Drug Metabolism in Diseases

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

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  • Author : Wen Xie
  • Publisher : Academic Press
  • Pages : 294 pages
  • ISBN : 0128029633
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKDrug Metabolism in Diseases

Drug Metabolism in Diseases

Drug Metabolism in Diseases
  • Author : Wen Xie
  • Publisher : Academic Press
  • Release : 12 September 2016
GET THIS BOOKDrug Metabolism in Diseases

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and

Topics on Drug Metabolism

Topics on Drug Metabolism
  • Author : James Paxton
  • Publisher : BoD – Books on Demand
  • Release : 22 February 2012
GET THIS BOOKTopics on Drug Metabolism

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and

Principles of Pharmacology

Principles of Pharmacology
  • Author : David E. Golan
  • Publisher : Lippincott Williams & Wilkins
  • Release : 29 May 2022
GET THIS BOOKPrinciples of Pharmacology

This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system. Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes

Rational Therapeutics for Infants and Children

Rational Therapeutics for Infants and Children
  • Author : Institute of Medicine,Division of Health Sciences Policy,Roundtable on Research and Development of Drugs, Biologics, and Medical Devices,Jonathan R. Davis,Sarah Pitluck,Peter Bouxsein,Ronald W. Estabrook
  • Publisher : National Academies Press
  • Release : 07 April 2000
GET THIS BOOKRational Therapeutics for Infants and Children

The Institute of Medicine's (IOM's) Roundtable on Research and Development of Drugs, Biologics, and Medical Devices evolved from the Forum on Drug Development, which was established in 1986. Sponsor representatives and IOM determined the importance of maintaining a neutral setting for discussions regarding long-term and politically sensitive issues justified the need to revise and enhance past efforts. The new Roundtable is intended to be a mechanism by which a broad group of experts from the public* and private sectors can be

Inherited Metabolic Disease in Adults

Inherited Metabolic Disease in Adults
  • Author : Carla E. M. Hollak,Robin Lachmann
  • Publisher : Oxford University Press
  • Release : 29 May 2022
GET THIS BOOKInherited Metabolic Disease in Adults

As clinical management of inherited metabolic diseases (IMDs) has improved, more patients affected by these conditions are surviving into adulthood. This trend, coupled with the widespread recognition that IMDs can present differently and for the first time during adulthood, makes the need for a working knowledge of these diseases more important than ever. Inherited Metabolic Disease in Adults offers an authoritative clinical guide to the adult manifestations of these challenging and myriad conditions. These include both the classic pediatric-onset conditions

Surgical Procedures on the Cirrhotic Patient

Surgical Procedures on the Cirrhotic Patient
  • Author : Bijan Eghtesad,John Fung
  • Publisher : Springer
  • Release : 27 April 2017
GET THIS BOOKSurgical Procedures on the Cirrhotic Patient

This volume provides a concise yet comprehensive overview on surgical procedures performed on the cirrhotic patient. The text explains the underlying pathophysiologic alterations in liver disease and cirrhosis, provides assessment of disease severity and risk factors, and helps to predict potential outcomes based on the nature of the operation. Operations discussed in detail include bariatric surgery, colorectal surgery, hepatic surgery, kidney transplantation, gynecological procedures, neurosurgical procedures, and ophthalmic surgery. The book is also supplemented with instructive color illustrations and tables.

Cancer as a Metabolic Disease

Cancer as a Metabolic Disease
  • Author : Thomas Seyfried
  • Publisher : John Wiley & Sons
  • Release : 18 May 2012
GET THIS BOOKCancer as a Metabolic Disease

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position

Ketogenic Diet and Metabolic Therapies

Ketogenic Diet and Metabolic Therapies
  • Author : Susan A. Masino
  • Publisher : Oxford University Press
  • Release : 14 October 2016
GET THIS BOOKKetogenic Diet and Metabolic Therapies

Ketogenic diets have been used to successfully treat epilepsy and stop seizures for nearly a century. When more traditional therapies, such as pharmacology, reach their limitations for treatment, the metabolic approach surpasses, targeting the overall physiology and homeostatic functions of the patient. Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical

Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism
  • Author : Aparajita Dey
  • Publisher : Springer Science & Business Media
  • Release : 12 February 2013
GET THIS BOOKCytochrome P450 2E1: Its Role in Disease and Drug Metabolism

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic

Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases

Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases
  • Author : Ram B. Singh
  • Publisher : Academic Press
  • Release : 30 November 2021
GET THIS BOOKFunctional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases

Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases presents strategies for the prevention of non-communicable diseases and undernutrition through the use of functional foods and nutraceuticals. Research has shown that the use of certain functional foods and nutraceuticals, including spices, herbs, and millets, animal foods and plant foods can play a role in the treatment and prevention of various diseases and in health promotion. Finally, the book explores epigenetic modulation as a new method for the development of functional

Metabolism of Human Diseases

Metabolism of Human Diseases
  • Author : Eckhard Lammert,Martin Zeeb
  • Publisher : Springer Science & Business Media
  • Release : 02 June 2014
GET THIS BOOKMetabolism of Human Diseases

“Metabolism of Human Diseases” examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell

Xenosensor Regulation of Enzymes and Transporters in Drug Exposure and Disease

Xenosensor Regulation of Enzymes and Transporters in Drug Exposure and Disease
  • Author : Matthew David Merrell
  • Publisher : Unknown Publisher
  • Release : 29 May 2022
GET THIS BOOKXenosensor Regulation of Enzymes and Transporters in Drug Exposure and Disease

A large and varied array of xenobiotics (foreign chemicals) enters into our bodies every day. In order to prevent toxicity resulting from xenobiotic accumulation, the body has developed a complex and integrated network of enzymes and transporters to promote and control the metabolism and excretion of drugs and other compounds. Drug metabolizing enzymes are classified as oxidative (Phase I) or conjugative (Phase II), and generally result in increased hydrophilicity of their substrates. Drug transporters actively route xenobiotics into (Phase 0) or

Drug-Induced Liver Injury

Drug-Induced Liver Injury
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 13 July 2019
GET THIS BOOKDrug-Induced Liver Injury

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic