Electroporation Based Therapies for Cancer

Electroporation-Based Therapies for Cancer reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals. Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and chemo-resistant cancers, that do not respond well to current treatment regimen. An electrical-pulse-mediated, enhanced drug delivery technique known as electroporation is one way to effectively treat these patients. This technique is especially suitable for low- and middle-income countries, where lack of infrastructure and resources leads to cancer diagnoses at late stages. This quick, safe, effective, economical, out-patient-based technique is a boon to these patients for palliative and other care with enhanced quality of life. This book features discussions by interdisciplinary authors—including practicing oncological surgeons, medical professionals, and academic and other researchers—of the basics and clinical medical applications of electroporation. Provides novel and recent clinical applications of electrochemotherapy for various cancers, including melanomas, sarcomas, superficial extreme melanoma, chest wall breast carcinoma, and colorectal cancers Extensive study of a number of cell lines, including human breast cancer, lung cancer, cervical cancer, leukemia, and mouse breast cancer using both reversible and irreversible electroporation techniques In vitro study of delivery of various commonly prescribed/administered breast cancer chemo and hormone drugs, such as Doxorubicin, Paclitaxel, Bleomycin, and Tamoxifen

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  • Author : Raji Sundararajan
  • Publisher : Elsevier
  • Pages : 352 pages
  • ISBN : 1908818298
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKElectroporation Based Therapies for Cancer

Electroporation-Based Therapies for Cancer

Electroporation-Based Therapies for Cancer
  • Author : Raji Sundararajan
  • Publisher : Elsevier
  • Release : 28 August 2014
GET THIS BOOKElectroporation-Based Therapies for Cancer

Electroporation-Based Therapies for Cancer reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals. Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and

Electroporation-Based Therapies for Cancer: From Basics to Clinical Applications

Electroporation-Based Therapies for Cancer: From Basics to Clinical Applications
  • Author : Raji Sundararajan
  • Publisher : Woodhead Publishing
  • Release : 13 November 2017
GET THIS BOOKElectroporation-Based Therapies for Cancer: From Basics to Clinical Applications

"Electroporation-Based Therapies for Cancer" reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals. Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and

Electroporation-Based Therapies for Cancer

Electroporation-Based Therapies for Cancer
  • Author : Raji Sundararajan
  • Publisher : Woodhead Publishing
  • Release : 08 August 2014
GET THIS BOOKElectroporation-Based Therapies for Cancer

Electroporation-Based Therapies for Cancer reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals. Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and

Electroporation in Veterinary Oncology Practice

Electroporation in Veterinary Oncology Practice
  • Author : Joseph A. Impellizeri
  • Publisher : Springer Nature
  • Release : 20 November 2021
GET THIS BOOKElectroporation in Veterinary Oncology Practice

This is the first edited collection on veterinary applications of electroporation. Written by an international team of experts, this book presents worldwide emerging therapy options for cancer treatments in veterinary oncology practice. Electroporation offers a precision tool to target cancer cells without destroying surrounding tissue structures. The opening of tumor cell membranes facilitates local control of solid tumors either through the delivery of chemotherapeutics or by direct ablation of tissues using electric fields. In addition, transfer of gene-based products into

Irreversible Electroporation

Irreversible Electroporation
  • Author : Boris Rubinsky
  • Publisher : Springer Science & Business Media
  • Release : 25 November 2009
GET THIS BOOKIrreversible Electroporation

Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of

Principles and Technologies for Electromagnetic Energy Based Therapies

Principles and Technologies for Electromagnetic Energy Based Therapies
  • Author : Punit Prakash,Govindarajan Srimathveeravalli
  • Publisher : Academic Press
  • Release : 17 December 2021
GET THIS BOOKPrinciples and Technologies for Electromagnetic Energy Based Therapies

Principles and Technologies for Electromagnetic Energy Based Therapies covers the theoretical foundations of electromagnetic-energy based therapies, principles for design of practical devices and systems, techniques for in vitro and in vivo testing of devices, and clinical application examples of contemporary therapies employing non-ionizing electromagnetic energy. The book provides in-depth coverage of: pulsed electric fields, radiofrequency heating systems, tumor treating fields, and microwave heating technology. Devices and systems for electrical stimulation of neural and cardiac issue are covered as well. Lastly,

Bioprocess Engineering

Bioprocess Engineering
  • Author : Kim Gail Clarke
  • Publisher : Elsevier
  • Release : 31 October 2013
GET THIS BOOKBioprocess Engineering

