Dynemicin A Uncialamycin and Analogues

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds

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  • Author : Daniel Best
  • Publisher : Elsevier
  • Pages : 144 pages
  • ISBN : 0081010869
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKDynemicin A Uncialamycin and Analogues

Dynemicin A, Uncialamycin and Analogues

Dynemicin A, Uncialamycin and Analogues
  • Author : Daniel Best,Mickael Jean,Pierre Van De Weghe
  • Publisher : Elsevier
  • Release : 14 June 2016
GET THIS BOOKDynemicin A, Uncialamycin and Analogues

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details

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  • Publisher : John Wiley & Sons
  • Release : 31 March 2008
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  • Publisher : Springer Nature
  • Release : 01 January 2022
GET THIS BOOKMicrobes in Microbial Communities

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  • Publisher : John Wiley & Sons
  • Release : 05 February 2020
GET THIS BOOKBiphasic Chemistry and The Solvent Case

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  • Publisher : Elsevier
  • Release : 08 August 2018
GET THIS BOOKStudies in Natural Products Chemistry

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  • Publisher : Academic Press
  • Release : 29 May 2022
GET THIS BOOKNatural Product Biosynthesis by Microorganisms and Plants

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GET THIS BOOKBuilding a Practical Information Security Program

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  • Publisher : John Wiley & Sons
  • Release : 11 April 1996
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  • Release : 03 March 2014
GET THIS BOOKComputational Organic Chemistry

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  • Release : 11 November 2013
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