case Studies in Chemical Biology

Concepts and Case Studies in Chemical Biology
  • Author : Herbert Waldmann,Petra Janning
  • Publisher : John Wiley & Sons
  • Release : 30 June 2014
GET THIS BOOKConcepts and Case Studies in Chemical Biology

Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years. Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design
  • Author : Bimal K. Banik
  • Publisher : Elsevier
  • Release : 27 March 2020
GET THIS BOOKGreen Approaches in Medicinal Chemistry for Sustainable Drug Design

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and