Biotechnology is an expansive field incorporating expertise in both the life science and engineering disciplines. In biotechnology, the scientist is concerned with developing the most favourable biocatalysts, while the engineer is directed towards process performance, defining conditions and strategies that will maximize the production potential of the biocatalyst. Increasingly, the synergistic effect of the contributions of engineering and life sciences is recognised as key to the translation of new bioproducts from the laboratory bench to commercial bioprocess. Fundamental to the

Novel Drug and Gene Delivery

Novel Drug and Gene Delivery
  • Author : Christopher Gerard Collins
  • Publisher : Unknown Publisher
  • Release : 25 June 2022
GET THIS BOOKNovel Drug and Gene Delivery

Despite recent advances in the detection, diagnosis and treatment of cancer, this has not translated into increased survival, with the overall 5-year survival only modestly improved in the last 15 years. For patients with cancers unresponsive to conventional intervention, development of alternative therapies is crucial. Chemotherapy involves systemic delivery of cytotoxic drugs and has significant side effects. Electrochemotherapy is a new technique using electric pulses applied to tumour tissue rendering the tumour cell membranes permeable to otherwise impermeant or poorly permeant

Gene Therapy of Cancer

Gene Therapy of Cancer
  • Author : Edmund C. Lattime,Stanton L. Gerson
  • Publisher : Academic Press
  • Release : 28 August 2013
GET THIS BOOKGene Therapy of Cancer

Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide

Marine Enzymes for Biocatalysis

Marine Enzymes for Biocatalysis
  • Author : Antonio Trincone
  • Publisher : Elsevier
  • Release : 30 September 2013
GET THIS BOOKMarine Enzymes for Biocatalysis

Marine bioprospecting is a highly topical subject - in both applied and basic research - but, as yet, the marine ecosystem is a relatively unexplored source of natural bioactive substances with potential therapeutic activity. This book addresses the use of marine enzymes in biocatalysis through a series of chapters from leading scientists within academic and industrial fields. Biocatalytic processes can take advantage of the habitat-related properties of marine enzymes, such as salt tolerance, hyperthermostability, barophilicity, cold adaptivity, and so on,

Bioinformatics for Biomedical Science and Clinical Applications

Bioinformatics for Biomedical Science and Clinical Applications
  • Author : K-H Liang
  • Publisher : Elsevier
  • Release : 31 July 2013
GET THIS BOOKBioinformatics for Biomedical Science and Clinical Applications

Contemporary biomedical and clinical research is undergoing constant development thanks to the rapid advancement of various high throughput technologies at the DNA, RNA and protein levels. These technologies can generate vast amounts of raw data, making bioinformatics methodologies essential in their use for basic biomedical and clinical applications. Bioinformatics for biomedical science and clinical applications demonstrates what these cutting-edge technologies can do and examines how to design an appropriate study, including how to deal with data and address specific clinical

Practical Leadership for Biopharmaceutical Executives

Practical Leadership for Biopharmaceutical Executives
  • Author : Jane Y Chin
  • Publisher : Elsevier
  • Release : 05 May 2011
GET THIS BOOKPractical Leadership for Biopharmaceutical Executives

The biohealthcare executive in upper-middle management confronts leadership challenges unique to their industry: they manage highly specialized knowledge workers and innovators, compete at the speed of technology, work in a highly regulated environment where "free speech" often does not apply due to patient safety and privacy concerns, and increasingly are leading virtual teams who may be located in different parts of the world. Practical leadership for biopharmaceutical executives is a guide that strips away the theory and meets head-on the

Formulation tools for Pharmaceutical Development

Formulation tools for Pharmaceutical Development
  • Author : J E Aguilar
  • Publisher : Elsevier
  • Release : 30 September 2013
GET THIS BOOKFormulation tools for Pharmaceutical Development

A range of new and innovative tools used for preformulation and formulation of medicines help optimize pharmaceutical development projects. Such tools also assist with the performance evaluation of the pharmaceutical process, allowing any potential gaps to be identified. These tools can be applied in both basic research and industrial environment. Formulation tools for pharmaceutical development considers these key research and industrial tools. Nine chapters by leading contributors cover: Artificial neural networks technology to model, understand, and optimize drug formulations; ME_

Cancer Gene Therapy

Cancer Gene Therapy
  • Author : David T. Curiel,Joanne T. Douglas
  • Publisher : Springer Science & Business Media
  • Release : 03 November 2007
GET THIS BOOKCancer Gene Therapy

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail

Gene therapy

Gene therapy
  • Author : Surendra Nimesh
  • Publisher : Elsevier
  • Release : 31 October 2013
GET THIS BOOKGene therapy

Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors