Drug Biomembrane Interaction Studies

The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material. Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions. Summarizes and updates the recent development in a unique handbook format Consists of a combination of scientific updates within the field Contains chapters written by some of the highest-level experts in the field of DSC

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  • Author : Rosario Pignatello
  • Publisher : Elsevier
  • Pages : 440 pages
  • ISBN : 1908818344
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKDrug Biomembrane Interaction Studies

Drug-Biomembrane Interaction Studies

Drug-Biomembrane Interaction Studies
  • Author : Rosario Pignatello
  • Publisher : Elsevier
  • Release : 31 October 2013
GET THIS BOOKDrug-Biomembrane Interaction Studies

The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : A. Fortunato
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOKDrug–biomembrane interaction studies

In DSC, the heat flow in and out of a sample and a reference material is measured as a function of temperature as the sample is heated, cooled, or held isothermally at constant temperature. The measurement signal is the energy absorbed or released by the sample in milliwatts. DSC can detect endothermic and exothermic effects, determine peak areas (transition and reaction enthalpies), determine temperatures that characterize a peak or other effects, and measure specific heat capacity. Since the end of

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : M.H. Chiu,N.S. Berezowski,E.J. Prenner
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOKDrug–biomembrane interaction studies

DSC is a straightforward, non-perturbing thermodynamic technique first developed in the early 1960s. The large number of parameters and the high sensitivity has made DSC one of the key calorimetric tools used for investigating thermodynamic properties of biopolymers, proteins, peptides and nucleic acids. There are numerous reviews covering the different macromolecular applications of DSC: this chapter will primarily focus on proteins and nucleic acids.

Drug-Membrane Interactions

Drug-Membrane Interactions
  • Author : Joachim K. Seydel,Michael Wiese
  • Publisher : John Wiley & Sons
  • Release : 10 July 2009
GET THIS BOOKDrug-Membrane Interactions

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : R. Pignatello
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOKDrug–biomembrane interaction studies

DSC studies of the interaction between drugs or other biologically active compounds with biomembrane models has often been associated or integrated with other analytical methodologies. The information gained from various techniques can depict the different and complex elements that compose such interactions. This chapter will summarize some recent examples of successfully combining DSC with other physico-chemical methods, such as spectroscopy, chromatography, calorimetry, the Langmuir–Blodgett film technique and microscopy.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : C. Carbone,R. Pignatello
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOKDrug–biomembrane interaction studies

Interest in using DSC to study the interaction between different compounds and biomembrane models has increased in the last 20years. This is confirmed by the number of published research studies concerning the feasibility of investigating the behavior of different molecules, such as local anesthetics, anticancer drugs, anti-inflammatory drugs, antioxidants, antibiotics, peptides, proteins, polymers, surfactants, genetic materials, macromolecules, and also drug delivery systems (DDSs). This chapter provides a general consideration of the current applications of DSC in evaluating the interaction of

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : T. Musumeci,G. Puglisi
  • Publisher : Elsevier Inc. Chapters
  • Release : 31 October 2013
GET THIS BOOKDrug–biomembrane interaction studies

Antimicrobial agents are from different classes of molecules that suppress multiplication and growth of or kill microorganisms such as bacteria, fungi, or viruses. The precise mechanism of action of some antimicrobial agents is unknown but they must interact with or cross the cell membrane to have an effect. Identification of the damage induced by these compounds is difficult due to the complexity of cell membranes. Studying interactions using membrane models is a first step in obtaining elementary information about the

Methods in Membrane Lipids

Methods in Membrane Lipids
  • Author : Alex Dopico
  • Publisher : Springer Science & Business Media
  • Release : 30 August 2007
GET THIS BOOKMethods in Membrane Lipids

This book presents a compendium of methodologies for the study of membrane lipids, varying from traditional lab bench experimentation to computer simulation and theoretical models. The volume provides a comprehensive set of techniques for studying membrane lipids with a strong biophysical emphasis. It compares the various available techniques including the pros and cons as seen by the experts.

Thermodynamics and Biophysics of Biomedical Nanosystems

Thermodynamics and Biophysics of Biomedical Nanosystems
  • Author : Costas Demetzos,Natassa Pippa
  • Publisher : Springer
  • Release : 04 March 2019
GET THIS BOOKThermodynamics and Biophysics of Biomedical Nanosystems

This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell

Peptide-Lipid Interactions

Peptide-Lipid Interactions
  • Author : Sidney A. Simon,Thomas J. McIntosh
  • Publisher : Academic Press
  • Release : 13 November 2002
GET THIS BOOKPeptide-Lipid Interactions

This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion. Key Features * world-renowned experts * state-of-the-art experimental methods * monolayers, bilayers, biological membranes * theoretical aspects and computer simulations * rafts * synaptic transmission * membrane fusion * signal transduction

Liposomes, Lipid Bilayers and Model Membranes

Liposomes, Lipid Bilayers and Model Membranes
  • Author : Georg Pabst,Norbert Kučerka,Mu-Ping Nieh,John Katsaras
  • Publisher : CRC Press
  • Release : 04 March 2014
GET THIS BOOKLiposomes, Lipid Bilayers and Model Membranes

As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evolved from basic studies of the physicochemical properties of amphiphiles to their application in industry and medicine. Written by leading researchers in their fields, this book describes basic and applied research,

Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization

Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization
  • Author : Fatma N. Kök,Ahu Arslan Yildiz,Fatih Inci
  • Publisher : Springer
  • Release : 16 April 2019
GET THIS BOOKBiomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization

This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research